NU5M_AEDAE
ID NU5M_AEDAE Reviewed; 580 AA.
AC B0FWD3;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 26-FEB-2008, sequence version 1.
DT 25-MAY-2022, entry version 59.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 5;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 5;
GN Name=mt:ND5 {ECO:0000250|UniProtKB:P18932};
GN Synonyms=ND5 {ECO:0000312|EMBL:ABY51630.1};
OS Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OG Mitochondrion {ECO:0000312|EMBL:ABY51630.1}.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7159;
RN [1] {ECO:0000312|EMBL:ABY51630.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LVPib12 {ECO:0000312|EMBL:ABY51630.1};
RA Lobo N.F., Lovin D., DeBruyn B., Puiu D., Shumway M., Haas B., Nene V.,
RA Severson D.W.;
RT "The mitochondrial genome of the Yellow fever mosquito - Aedes aegypti.";
RL Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250, ECO:0000305}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305};
CC Multi-pass membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the complex I subunit 5 family. {ECO:0000255}.
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DR EMBL; EU352212; ABY51630.1; -; Genomic_DNA.
DR RefSeq; YP_001649169.1; NC_010241.1.
DR AlphaFoldDB; B0FWD3; -.
DR SMR; B0FWD3; -.
DR STRING; 7159.AAEL018678-PA; -.
DR VEuPathDB; VectorBase:AAEL018678; -.
DR eggNOG; KOG4668; Eukaryota.
DR HOGENOM; CLU_007100_6_0_1; -.
DR InParanoid; B0FWD3; -.
DR OrthoDB; 526738at2759; -.
DR Proteomes; UP000008820; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR InterPro; IPR010934; NADH_DH_su5_C.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR003945; NU5C-like.
DR InterPro; IPR001516; Proton_antipo_N.
DR PANTHER; PTHR42829; PTHR42829; 1.
DR Pfam; PF06455; NADH5_C; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR Pfam; PF00662; Proton_antipo_N; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Reference proteome; Respiratory chain; Translocase; Transmembrane;
KW Transmembrane helix; Transport; Ubiquinone.
FT CHAIN 1..580
FT /note="NADH-ubiquinone oxidoreductase chain 5"
FT /id="PRO_0000372688"
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 50..70
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 92..112
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 113..133
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 153..173
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 176..196
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 218..240
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 249..269
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 274..294
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 300..320
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 343..363
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 378..400
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 427..447
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 464..484
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 500..520
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 560..580
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 580 AA; 66522 MW; 2C9BF9E8CB50F1D8 CRC64;
MNYLVNYCKN SFYILIFISF TLFILSLKFL LMDLVYFIEW EIVSLHSMSI VMTFLFDWMS
LMFMSFVLLI SSLVIFYSDQ YMGEDYNVNR FILLVLMFVM SMMMLIISPN LISILLGWDG
LGLVSYCLVI YFQNVKSYNA GMLTALSNRI GDVALLLAIA WMLNYGSWNY IFYLDMMKNN
FEMMVIGGLV MLAAMTKSAQ IPFSSWLPAA MAAPTPVSAL VHSSTLVTAG VYLLIRFNIL
LDNSKLGQFL LLVSGLTMFM AGLGANFEFD LKKIIALSTL SQLGLMMSIL SIGYYKLAFF
HLLTHALFKA LLFMCAGVII HNTKNAQDIR FMGGLSMSMP LTCSCFNIAN LALCGMPFLA
GFYSKDLILE TVMLSYMNFF SFFLFFFSTG LTVCYSFRLV YYSMTGDFNS TTLNMLNDKG
WTMSFSIFFL MVMAIIGGSM LSWLMFFNPE MICLPYYLKN LTLMVCLLGG FTGYLISNVN
FFFINKSLVY YNFSFFSGSM WFMPLISTVG VVKWPLILGM YSYKMFDQGW SEYFGGQMLY
NQLKIYSLYV QEFQNNNLKI YLLSYMLWVI ILVSMMLFLN
