NU5M_ALLMA
ID NU5M_ALLMA Reviewed; 641 AA.
AC P50365;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 25-MAY-2022, entry version 74.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 5;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 5;
GN Name=ND5; Synonyms=NAD5;
OS Allomyces macrogynus.
OG Mitochondrion.
OC Eukaryota; Fungi; Fungi incertae sedis; Blastocladiomycota;
OC Blastocladiomycota incertae sedis; Blastocladiomycetes; Blastocladiales;
OC Blastocladiaceae; Allomyces.
OX NCBI_TaxID=28583;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 46923 / Burma 3-35 (35OC);
RA Paquin B., Roewer I., Wang Z., Lang B.F.;
RT "A robust fungal phylogeny using the mitochondrially encoded nad5 protein
RT sequence.";
RL Can. J. Bot. 73:S180-S185(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 46923 / Burma 3-35 (35OC);
RX PubMed=8636971; DOI=10.1006/jmbi.1996.0056;
RA Paquin B., Lang B.F.;
RT "The mitochondrial DNA of Allomyces macrogynus: the complete genomic
RT sequence from an ancestral fungus.";
RL J. Mol. Biol. 255:688-701(1996).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the complex I subunit 5 family. {ECO:0000305}.
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DR EMBL; U17010; AAB05846.1; -; Genomic_DNA.
DR EMBL; U41288; AAC49228.1; -; Genomic_DNA.
DR PIR; S63645; S63645.
DR RefSeq; NP_043727.1; NC_001715.1.
DR AlphaFoldDB; P50365; -.
DR SMR; P50365; -.
DR GeneID; 801885; -.
DR VEuPathDB; FungiDB:AlmafMp08; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR InterPro; IPR010934; NADH_DH_su5_C.
DR InterPro; IPR018393; NADHpl_OxRdtase_5_subgr.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR003945; NU5C-like.
DR InterPro; IPR001516; Proton_antipo_N.
DR PANTHER; PTHR42829; PTHR42829; 1.
DR Pfam; PF06455; NADH5_C; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR Pfam; PF00662; Proton_antipo_N; 1.
DR TIGRFAMs; TIGR01974; NDH_I_L; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW Transport; Ubiquinone.
FT CHAIN 1..641
FT /note="NADH-ubiquinone oxidoreductase chain 5"
FT /id="PRO_0000118052"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 33..53
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 59..79
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 83..103
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 121..141
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 175..195
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 211..231
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 243..263
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 276..296
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 303..322
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 367..387
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 405..425
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 453..473
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 476..496
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 512..532
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 564..584
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 621..641
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 641 AA; 70675 MW; 9C64C376B72E7E61 CRC64;
MYLTIITLPL FAFLTVGVIG RKLGVRGSQI ITSLSIIISA ILSLYGFYEI VLLNNLGPIT
IYLSPWMNVI GAHADWAFYF DSISITMCVV VSSISSLVHL YSIGYMQGDP HIQRFFSYLS
LFTFFMLLLV TGNNYLLMFV GWEGIGVSSY LLINFWFTRI QANKASMQAM LVNRVGDLGF
VLGLFGIFWL FGSSDYDTVG IIAYKLDEQY ITIVTLFLLI AAIGKSAQLG LHTWLPSAME
GPTPVSALIH AATLVTAGVY LILRSSPLFE LAPTSLICVC VIGSLTAIFA ATTGLFQNDL
KRVIAYSTCS QLGYMVFALG LSQYEVAFFH LFNHAYFKAL LFLSAGSIIH ALHDEQDMRK
MGGLVNILPF TYTMILIGSL SLMALPFLTG YYSKDAILEV AYGQFLVTGT FTYWLGTITA
TITAFYSSKA LILGFFGTPN GSKKIYNTIH EAPLIMSIPL FLLSICSIFI GYITNKHLSV
IGIGSSGIIS GGVGTLRDHY LGFDIEFIST SFGVQFYPLF ASLLGISLAL IVLKDPKKMH
SIEKPEGLLN TVNITRWLSS KSYWFDNVYN TVLISGSLHF GGIFARDIDK GFLSLLGPQG
LQQLLITISR FFAIKIDTGF IPHYASIIII IPIFIILSIF I
