NU5M_ANOGA
ID NU5M_ANOGA Reviewed; 580 AA.
AC P34854; O20870; O20871; O20873; O20874; O20875; Q31664; Q31665;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1994, sequence version 1.
DT 25-MAY-2022, entry version 102.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 5;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 5;
GN Name=mt:ND5; Synonyms=ND5;
OS Anopheles gambiae (African malaria mosquito).
OG Mitochondrion.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7165;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=G3;
RX PubMed=9087549; DOI=10.1111/j.1365-2583.1993.tb00131.x;
RA Beard C.B., Hamm D.M., Collins F.H.;
RT "The mitochondrial genome of the mosquito Anopheles gambiae: DNA sequence,
RT genome organization, and comparisons with mitochondrial sequences of other
RT insects.";
RL Insect Mol. Biol. 2:103-124(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-265.
RC STRAIN=G3, GMMK6, and Muheza;
RX PubMed=8041714; DOI=10.1073/pnas.91.15.6885;
RA Besansky N.J., Powell J.R., Caccone A., Hamm D.M., Scott J.A.,
RA Collins F.H.;
RT "Molecular phylogeny of the Anopheles gambiae complex suggests genetic
RT introgression between principal malaria vectors.";
RL Proc. Natl. Acad. Sci. U.S.A. 91:6885-6888(1994).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 163-384, AND VARIANTS.
RX PubMed=9409838; DOI=10.1093/genetics/147.4.1817;
RA Besansky N.J., Lehmann T., Fahey G.T., Fontenille D., Braack L.E.O.,
RA Hawley W.A., Collins F.H.;
RT "Patterns of mitochondrial variation within and between African malaria
RT vectors, Anopheles gambiae and An. arabiensis, suggest extensive gene
RT flow.";
RL Genetics 147:1817-1828(1997).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the complex I subunit 5 family. {ECO:0000305}.
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DR EMBL; L20934; AAD12197.1; -; Genomic_DNA.
DR EMBL; U10126; AAB51635.1; -; Genomic_DNA.
DR EMBL; U10127; AAB51637.1; -; Genomic_DNA.
DR EMBL; U10128; AAB51639.1; -; Genomic_DNA.
DR EMBL; AF020967; AAB81769.1; -; Genomic_DNA.
DR EMBL; AF020968; AAB81770.1; -; Genomic_DNA.
DR EMBL; AF020970; AAB81772.1; -; Genomic_DNA.
DR EMBL; AF020971; AAB81773.1; -; Genomic_DNA.
DR EMBL; AF020973; AAB81775.1; -; Genomic_DNA.
DR EMBL; AF020980; AAB81782.1; -; Genomic_DNA.
DR EMBL; AF020988; AAB81790.1; -; Genomic_DNA.
DR EMBL; AF020989; AAB81791.1; -; Genomic_DNA.
DR EMBL; AF020991; AAB81793.1; -; Genomic_DNA.
DR EMBL; AF020992; AAB81794.1; -; Genomic_DNA.
DR EMBL; AF020993; AAB81795.1; -; Genomic_DNA.
DR EMBL; AF020998; AAB81800.1; -; Genomic_DNA.
DR EMBL; AF020999; AAB81801.1; -; Genomic_DNA.
DR EMBL; AF021002; AAB81804.1; -; Genomic_DNA.
DR EMBL; AF021003; AAB81805.1; -; Genomic_DNA.
DR EMBL; AF021011; AAB81813.1; -; Genomic_DNA.
DR EMBL; AF021012; AAB81814.1; -; Genomic_DNA.
DR EMBL; AF021013; AAB81815.1; -; Genomic_DNA.
DR EMBL; AF021014; AAB81816.1; -; Genomic_DNA.
DR EMBL; AF021015; AAB81817.1; -; Genomic_DNA.
DR EMBL; AF021016; AAB81818.1; -; Genomic_DNA.
DR EMBL; AF021017; AAB81819.1; -; Genomic_DNA.
DR EMBL; AF021018; AAB81820.1; -; Genomic_DNA.
DR EMBL; AF021019; AAB81821.1; -; Genomic_DNA.
DR EMBL; AF021020; AAB81822.1; -; Genomic_DNA.
DR EMBL; AF021021; AAB81823.1; -; Genomic_DNA.
DR EMBL; AF021022; AAB81824.1; -; Genomic_DNA.
DR EMBL; AF021023; AAB81825.1; -; Genomic_DNA.
DR PIR; T09808; T09808.
DR RefSeq; NP_008076.1; NC_002084.1.
DR AlphaFoldDB; P34854; -.
DR SMR; P34854; -.
DR STRING; 7165.AGAP028380-PA; -.
DR GeneID; 1267420; -.
DR KEGG; aga:ND5; -.
DR CTD; 4540; -.
DR VEuPathDB; VectorBase:AGAP028380; -.
DR eggNOG; KOG4668; Eukaryota.
DR HOGENOM; CLU_007100_6_0_1; -.
DR InParanoid; P34854; -.
DR OMA; GVGIMSF; -.
DR OrthoDB; 526738at2759; -.
DR Proteomes; UP000007062; Mitochondrion.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; IBA:GO_Central.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0003954; F:NADH dehydrogenase activity; IBA:GO_Central.
DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR GO; GO:0015990; P:electron transport coupled proton transport; IBA:GO_Central.
DR InterPro; IPR010934; NADH_DH_su5_C.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR003945; NU5C-like.
DR InterPro; IPR001516; Proton_antipo_N.
DR PANTHER; PTHR42829; PTHR42829; 1.
DR Pfam; PF06455; NADH5_C; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR Pfam; PF00662; Proton_antipo_N; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Reference proteome; Respiratory chain; Translocase; Transmembrane;
KW Transmembrane helix; Transport; Ubiquinone.
FT CHAIN 1..580
FT /note="NADH-ubiquinone oxidoreductase chain 5"
FT /id="PRO_0000118054"
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 50..70
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 92..112
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 113..133
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 153..173
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 183..203
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 215..235
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 244..264
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 274..293
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 298..320
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 343..363
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 367..387
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 427..447
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 463..483
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 496..516
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 560..580
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VARIANT 32
FT /note="M -> T (in strain: GMMK6)"
FT VARIANT 116
FT /note="L -> S (in strain: Muheza)"
FT VARIANT 181
FT /note="I -> V (in haplotype 25)"
FT VARIANT 190
FT /note="V -> F (in haplotype 38)"
FT VARIANT 239
FT /note="D -> N (in haplotype 39)"
FT VARIANT 377
FT /note="V -> M (in haplotype 24)"
FT VARIANT 378
FT /note="N -> K (in haplotype 24, haplotype 25 and haplotype
FT 27)"
SQ SEQUENCE 580 AA; 66293 MW; 28CF5D614BD62038 CRC64;
MNYLVNYCKI SFYFLMSISL SLFLISLKFL LMDLVYFIEW EILSLQSMSI VMTFLFDWMS
LMFMSFVLLI SSLVIFYSNQ YMEEDYNINR FILLVLMFVM SMMMLIISPN LISILLGWDG
LGLVSYCLVI YFQNVKSYNA GMLTALSNRI GDVALLLAIA WMLNYGSWNY IFYLDMMKNN
IEMMIIGGLV MLAAMTKSAQ IPFSSWLPAA MAAPTPVSAL VHSSTLVTAG VYLLIRFNDV
LMNWWMAQFL LLVSGLTMFM AGLGANFEFD LKKIIALSTL SQLGLMMSIL SMGFYKLAFF
HLLTHALFKA LLFMCAGSII HNMKNSQDIR MMGSLSMSMP LTCSCFNVAN LALCGMPFLA
GFYSKDLILE MVMLSYVNVF SFFLFFFSTG LTVCYSFRLV YYSMTGDFNS SSLHPLNDSG
WTMLFSICFL TVMAVIGGSM LSWLMFLNPA MICLPLEMKL LTLFVCIVGG LMGYLISDVK
LFFTNKALYF YNFTNFVGSM WFMPVISTLG VINYPLKLGL YSYKSFDQGW SEFFGGQMVY
FQLKNYSLYL QEFQSNSLKI YLLSYMLWFI ILLMLVVLVN
