NU5H_NYCOV
ID NU5H_NYCOV Reviewed; 1849 AA.
AC Q5DUY0;
DT 24-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT 29-MAR-2005, sequence version 1.
DT 25-MAY-2022, entry version 46.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 5;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 5;
GN Name=nad5;
OS Nyctotherus ovalis.
OG Hydrogenosome.
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata; Armophorea;
OC Metopida; Metopidae; Nyctotherus.
OX NCBI_TaxID=70075;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15744302; DOI=10.1038/nature03343;
RA Boxma B., de Graaf R.M., van der Staay G.W.M., van Alen T.A., Ricard G.,
RA Gabaldon T., van Hoek A.H.A.M., Moon-van der Staay S.Y., Koopman W.J.H.,
RA van Hellemond J.J., Tielens A.G.M., Friedrich T., Veenhuis M., Huynen M.A.,
RA Hackstein J.H.P.;
RT "An anaerobic mitochondrion that produces hydrogen.";
RL Nature 434:74-79(2005).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Hydrogenosome membrane {ECO:0000305}; Multi-pass
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the complex I subunit 5 family. {ECO:0000305}.
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DR EMBL; AJ871267; CAI38858.1; -; Genomic_DNA.
DR AlphaFoldDB; Q5DUY0; -.
DR SMR; Q5DUY0; -.
DR GO; GO:0046859; C:hydrogenosomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR003945; NU5C-like.
DR PANTHER; PTHR42829; PTHR42829; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
PE 3: Inferred from homology;
KW Hydrogenosome; Membrane; NAD; Translocase; Transmembrane;
KW Transmembrane helix; Ubiquinone.
FT CHAIN 1..1849
FT /note="NADH-ubiquinone oxidoreductase chain 5"
FT /id="PRO_0000118163"
FT TRANSMEM 76..93
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..120
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 190..212
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 222..244
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 279..301
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 316..338
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 358..380
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 390..412
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 419..441
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 483..505
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 510..532
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 536..558
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 565..587
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 621..640
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 683..705
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 718..740
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 745..767
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 797..819
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 868..890
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 905..927
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 966..988
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1008..1030
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1073..1095
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1105..1127
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1172..1194
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1219..1241
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1248..1270
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1296..1318
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1330..1352
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1357..1379
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1418..1440
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1444..1466
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1478..1500
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1504..1526
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1533..1555
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1559..1581
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1602..1624
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1639..1661
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1719..1741
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1773..1795
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1802..1824
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1849 AA; 212911 MW; 7FB231B7AC7E687E CRC64;
MTKIVMLDYI PMLNNGGHRH PADIKPSMIN SLLDSMSIIL TSLCTFCEQL SLNEAIIVNL
GINTLDQLLM SQAGRYLLLY YCIYALELYT VCYSTLSLIL LYLIQLNYIL LTNIVGYLQY
SCSEIANLVY TYILLEGLLD VSELDALVVE TLLDYLWVPC DLIIRYYRAY WYFEGVYFNL
NIPYVQRSAY WLCVVIWNNI GWWTYQLMII GWYSLSCLCI RLVPTILAII NLILTYIDLI
IYLYDIYSNY SNMTWLGILY STINSIIRYD ISRIHAYQHL LTVIIPNYCL AIYNSGLILS
SLLLDIYHYQ IGLTILALQY LVAPLYISCS LLIYILCYIM TELLYSRSFY IDLLLRLLEI
IYLDILVNSL ISIIILILSV DVAYLIQLQV IILSQYINII SGYVAMPTTI LITWYLYNIA
VYIYYLVDYI ATISTLIIWL LERILWVYGI CANNIEPVVI DLPQLTLTSL DALLNQLLSE
WCLLDAIMNV VTSVILLITV SCLGVLRIIL FIAVYPVYCI GVLLLNTLLQ VVVGLISYII
GTFMNAIILI CDIYVYSIHR PFLPLIMYVY FVAAIILEPI IDIIHTIILA EHALFNTYCY
IIFDILQPLH LQAFEFYRDL IWLIADLILA YIDLIRSTLV EGIISFIKWR LEQDFQLVYD
ICEFYLDEVK PRIIRYWNIY SRWVRFLIYC AGNNINLLVL LYVQFKGYTL PMIILFDLTR
IQLYATIPVI ISSYIYQGIL QTMLIISYYN TLLVATLEFI QIWLTILSVS PEMLYTSTLG
ILLRSYYLLY EILLLEPTWV LFECLSTCVG LVELYLVTVE TTVSNILIID LILMEVLLED
IRQVATILTC ILDWYILETC LDMQYADILL LMSSGLQSTV LNTIFDLLSL LGLLDETSIR
FILELTVQVC TIPAALYSTI IYPYIVLVTR CLLYLPDVVQ LYLTIGEYLL RETLYQLLID
WASCKLYSYN LYLLELYNIY YFWLSLLEKY WTFTYHIYNY TTLVELSPDL LISLISYIID
ICILSLELLL EDIRWGSTIF VNLLDWYLLD TQLNIQYIDI LLITSYSVQN TLLTVVFYIL
NLCGILNEIS IQILFEITVQ ICTILATIYC TVVLPYILII LEILSYLPEI VQLYLDIGEH
LLLEILWQLL IDLLYYRAYD YILIAQLLCK VTYLLYIVLE QLLLVIIDLY IYIIGDLLII
GSCHVGNHII DILCSAENVY FLYFMIFIGY LLCGIFAFFY HGYLGTRGIF YLSEMIIMGI
LIFSIVTLYY NLKYHLALDI ILGELALSNE VIFTNIITFD ILSILGVLLV ATLTAIILTF
GVEYMLREAF AYNVLATLVL FSASIICFIV SYSFGLMIIF WEISGTLSLF LIDMYYARIR
TTQAVTRTFA LNRFGDLWMF TASIEIYSLC HNDALPTLFA LLPYAQFNLS ILGNLIFDFT
IPTVIVFSIF SAAACKCAQF LLFVWLPDAM EAPTPASALI HSSTLVVMGI FMILRFAPIL
HLSVYTLYIM SILGSLTVAY GAILATQTSD LKKAVAYSTI SQIGYLFTGC AFLAFRATLI
YLILHAICKA LLFVLVGYIV HMFGGTTSLR RMGGIYYIVP DIAIYMFILC MVLAGAPYTV
GFFAKELIVT TLTNTSSPVA TFIICCWIIS FACTPFYLYR ICVLPLFGRP RCSRRVFRNI
VSPQSTYNFI DSDSSLNSLL HKFTNLITRW SVQGRFTNLL HLLLLLIVLF CGEFLVFLVT
GLFGTSTTLF SDTAIDDSVY QLTDYYLLSY YRVRNIQLLI IVLFALVTLY ITAINNQLTF
NIIYLSVVLP ILAIIFICLG HYFLVDFTVY IYNISNSLIF ELLCDLAIC
