NU5M_CANAL
ID NU5M_CANAL Reviewed; 552 AA.
AC Q9B8C9;
DT 16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 2.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 5;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 5;
GN Name=NAD5; OrderedLocusNames=CM_00380W {ECO:0000312|CGD:CAL0000188422};
GN ORFNames=CaalfMp13;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OG Mitochondrion.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=11208783; DOI=10.1128/jb.183.3.865-872.2001;
RA Anderson J.B., Wickens C., Khan M., Cowen L.E., Federspiel N.A., Jones T.,
RA Kohn L.M.;
RT "Infrequent genetic exchange and recombination in the mitochondrial genome
RT of Candida albicans.";
RL J. Bacteriol. 183:865-872(2001).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the complex I subunit 5 family. {ECO:0000305}.
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DR EMBL; AF285261; AAG59597.2; -; Genomic_DNA.
DR RefSeq; NP_075040.2; NC_002653.1.
DR AlphaFoldDB; Q9B8C9; -.
DR SMR; Q9B8C9; -.
DR STRING; 237561.Q9B8C9; -.
DR PRIDE; Q9B8C9; -.
DR GeneID; 802564; -.
DR KEGG; cal:CaalfMp13; -.
DR CGD; CAL0000188422; NAD5.
DR VEuPathDB; FungiDB:CM_00380W; -.
DR InParanoid; Q9B8C9; -.
DR Proteomes; UP000000559; Mitochondrion.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; ISS:CGD.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; ISS:CGD.
DR GO; GO:0003954; F:NADH dehydrogenase activity; IBA:GO_Central.
DR GO; GO:0015990; P:electron transport coupled proton transport; IBA:GO_Central.
DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; ISS:CGD.
DR InterPro; IPR018393; NADHpl_OxRdtase_5_subgr.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR003945; NU5C-like.
DR InterPro; IPR001516; Proton_antipo_N.
DR PANTHER; PTHR42829; PTHR42829; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR Pfam; PF00662; Proton_antipo_N; 1.
DR TIGRFAMs; TIGR01974; NDH_I_L; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Reference proteome; Respiratory chain; Translocase; Transmembrane;
KW Transmembrane helix; Transport; Ubiquinone.
FT CHAIN 1..552
FT /note="NADH-ubiquinone oxidoreductase chain 5"
FT /id="PRO_0000356879"
FT TRANSMEM 11..31
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 36..56
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 68..88
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 89..109
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 121..141
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 152..172
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..216
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 229..249
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 256..274
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 287..307
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 322..342
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 365..386
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 406..426
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 453..473
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 532..552
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 552 AA; 61520 MW; F369B63E7BDD590E CRC64;
MQLLYYIYEE PVTIHLGTWI SLGDIVIPFG LSLDSLAMTV IVPVGIITLC VLAYAIEYMS
HDPNRNRFYI ILSIFAVFMT ILVVSDNYLM MFIGWEFVGV ISYLLISFWS TRITAMKSAL
SAILLNRMGD TFFVIALGLM INYYHAVDYD TIALVTPYMN TFLLNTLGLL LLLAATAKSA
QLGLHAWLLQ AMEGPTPVSA LLHAATMVCA GVYVLVRSYM ILEYTPTMLL IICWLGGLTT
LVSGLIAIVT NDIKRVIALS TMSQLSIMVL AIGISAYDLA IYHLYCHAFF KALLFMGAGS
VIHSFVAESQ DMRKYGGLIE YLPFSYTAIL IASLSLMAIP GLTGYYSKDI IIESLYGSYT
LSGYILYYIA VGSATLTSIY SLRVLYLTFM GVPNANKASY SHIHESLGMM IPMIVLVIYS
IFIGYSRDSV IGHYALSLPA NNGFIETEYT LPAYIKLLPL ILGLTLSAIL VYVYEYAYKI
NRSAVYDYLN NRIYYEQILN NIVIRNTLRL GGYMNAYIDQ GLLKVLGSTG VSRAVTYINV
IVIINILYLF FI
