ID   NU5M_ALBCA              Reviewed;         545 AA.
AC   P48918;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 5;
DE            EC=7.1.1.2;
DE   AltName: Full=NADH dehydrogenase subunit 5;
GN   Name=ND5;
OS   Albinaria caerulea (Land snail).
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Heterobranchia; Euthyneura; Panpulmonata; Eupulmonata; Stylommatophora;
OC   Helicina; Clausilioidea; Clausiliidae; Alopiinae; Albinaria.
OX   NCBI_TaxID=42349;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7498775; DOI=10.1093/genetics/140.4.1353;
RA   Hatzoglou E., Rodakis G.C., Lecanidou R.;
RT   "Complete sequence and gene organization of the mitochondrial genome of the
RT   land snail Albinaria coerulea.";
RL   Genetics 140:1353-1366(1995).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) that is believed to belong to the
CC       minimal assembly required for catalysis. Complex I functions in the
CC       transfer of electrons from NADH to the respiratory chain. The immediate
CC       electron acceptor for the enzyme is believed to be ubiquinone (By
CC       similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 5 family. {ECO:0000305}.
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DR   EMBL; X83390; CAA58296.1; -; Genomic_DNA.
DR   PIR; S59143; S59143.
DR   RefSeq; NP_007329.1; NC_001761.1.
DR   AlphaFoldDB; P48918; -.
DR   SMR; P48918; -.
DR   GeneID; 808008; -.
DR   CTD; 4540; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR   GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR   InterPro; IPR001750; ND/Mrp_mem.
DR   InterPro; IPR003945; NU5C-like.
DR   InterPro; IPR001516; Proton_antipo_N.
DR   PANTHER; PTHR42829; PTHR42829; 1.
DR   Pfam; PF00361; Proton_antipo_M; 1.
DR   Pfam; PF00662; Proton_antipo_N; 1.
PE   3: Inferred from homology;
KW   Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW   Transport; Ubiquinone.
FT   CHAIN           1..545
FT                   /note="NADH-ubiquinone oxidoreductase chain 5"
FT                   /id="PRO_0000118051"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        47..67
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        79..99
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        100..120
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        141..161
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        162..178
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        195..217
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        230..250
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        263..283
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        285..305
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        322..342
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        360..380
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        406..426
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        442..462
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        525..545
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   545 AA;  61335 MW;  BE801FDEC7A18563 CRC64;
     MLLGVLCAIM GVIYMVLNMQ NSSYLLMFNL FSTQSVNFNL ALICDKVSTS FLVVVLLISS
     CVFLFANEYM SEDHYNIRFG WILISFVASM GILILSGSIF TLLLGWDGLG LTSFALIAYY
     DNYNASSSAF LTLMTNRLGD VLIIATFSVI LVTGLTVHFP PYTLVWLSSI LFTIASFTKS
     AQYPFSAWLP AAMAAPTPVS ALVHSSTLVT AGIYLMIRCF MVDGAPAEMY SLMGLVGSIT
     CLLGGSVALF EYDLKKVIAL STLSQLGVMM YSLSLNLPYL ALLHLYGHAM FKAMLFLGAG
     LILMMSYGTQ DLRLLGSLLY SSPIVISLLN ISMLCLMGFP FVSSFYSKHL ILEKMLDMNC
     NFFTSMMFML GTLLTGMYSI RLMKFLCWGN NNNKPSYCNM SWQSKMSMFP LAALAVLSGQ
     LMSYLDSSYM TFSWSTNQYN LILWGVLFLS IFFGIVMKFG NFYPTLMSSM MFLGPTSYNL
     LHYTKSLLIY MKRIDLSISE PNWVMSNLMY SSSWRVMSLF NWLTNYMLVT WFLLVWLMIM
     SILMW