NU5M_ASPNG
ID NU5M_ASPNG Reviewed; 656 AA.
AC Q6QU67;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 66.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 5;
DE EC=7.1.1.2;
GN Name=nad5;
OS Aspergillus niger.
OG Mitochondrion.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=5061;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=N909;
RX PubMed=15600010; DOI=10.1016/j.femsle.2004.10.025;
RA Juhasz A., Laday M., Gacser A., Kucsera J., Pfeiffer I., Kevei F.,
RA Hamari Z.;
RT "Mitochondrial DNA organisation of the mtDNA type 2b of Aspergillus
RT tubingensis compared to the Aspergillus niger mtDNA type 1a.";
RL FEMS Microbiol. Lett. 241:119-126(2004).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the complex I subunit 5 family. {ECO:0000305}.
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DR EMBL; AY525764; AAS66787.1; -; Genomic_DNA.
DR RefSeq; YP_337890.1; NC_007445.1.
DR AlphaFoldDB; Q6QU67; -.
DR SMR; Q6QU67; -.
DR GeneID; 3703575; -.
DR KEGG; ang:Asnifp15; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR InterPro; IPR010934; NADH_DH_su5_C.
DR InterPro; IPR018393; NADHpl_OxRdtase_5_subgr.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR003945; NU5C-like.
DR InterPro; IPR001516; Proton_antipo_N.
DR PANTHER; PTHR42829; PTHR42829; 1.
DR Pfam; PF06455; NADH5_C; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR Pfam; PF00662; Proton_antipo_N; 1.
DR TIGRFAMs; TIGR01974; NDH_I_L; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW Transport; Ubiquinone.
FT CHAIN 1..656
FT /note="NADH-ubiquinone oxidoreductase chain 5"
FT /id="PRO_0000118064"
FT TRANSMEM 4..21
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 28..50
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 81..103
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 112..129
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 133..155
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 176..198
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 208..230
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 243..262
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..294
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 301..319
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 329..351
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 364..386
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 409..431
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 452..471
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 514..536
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 603..625
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 629..651
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 656 AA; 73072 MW; 3DA662B67104AEF1 CRC64;
MYLTLIILPL LGSIVSGFFG RKVGVKGAHL ITCVSVITTT FLAILAFFEV GFNNIPVTIN
VARWVDVESL YVLWNFRFDS LTVSMFITVL IVSSLVHIYS ISYMSHDPHN QRFFSYLSLF
TFMMIILVTG NNYLIMFVGW EGVGVCSYLL VNFWFTRIAA NQSSLSALLT NREGDTLLTV
GMFAILWSFG NIDYSTVFAL APYYNENIIT IIGICLLIGA TAKSSQVGLH IWLPQAMEGP
TPVSALIHAA TMVTAGVYLL MRSSPLIEYS STVLVLCLWL GAITTVFSSL IGLFQQDIKK
VIAYSTMSQL GMMVIAVGLS SYNLALFHLV NHAFYKALLF LGAGSVIHAV ADNQDFRKYG
GLREFLPLTY SVMLIASLSL VAVPFMTGFY SKDFILESAY GQYYLSSTIV YFVATIGAMF
TTLYSAKVLY LTFLTNPNGP LVNYKHAHEG DLFMTIPLII LAIFSIFFGY LTKDIFIGLG
TGFFTDNSLF IHPSHEIMLD TEFAVPTFFK LLPFVFTVSL SLLSVLLSEF LPKLLINFKF
SRLGYNIFSF FNQRFYIELF YNKYIVEGVL KLGGQTSKNL NKGPVKLLGP YGLEKGGLAL
SNSLGNLSTG IVTTYALYIL IGLIFDISLL YFSYNDNNLL ILIIFTLFAL LNSNKK
