NU5M_BRALA
ID NU5M_BRALA Reviewed; 598 AA.
AC O79422;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 25-MAY-2022, entry version 76.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 5;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 5;
GN Name=ND5; Synonyms=NAD5, NADH5;
OS Branchiostoma lanceolatum (Common lancelet) (Amphioxus lanceolatum).
OG Mitochondrion.
OC Eukaryota; Metazoa; Chordata; Cephalochordata; Leptocardii; Amphioxiformes;
OC Branchiostomidae; Branchiostoma.
OX NCBI_TaxID=7740;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9628930; DOI=10.1093/nar/26.13.3279;
RA Spruyt N., Delarbre C., Gachelin G., Laudet V.;
RT "Complete sequence of the amphioxus (Branchiostoma lanceolatum)
RT mitochondrial genome: relations to vertebrates.";
RL Nucleic Acids Res. 26:3279-3285(1998).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the complex I subunit 5 family. {ECO:0000305}.
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DR EMBL; Y16474; CAA76257.1; -; Genomic_DNA.
DR PIR; D71391; D71391.
DR RefSeq; NP_007547.1; NC_001912.1.
DR AlphaFoldDB; O79422; -.
DR SMR; O79422; -.
DR GeneID; 808209; -.
DR CTD; 4540; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR InterPro; IPR010934; NADH_DH_su5_C.
DR InterPro; IPR018393; NADHpl_OxRdtase_5_subgr.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR003945; NU5C-like.
DR InterPro; IPR001516; Proton_antipo_N.
DR PANTHER; PTHR42829; PTHR42829; 1.
DR Pfam; PF06455; NADH5_C; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR Pfam; PF00662; Proton_antipo_N; 1.
DR TIGRFAMs; TIGR01974; NDH_I_L; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW Transport; Ubiquinone.
FT CHAIN 1..598
FT /note="NADH-ubiquinone oxidoreductase chain 5"
FT /id="PRO_0000118070"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 28..48
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 81..101
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 115..135
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 171..191
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 193..213
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 233..253
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 265..285
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 293..312
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 323..343
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 362..382
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 399..421
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 454..474
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 480..500
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 509..529
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 576..596
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 598 AA; 66098 MW; EDA986E0B8B1C565 CRC64;
MLELWGVLSL TSLGVMVIFL FSKIKSSFAE SVKYAGYMNA VLLSILLMSD ESEMLFLKWE
WVKLGGYSLM ISFRFDLYTC CFFVVGLYVT WNILMFSFYY MSTDPRIDLF CKYLGLFLIA
MLLLVSAESL FQLLIGWEGV GIMSYLLISW WYARSDANTA ALQAIFYNRV GDIGLLIMLM
WSLVTLGDWS FTGLYALDFV NTFFLLGVVL AAAGKSAQLG LHPWLPAAME GPTPVSSLLH
SSTMVVAGVF LLIRFSPIIL NHKEIQLMVF FLGTMTTLFS AICALAQNDM KKVVAFSTAS
QLGLMVTAVG AGAPQLAFLH ICMHAFFKAM LFMCSGSFIH GLQNEQDVRK MGGLYSAAPI
TSVCFFIGSA ALMGVPFLAG FFSKDPIIEI ININNLNSWA VGLVLIATSF TAAYSVRLLY
FSVGGVSRML VLQPMNEEYG NLIGPLQRLA YSSVIAGVVF IYFLSPNQIS CLSLPLSLKL
AAVFVTLVGG LIAWDVVNLL HREESVTNIP ELAFEAQVGF YPLIMHKLIP KVWLNMGEMY
QMQVMDRGWT ELALPQGLGG NYKIMADNVV NAQTSLIKMY IAVMVMMGGL ILGIMICL
