NU5M_BALPH
ID NU5M_BALPH Reviewed; 606 AA.
AC P24978;
DT 01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-1992, sequence version 1.
DT 25-MAY-2022, entry version 86.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 5;
DE EC=7.1.1.2 {ECO:0000250|UniProtKB:P03915};
DE AltName: Full=NADH dehydrogenase subunit 5;
GN Name=MT-ND5; Synonyms=MTND5, NADH5, ND5;
OS Balaenoptera physalus (Fin whale) (Balaena physalus).
OG Mitochondrion.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Mysticeti;
OC Balaenopteridae; Balaenoptera.
OX NCBI_TaxID=9770;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Isolate No. 27 / Anno 1987; TISSUE=Liver;
RX PubMed=1779436; DOI=10.1007/bf02102808;
RA Arnason U., Gullberg A., Widegren B.;
RT "The complete nucleotide sequence of the mitochondrial DNA of the fin
RT whale, Balaenoptera physalus.";
RL J. Mol. Evol. 33:556-568(1991).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC NADH through the respiratory chain, using ubiquinone as an electron
CC acceptor. Essential for the catalytic activity and assembly of complex
CC I. {ECO:0000250|UniProtKB:P03915}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC Evidence={ECO:0000250|UniProtKB:P03915};
CC -!- SUBUNIT: Core subunit of respiratory chain NADH dehydrogenase (Complex
CC I) which is composed of 45 different subunits.
CC {ECO:0000250|UniProtKB:P03920}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:P03920}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the complex I subunit 5 family. {ECO:0000305}.
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DR EMBL; X61145; CAA43449.1; -; Genomic_DNA.
DR PIR; C58851; C58851.
DR RefSeq; NP_006899.1; NC_001321.1.
DR AlphaFoldDB; P24978; -.
DR SMR; P24978; -.
DR GeneID; 807615; -.
DR CTD; 4540; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; ISS:UniProtKB.
DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; ISS:UniProtKB.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR InterPro; IPR010934; NADH_DH_su5_C.
DR InterPro; IPR018393; NADHpl_OxRdtase_5_subgr.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR003945; NU5C-like.
DR InterPro; IPR001516; Proton_antipo_N.
DR PANTHER; PTHR42829; PTHR42829; 1.
DR Pfam; PF06455; NADH5_C; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR Pfam; PF00662; Proton_antipo_N; 1.
DR TIGRFAMs; TIGR01974; NDH_I_L; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW Transport; Ubiquinone.
FT CHAIN 1..606
FT /note="NADH-ubiquinone oxidoreductase chain 5"
FT /id="PRO_0000118067"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 35..55
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..107
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 114..134
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 171..191
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 211..233
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 241..261
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 301..320
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 325..347
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 366..386
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 413..433
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 457..477
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 482..502
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 582..602
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 606 AA; 68043 MW; 5715CA2A5D892951 CRC64;
MNLFTSFTLL TLLILTTPIM MSHTGSHVNN KYQSYVKNIV FCAFITSLVP AMVYLHTNQE
TLISNWHWIT IQTLKLTLSF KMDYFSLMFM PVALFITWSI MEFSMWYMHS DPYINQFFKY
LLLFLITMLI LVTANNLFQL FIGWEGVGIM SFLLIGWWFG RTDANTAALQ AILYNRIGDI
GLLASMAWFL SNMNTWDLEQ IFMLNQNPLN FPLMGLVLAA AGKSAQFGLH PWLPSAMEGP
TPVSALLHSS TMVVAGIFLL VRFYPLMENN KLIQTVTLCL GAITTLFTAI CALTQNDIKK
IIAFSTSSQL GLMMVTIGLN QPYLAFLHIC THAFFKAMLF LCSGSIIHNL NNEQDIRKMG
GLFKALPFTT TALIIGCLAL TGMPFLTGFY SKDPIIEAAT SSYTNAWALL LTLIATSLTA
VYSTRIIFFA LLGQPRFPPS TTINENNPLL INPIKRLLVG SIFAGFILSN SIPPMTTPLM
TMPLHLKLTA LAMTTLGFII AFEINLDTQN LKHKHPSNSF KFSTLLGYFP TIMHRLPPHL
DLLMSQKLAT SLLDLTWLET ILPKTTALIQ LKASTLTSNQ QGLIKLYFLS FLITITLSMI
LFNYPE
