NU5M_CAEEL
ID NU5M_CAEEL Reviewed; 527 AA.
AC P24896;
DT 01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 2.
DT 25-MAY-2022, entry version 122.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 5;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 5;
GN Name=nduo-5 {ECO:0000312|WormBase:MTCE.35};
GN Synonyms=nd5 {ECO:0000312|WormBase:MTCE.35};
GN ORFNames=MTCE.35 {ECO:0000312|WormBase:MTCE.35};
OS Caenorhabditis elegans.
OG Mitochondrion.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=1551572; DOI=10.1093/genetics/130.3.471;
RA Okimoto R., Macfarlane J.L., Clary D.O., Wolstenholme D.R.;
RT "The mitochondrial genomes of two nematodes, Caenorhabditis elegans and
RT Ascaris suum.";
RL Genetics 130:471-498(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-120, AND VARIANT LEU-94.
RC STRAIN=AB1, AB2, Bristol N2, CB4852, CB4853, CB4854, CB4855, CB4856,
RC CB4857, CB4858, KR314, PB303, PB306, RW7000, and TR403;
RX PubMed=12644560; DOI=10.1093/molbev/msg044;
RA Denver D.R., Morris K., Thomas W.K.;
RT "Phylogenetics in Caenorhabditis elegans: an analysis of divergence and
RT outcrossing.";
RL Mol. Biol. Evol. 20:393-400(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-25.
RX PubMed=2235493; DOI=10.1093/nar/18.20.6113;
RA Okimoto R., Macfarlane J.L., Wolstenholme D.R.;
RT "Evidence for the frequent use of TTG as the translation initiation codon
RT of mitochondrial protein genes in the nematodes, Ascaris suum and
RT Caenorhabditis elegans.";
RL Nucleic Acids Res. 18:6113-6118(1990).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the complex I subunit 5 family. {ECO:0000305}.
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DR EMBL; X54252; CAA38162.1; -; Genomic_DNA.
DR EMBL; AY171208; AAO16356.1; -; Genomic_DNA.
DR EMBL; AY171209; AAO16358.1; -; Genomic_DNA.
DR EMBL; AY171210; AAO16360.1; -; Genomic_DNA.
DR EMBL; AY171211; AAO16362.1; -; Genomic_DNA.
DR EMBL; AY171212; AAO16364.1; -; Genomic_DNA.
DR EMBL; AY171213; AAO16366.1; -; Genomic_DNA.
DR EMBL; AY171214; AAO16368.1; -; Genomic_DNA.
DR EMBL; AY171215; AAO16370.1; -; Genomic_DNA.
DR EMBL; AY171216; AAO16372.1; -; Genomic_DNA.
DR EMBL; AY171217; AAO16374.1; -; Genomic_DNA.
DR EMBL; AY171218; AAO16376.1; -; Genomic_DNA.
DR EMBL; AY171219; AAO16378.1; -; Genomic_DNA.
DR EMBL; AY171220; AAO16380.1; -; Genomic_DNA.
DR EMBL; AY171221; AAO16382.1; -; Genomic_DNA.
DR EMBL; AY171222; AAO16384.1; -; Genomic_DNA.
DR PIR; S26037; S26037.
DR RefSeq; NP_006964.1; NC_001328.1.
DR AlphaFoldDB; P24896; -.
DR SMR; P24896; -.
DR STRING; 6239.MTCE.35; -.
DR EPD; P24896; -.
DR PaxDb; P24896; -.
DR EnsemblMetazoa; MTCE.35.1; MTCE.35.1; WBGene00010967.
DR GeneID; 2565703; -.
DR KEGG; cel:ND5; -.
DR CTD; 4540; -.
DR WormBase; MTCE.35; CE35353; WBGene00010967; nduo-5.
DR eggNOG; KOG4668; Eukaryota.
DR GeneTree; ENSGT00730000111303; -.
DR HOGENOM; CLU_517039_0_0_1; -.
DR InParanoid; P24896; -.
DR OrthoDB; 526738at2759; -.
DR PhylomeDB; P24896; -.
DR PRO; PR:P24896; -.
DR Proteomes; UP000001940; Mitochondrion.
DR Bgee; WBGene00010967; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; ISS:WormBase.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
DR GO; GO:0003954; F:NADH dehydrogenase activity; IBA:GO_Central.
DR GO; GO:0015990; P:electron transport coupled proton transport; IBA:GO_Central.
DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR003945; NU5C-like.
DR PANTHER; PTHR42829; PTHR42829; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Reference proteome; Respiratory chain; Translocase; Transmembrane;
KW Transmembrane helix; Transport; Ubiquinone.
FT CHAIN 1..527
FT /note="NADH-ubiquinone oxidoreductase chain 5"
FT /id="PRO_0000118072"
FT TRANSMEM 3..23
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 43..63
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 75..95
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 141..161
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 168..188
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..217
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 226..246
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 263..283
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 318..338
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 357..377
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 398..418
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 432..452
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 507..527
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VARIANT 94
FT /note="F -> L (in strain: CB4854)"
FT /evidence="ECO:0000269|PubMed:12644560"
SQ SEQUENCE 527 AA; 61156 MW; 8B804E4E0FF1EF72 CRC64;
MNISIFLIGF VFFMGGISVW LMPTFKLGIF FLEWDFLSLK FNFYFNSILF SFILFLVTFS
VLVFSTYYLN SELNFNYYYF VLLIFVGSMF SLNFSNSIFT MLLSWDLLGI SSFFLVLFYN
NWDSCSGAMN TALTNRLGDY FMFVFFGLSV FSGYYFLSFS MFSSYMSLLL LLTAFTKSAQ
FPFSSWLPKA MSAPTPVSSL VHSSTLVTAG LILLMNFNNL VMQKDFISFV LIIGLFTMFF
SSLASLVEED LKKVVALSTL SQMGFSMVTL GLGLSFISFI HLVSHALFKS CLFMQVGYII
HCSFGQQDGR NYSNNGNLPN FIQLQMLVTL FCLCGLIFSS GAVSKDFILE LFFSNNYMMF
FSLMFFVSVF LTFGYSFRLW KSFFLSFNKV MNHYSSTVFM NFLSLVLVIF SISFLWWMNF
NLLNIPSLFL YVDFFGPLVF LFMMIFLSFL ILKMLFKELM YKFLVDYLAK NSIYKMKNLK
FMDLFLNNIN SKGYTLFLSS GMFKNYYLKS LNFNSVVVLI FIFFMIC
