NU5C_ANTAG
ID NU5C_ANTAG Reviewed; 732 AA.
AC Q859V1;
DT 10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 25-MAY-2022, entry version 64.
DE RecName: Full=NAD(P)H-quinone oxidoreductase subunit 5, chloroplastic;
DE EC=7.1.1.-;
DE AltName: Full=NAD(P)H dehydrogenase subunit 5;
DE AltName: Full=NADH-plastoquinone oxidoreductase subunit 5;
GN Name=ndhF;
OS Anthoceros angustus (Hornwort) (Anthoceros formosae).
OG Plastid; Chloroplast.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Anthocerotophyta;
OC Anthocerotopsida; Anthocerotidae; Anthocerotales; Anthocerotaceae;
OC Anthoceros.
OX NCBI_TaxID=48387;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND RNA EDITING.
RX PubMed=12527781; DOI=10.1093/nar/gkg155;
RA Kugita M., Kaneko A., Yamamoto Y., Takeya Y., Matsumoto T., Yoshinaga K.;
RT "The complete nucleotide sequence of the hornwort (Anthoceros formosae)
RT chloroplast genome: insight into the earliest land plants.";
RL Nucleic Acids Res. 31:716-721(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND RNA EDITING.
RC TISSUE=Thallus;
RX PubMed=12711687; DOI=10.1093/nar/gkg327;
RA Kugita M., Yamamoto Y., Fujikawa T., Matsumoto T., Yoshinaga K.;
RT "RNA editing in hornwort chloroplasts makes more than half the genes
RT functional.";
RL Nucleic Acids Res. 31:2417-2423(2003).
CC -!- FUNCTION: NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN
CC and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain
CC and possibly in a chloroplast respiratory chain. The immediate electron
CC acceptor for the enzyme in this species is believed to be
CC plastoquinone. Couples the redox reaction to proton translocation, and
CC thus conserves the redox energy in a proton gradient (By similarity).
CC {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a plastoquinone + (n+1) H(+)(in) + NADH = a plastoquinol + n
CC H(+)(out) + NAD(+); Xref=Rhea:RHEA:42608, Rhea:RHEA-COMP:9561,
CC Rhea:RHEA-COMP:9562, ChEBI:CHEBI:15378, ChEBI:CHEBI:17757,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:62192;
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a plastoquinone + (n+1) H(+)(in) + NADPH = a plastoquinol + n
CC H(+)(out) + NADP(+); Xref=Rhea:RHEA:42612, Rhea:RHEA-COMP:9561,
CC Rhea:RHEA-COMP:9562, ChEBI:CHEBI:15378, ChEBI:CHEBI:17757,
CC ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:62192;
CC -!- SUBUNIT: NDH is composed of at least 16 different subunits, 5 of which
CC are encoded in the nucleus. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Plastid, chloroplast thylakoid membrane
CC {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
CC -!- RNA EDITING: Modified_positions=27 {ECO:0000269|PubMed:12527781,
CC ECO:0000269|PubMed:12711687}, 46 {ECO:0000269|PubMed:12527781,
CC ECO:0000269|PubMed:12711687}, 70 {ECO:0000269|PubMed:12527781,
CC ECO:0000269|PubMed:12711687}, 75 {ECO:0000269|PubMed:12527781,
CC ECO:0000269|PubMed:12711687}, 83 {ECO:0000269|PubMed:12527781,
CC ECO:0000269|PubMed:12711687}, 91 {ECO:0000269|PubMed:12527781,
CC ECO:0000269|PubMed:12711687}, 125 {ECO:0000269|PubMed:12527781,
CC ECO:0000269|PubMed:12711687}, 128 {ECO:0000269|PubMed:12527781,
CC ECO:0000269|PubMed:12711687}, 183 {ECO:0000269|PubMed:12527781,
CC ECO:0000269|PubMed:12711687}, 194 {ECO:0000269|PubMed:12527781,
CC ECO:0000269|PubMed:12711687}, 209 {ECO:0000269|PubMed:12527781,
CC ECO:0000269|PubMed:12711687}, 223 {ECO:0000269|PubMed:12527781,
CC ECO:0000269|PubMed:12711687}, 259 {ECO:0000269|PubMed:12527781,
CC ECO:0000269|PubMed:12711687}, 282 {ECO:0000269|PubMed:12527781,
CC ECO:0000269|PubMed:12711687}, 291 {ECO:0000269|PubMed:12527781,
CC ECO:0000269|PubMed:12711687}, 303 {ECO:0000269|PubMed:12527781,
CC ECO:0000269|PubMed:12711687}, 311 {ECO:0000269|PubMed:12527781,
CC ECO:0000269|PubMed:12711687}, 322 {ECO:0000269|PubMed:12527781,
CC ECO:0000269|PubMed:12711687}, 334 {ECO:0000269|PubMed:12527781,
CC ECO:0000269|PubMed:12711687}, 344 {ECO:0000269|PubMed:12527781,
CC ECO:0000269|PubMed:12711687}, 346 {ECO:0000269|PubMed:12527781,
CC ECO:0000269|PubMed:12711687}, 355 {ECO:0000269|PubMed:12527781,
CC ECO:0000269|PubMed:12711687}, 366 {ECO:0000269|PubMed:12527781,
CC ECO:0000269|PubMed:12711687}, 374 {ECO:0000269|PubMed:12527781,
CC ECO:0000269|PubMed:12711687}, 379 {ECO:0000269|PubMed:12527781,
CC ECO:0000269|PubMed:12711687}, 399 {ECO:0000269|PubMed:12527781,
CC ECO:0000269|PubMed:12711687}, 403 {ECO:0000269|PubMed:12527781,
CC ECO:0000269|PubMed:12711687}, 410 {ECO:0000269|PubMed:12527781,
CC ECO:0000269|PubMed:12711687}, 427 {ECO:0000269|PubMed:12527781,
CC ECO:0000269|PubMed:12711687}, 445 {ECO:0000269|PubMed:12527781,
CC ECO:0000269|PubMed:12711687}, 463 {ECO:0000269|PubMed:12527781,
CC ECO:0000269|PubMed:12711687}, 492 {ECO:0000269|PubMed:12527781,
CC ECO:0000269|PubMed:12711687}, 550 {ECO:0000269|PubMed:12527781,
CC ECO:0000269|PubMed:12711687}, 634 {ECO:0000269|PubMed:12527781,
CC ECO:0000269|PubMed:12711687}; Note=The nonsense codons at positions 70
CC and 379 are modified to sense codons.;
CC -!- SIMILARITY: Belongs to the complex I subunit 5 family. {ECO:0000305}.
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DR EMBL; AB086179; BAC55396.1; -; Genomic_DNA.
DR EMBL; AB087481; BAC55496.1; -; mRNA.
DR RefSeq; NP_777459.1; NC_004543.1.
DR AlphaFoldDB; Q859V1; -.
DR SMR; Q859V1; -.
DR GeneID; 2553499; -.
DR GO; GO:0009535; C:chloroplast thylakoid membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:InterPro.
DR GO; GO:0048038; F:quinone binding; IEA:UniProtKB-KW.
DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR InterPro; IPR002128; NADH_UbQ_OxRdtase_chlpt_su5_C.
DR InterPro; IPR018393; NADHpl_OxRdtase_5_subgr.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR003945; NU5C-like.
DR InterPro; IPR001516; Proton_antipo_N.
DR PANTHER; PTHR42829; PTHR42829; 1.
DR Pfam; PF01010; Proton_antipo_C; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR Pfam; PF00662; Proton_antipo_N; 1.
DR TIGRFAMs; TIGR01974; NDH_I_L; 1.
PE 2: Evidence at transcript level;
KW Chloroplast; Membrane; NAD; NADP; Plastid; Plastoquinone; Quinone;
KW RNA editing; Thylakoid; Translocase; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..732
FT /note="NAD(P)H-quinone oxidoreductase subunit 5,
FT chloroplastic"
FT /id="PRO_0000118168"
FT TRANSMEM 9..29
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 39..59
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 89..109
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 125..145
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 147..167
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 184..204
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 215..235
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 258..278
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 291..311
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 327..347
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 353..373
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 395..415
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 420..440
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 544..564
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 604..624
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 712..732
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 732 AA; 82118 MW; FE9D03075351F40B CRC64;
MQLIYQCAWI VPLCPLISSI LIGLGLLFFE KSTKSIRRIC AISCILSLSV ATVICYNLSY
EQIIDNSIYQ YSWSWISNGD IVLEFGYLID PLTCIMLVLV TSVAIIVMIY SDGYMSHDEG
YVRFFVYLSL FTASMLGLVL SPNLIQIYIF WELVGMCSYL LIGFWFTRPS AANACQKAFI
TNRIGDFGLL LGILGFYWIT GSFEFENLFK GFKDLLINNE VSPFFAILCA SFLFLGPVAK
SAQFPLHVWL PDAMEGPTPI SALIHAATMV AAGIYLVARM FPLFETLPFV MSVISWTGAV
TALLGATLAF FQKDLKRGLA YSTMSQLGYM MLALGIGSYR AGLFHLITHA YSKALLFLGS
GSVIHSMEPI VGYRPDESQN MIFMGGLRKH MPITGTTFLL GTLSLCGIPP FACFWSKDEI
IADSWLYSPF IGWIALLTAG LTSFYMFRIY FLTFEGEFRA NSFKENTPVS SVSLWGEFRF
EEFGEKKADS VLQIVEKSSP KEFFRFVQSN RESSETQIGN YLSAYPSKEP IHFLYPKESD
YTMLIPLLIL SIPTLLIGFI GAPLPNGQLG SDLLSHWLNS FGNLSPERLS ENWLEFIEDA
ITSISIASFG IFSAFILYGP ASIFPRDLEK KIEPQLKGVW GFFINYMYNW SQYRGYIDQY
YNKIFVEGTR ILAYASSFFD RWIIDGIVNG TGISSFSGGE GMRYGEGGRV SSYLFGLVFG
MTILLAVILL II
