ID   NU5C_SYNY3              Reviewed;         681 AA.
AC   Q55429;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   25-MAY-2022, entry version 119.
DE   RecName: Full=NAD(P)H-quinone oxidoreductase chain 5;
DE            EC=7.1.1.-;
DE   AltName: Full=NAD(P)H dehydrogenase I, chain 5;
DE   AltName: Full=NDH-1, chain 5;
GN   Name=ndhF; OrderedLocusNames=slr0844;
OS   Synechocystis sp. (strain PCC 6803 / Kazusa).
OC   Bacteria; Cyanobacteria; Synechococcales; Merismopediaceae; Synechocystis;
OC   unclassified Synechocystis.
OX   NCBI_TaxID=1111708;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27184 / PCC 6803 / N-1;
RX   PubMed=8590279; DOI=10.1093/dnares/2.4.153;
RA   Kaneko T., Tanaka A., Sato S., Kotani H., Sazuka T., Miyajima N.,
RA   Sugiura M., Tabata S.;
RT   "Sequence analysis of the genome of the unicellular cyanobacterium
RT   Synechocystis sp. strain PCC6803. I. Sequence features in the 1 Mb region
RT   from map positions 64% to 92% of the genome.";
RL   DNA Res. 2:153-166(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PCC 6803 / Kazusa;
RX   PubMed=8905231; DOI=10.1093/dnares/3.3.109;
RA   Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y.,
RA   Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T.,
RA   Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.,
RA   Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT   "Sequence analysis of the genome of the unicellular cyanobacterium
RT   Synechocystis sp. strain PCC6803. II. Sequence determination of the entire
RT   genome and assignment of potential protein-coding regions.";
RL   DNA Res. 3:109-136(1996).
CC   -!- FUNCTION: NDH-1 shuttles electrons from NAD(P)H, via FMN and iron-
CC       sulfur (Fe-S) centers, to quinones in the respiratory chain. The
CC       immediate electron acceptor for the enzyme in this species is believed
CC       to be plastoquinone. Couples the redox reaction to proton translocation
CC       (for every two electrons transferred, four hydrogen ions are
CC       translocated across the cytoplasmic membrane), and thus conserves the
CC       redox energy in a proton gradient.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a plastoquinone + (n+1) H(+)(in) + NADH = a plastoquinol + n
CC         H(+)(out) + NAD(+); Xref=Rhea:RHEA:42608, Rhea:RHEA-COMP:9561,
CC         Rhea:RHEA-COMP:9562, ChEBI:CHEBI:15378, ChEBI:CHEBI:17757,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:62192;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a plastoquinone + (n+1) H(+)(in) + NADPH = a plastoquinol + n
CC         H(+)(out) + NADP(+); Xref=Rhea:RHEA:42612, Rhea:RHEA-COMP:9561,
CC         Rhea:RHEA-COMP:9562, ChEBI:CHEBI:15378, ChEBI:CHEBI:17757,
CC         ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:62192;
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the complex I subunit 5 family. {ECO:0000305}.
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DR   EMBL; BA000022; BAA10530.1; -; Genomic_DNA.
DR   PIR; S75795; S75795.
DR   AlphaFoldDB; Q55429; -.
DR   SMR; Q55429; -.
DR   IntAct; Q55429; 9.
DR   STRING; 1148.1001283; -.
DR   PaxDb; Q55429; -.
DR   EnsemblBacteria; BAA10530; BAA10530; BAA10530.
DR   KEGG; syn:slr0844; -.
DR   eggNOG; COG1009; Bacteria.
DR   InParanoid; Q55429; -.
DR   OMA; LIGFWQH; -.
DR   PhylomeDB; Q55429; -.
DR   Proteomes; UP000001425; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:InterPro.
DR   GO; GO:0048038; F:quinone binding; IEA:UniProtKB-KW.
DR   GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR   InterPro; IPR002128; NADH_UbQ_OxRdtase_chlpt_su5_C.
DR   InterPro; IPR018393; NADHpl_OxRdtase_5_subgr.
DR   InterPro; IPR001750; ND/Mrp_mem.
DR   InterPro; IPR003945; NU5C-like.
DR   InterPro; IPR001516; Proton_antipo_N.
DR   PANTHER; PTHR42829; PTHR42829; 1.
DR   Pfam; PF01010; Proton_antipo_C; 1.
DR   Pfam; PF00361; Proton_antipo_M; 1.
DR   Pfam; PF00662; Proton_antipo_N; 1.
DR   TIGRFAMs; TIGR01974; NDH_I_L; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; NAD; NADP; Plastoquinone; Quinone;
KW   Reference proteome; Translocase; Transmembrane; Transmembrane helix.
FT   CHAIN           1..681
FT                   /note="NAD(P)H-quinone oxidoreductase chain 5"
FT                   /id="PRO_0000118210"
FT   TRANSMEM        7..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        39..59
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        89..109
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        120..140
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        144..164
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        188..208
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        219..239
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        258..278
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        289..309
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        327..347
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        352..372
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        395..415
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        420..440
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        509..529
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        558..578
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        660..680
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   681 AA;  74400 MW;  D110C883B722FDAE CRC64;
     MELLYQLAWL IPVLPLFGAT VVGIGLISFN QATNKLRQIN AVFIISCLGA ALVMSGALLW
     DQIQGHASYA QMIEWASAGS FHLEMGYVID HLSALMLVIV TSVALLVMIY TDGYMAHDPG
     YVRFYAYLSL FASSMLGLVI SPNLVQVYIF WELVGMCSYL LIGFWYDRKA AADACQKAFV
     TNRVGDFGLL LGILGLYWAT GSFDFGTIGE RLEGLVSSGV LSGAIAAILA ILVFLGPVAK
     SAQFPLHVWL PDAMEGPTPI SALIHAATMV AAGVFLVARM YPVFEPIPVV MNTIAFTGCF
     TAFLGATIAL TQNDIKKGLA YSTISQLGYM VMAMGIGAYS AGLFHLMTHA YFKAMLFLCS
     GSVIHGMEGV VGHDPILAQD MRIMGGLRKY MPITATCFLI GTLAICGIPP FAGFWSKDEI
     LGLAFQANPL LWFVGWATAG MTAFYMFRMY FMTFEGGFRG NDQEAKDGVL QFYGLLPNFG
     PGAMNVKELD HEAGHDDHGH SSEPHESPLT MTFPLMALAV PSVLIGLLGR PWANQFEAFI
     HAPGEVVEHA AEFEWGEFYV MAGNSIGIAL IGITVASLMY WQHKFDPKVL AEKFPSLYQL
     SLNKWYFDDL YDKLFVQGSR RVARQIMEVD YKVIDGAVNL TGLVTLVSGE GLKYLENGRA
     QFYALIVFGA VLGFVIVFSL T