NU4M_TRIRU
ID NU4M_TRIRU Reviewed; 494 AA.
AC Q36834; Q9T9N0;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 23-APR-2003, sequence version 2.
DT 25-MAY-2022, entry version 71.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 4;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 4;
GN Name=ND4; Synonyms=NADH4;
OS Trichophyton rubrum (Athlete's foot fungus) (Epidermophyton rubrum).
OG Mitochondrion.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Arthrodermataceae; Trichophyton.
OX NCBI_TaxID=5551;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=IP 1817.89;
RX PubMed=10022946; DOI=10.1007/s002940050429;
RA de Bievre C., Dujon B.;
RT "Organisation of the mitochondrial genome of Trichophyton rubrum III. DNA
RT sequence analysis of the NADH dehydrogenase subunits 1, 2, 3, 4, 5 and the
RT cytochrome b gene.";
RL Curr. Genet. 35:30-35(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 478-494.
RC STRAIN=IP 1817.89;
RX PubMed=8593686; DOI=10.1007/bf00518168;
RA de Bievre C., Dujon B.;
RT "Organisation of the mitochondrial genome of Trichophyton rubrum. DNA
RT sequence analysis of the ND4 gene, the ATPase subunit-6 gene, the ribosomal
RT RNA small-subunit gene, the ND6 gene, the COXIII gene, the ATPase subunit-8
RT gene and six tRNA genes that correspond respectively to the tyrosine,
RT lysine, glutamine, asparagine, isoleucine and tryptophan isoacceptors.";
RL Curr. Genet. 28:553-559(1995).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the complex I subunit 4 family. {ECO:0000305}.
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DR EMBL; Y18476; CAA77190.1; -; Genomic_DNA.
DR EMBL; X88896; CAA61354.1; -; Genomic_DNA.
DR PIR; T14246; T14246.
DR AlphaFoldDB; Q36834; -.
DR SMR; Q36834; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR InterPro; IPR010227; NADH_Q_OxRdtase_chainM/4.
DR InterPro; IPR003918; NADH_UbQ_OxRdtase.
DR InterPro; IPR001750; ND/Mrp_mem.
DR PANTHER; PTHR43507; PTHR43507; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR PRINTS; PR01437; NUOXDRDTASE4.
DR TIGRFAMs; TIGR01972; NDH_I_M; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; NAD; Respiratory chain;
KW Translocase; Transmembrane; Transmembrane helix; Transport; Ubiquinone.
FT CHAIN 1..494
FT /note="NADH-ubiquinone oxidoreductase chain 4"
FT /id="PRO_0000118001"
FT TRANSMEM 6..26
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 41..61
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..107
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 118..138
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 141..161
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 172..192
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 207..227
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 246..266
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 280..300
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 302..322
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 336..356
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 375..395
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 415..435
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 460..480
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 494 AA; 55768 MW; 1622F4BD8E4EA48F CRC64;
MFFQNIMIYL FSLLLIPLIV YFLLIYIRLR YSNNSNNQIK TIGLTTLIIN LILSMIIFIL
FDFSSKQFQL QLEEIYKISY FDLYLGIDGI SIYFLLLTTM IMPISLVANW NSIDSKNVLS
FVIIILLLET LLLAVFLVLD ILLFYIFFES ILPPLFLLIG LFGSSDKVRA SFYLFLYTLL
GSLFMLLSII TMSSIMGATA FDALSKANFS YITQLFLFYG IFISFAVKTP TIFLNTWLLK
AHVESPLAGS VILAGIVWKL RWYGIFRLII PLLPKASMDY TYIVYVIGVI TIFYTSFSTL
RTIAIKELIA YSSVSHAAVY LLSAFSNTIQ GIEGAIALGL AHGFVSSGLF ICVGGILYDR
SSTRLITYYR GMAQLMPIFC ILFLYITLGN CGSPLTLNFI GEFMSLYGIF ERISVLGVLA
STSIVFSAAY TIFMFNRIAF GGQFSSYFFN YVKDLSKREF ILLISLVVPA VFFGIYPAVI
LDGLHYSVSG LIYN
