NU5M_ANOQU
ID NU5M_ANOQU Reviewed; 576 AA.
AC P33510;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1994, sequence version 1.
DT 25-MAY-2022, entry version 77.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 5;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 5;
GN Name=ND5;
OS Anopheles quadrimaculatus (Common malaria mosquito).
OG Mitochondrion.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7166;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Orlando;
RX PubMed=2134168; DOI=10.1002/arch.940140104;
RA Cockburn A.F., Mitchell S.E., Seawright J.A.;
RT "Cloning of the mitochondrial genome of Anopheles quadrimaculatus.";
RL Arch. Insect Biochem. Physiol. 14:31-36(1990).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the complex I subunit 5 family. {ECO:0000305}.
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DR EMBL; L04272; AAA93547.1; -; Genomic_DNA.
DR AlphaFoldDB; P33510; -.
DR SMR; P33510; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR InterPro; IPR010934; NADH_DH_su5_C.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR003945; NU5C-like.
DR InterPro; IPR001516; Proton_antipo_N.
DR PANTHER; PTHR42829; PTHR42829; 1.
DR Pfam; PF06455; NADH5_C; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR Pfam; PF00662; Proton_antipo_N; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW Transport; Ubiquinone.
FT CHAIN 1..576
FT /note="NADH-ubiquinone oxidoreductase chain 5"
FT /id="PRO_0000118056"
FT TRANSMEM 6..26
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 46..66
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 88..108
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 109..129
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 149..169
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 179..199
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 211..231
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 240..260
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..289
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 294..316
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 339..359
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 363..383
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 423..443
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 459..479
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 492..512
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 556..576
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 576 AA; 65913 MW; A82B45D67F430F42 CRC64;
MNYCKISFYF LLSISLSLFL ISLKFLLKDL VYFIEWEAWV FKSMSIVMTF LFDWMSLMFM
SFVLLISSLV IFYSNQYMEE DYNINRFILL VLMFVMSMMM LIISPNLISI LLGWDGLGLV
SYCLVIYFQN VKSYNAGMLT ALSNRIGDVA LLLAIAWMLN YGSWNYIFYL EMMSKNTEMM
IIGGLVMLAA MTKSAQIPFS SWLPAAMAAP TPVSALVHSS TLVTAGLYLL IRFNILLTDW
WMGQFMLLIS GLTMFMAGLG ANFEFDLKKI IALSTLSQLG LMMSILSMGF YKLAFFHLLT
HALFKALLFM CAGSIIHNMK NSQDIRMMGS LSMSMPLTCS CFNVANLALC GMPFLAGFYS
KDLILEMVSL SYVNVFSFFL FFFSTGLTVC YSFRLVYYSM TGDFNSSVLH PLNDSGWTML
FSIFFLMIMA VIGGSMLSWL MFLNPSMICL PFDLKMLTLF VCILGGLIGY LLSNVSLFFT
NKALYFYNFT YFAGSMWFMP VVSTIGVINY PLKLGLYSYK SFDQGWSEFF GGQMIYNQLK
NYSLYLQEFQ MNSLKIYLLS YMLWFIVLLM LVVLVN