NU5M_ARBLI
ID NU5M_ARBLI Reviewed; 190 AA.
AC Q33753; Q33755;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 25-MAY-2022, entry version 71.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 5;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 5;
DE Flags: Fragment;
GN Name=ND5;
OS Arbacia lixula (Black urchin) (Echinus lixula).
OG Mitochondrion.
OC Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Echinoidea;
OC Euechinoidea; Echinacea; Arbacioida; Arbaciidae; Arbacia.
OX NCBI_TaxID=7640;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1681410; DOI=10.1093/oxfordjournals.molbev.a040661;
RA de Giorgi C., Lanave C., Musci M.D., Saccone C.;
RT "Mitochondrial DNA in the sea urchin Arbacia lixula: evolutionary
RT inferences from nucleotide sequence analysis.";
RL Mol. Biol. Evol. 8:515-529(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-80.
RX PubMed=1653758; DOI=10.1016/0378-1119(91)90281-f;
RA de Giorgi C., de Luca F., Saccone C.;
RT "Mitochondrial DNA in the sea urchin Arbacia lixula: nucleotide sequence
RT differences between two polymorphic molecules indicate asymmetry of
RT mutations.";
RL Gene 103:249-252(1991).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the complex I subunit 5 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; M74839; AAA98047.1; -; Genomic_DNA.
DR EMBL; M79454; AAA31639.2; -; Genomic_DNA.
DR AlphaFoldDB; Q33753; -.
DR SMR; Q33753; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR InterPro; IPR003945; NU5C-like.
DR PANTHER; PTHR42829; PTHR42829; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW Transport; Ubiquinone.
FT CHAIN 1..>190
FT /note="NADH-ubiquinone oxidoreductase chain 5"
FT /id="PRO_0000118060"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 68..88
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 94..114
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 118..138
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 146..166
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 167..187
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VARIANT 14
FT /note="L -> S"
FT NON_TER 190
SQ SEQUENCE 190 AA; 21157 MW; CEEAD130024F7C6F CRC64;
MVISPSTLLV SITLSIICLI VSILYTSKSF VAQRNFLTSG NIAFSGASLN ITSDGSAVYS
WTNGPFSINI LKFLAFLSLI NLFLFVGLEF QETNVTFSIW LSNTAANVSL SILFDHYFIV
FLTVALVVTW SIMNFSLLYG EDPNKNVFLL LTIFLLNMLI LTCSNSLFLL FLGWEGVGFL
SFLLIKMMNH
