NU5M_CANLF
ID NU5M_CANLF Reviewed; 606 AA.
AC Q9ZZ57; Q66QB1;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 3.
DT 25-MAY-2022, entry version 104.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 5;
DE EC=7.1.1.2 {ECO:0000250|UniProtKB:P03915};
DE AltName: Full=NADH dehydrogenase subunit 5;
GN Name=MT-ND5; Synonyms=MTND5, NADH5, ND5;
OS Canis lupus familiaris (Dog) (Canis familiaris).
OG Mitochondrion.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX NCBI_TaxID=9615;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Boxer {ECO:0000312|Proteomes:UP000002254};
RX PubMed=9878232; DOI=10.1006/mpev.1998.0513;
RA Kim K.S., Lee S.E., Jeong H.W., Ha J.H.;
RT "The complete nucleotide sequence of the domestic dog (Canis familiaris)
RT mitochondrial genome.";
RL Mol. Phylogenet. Evol. 10:210-220(1998).
RN [2]
RP SEQUENCE REVISION TO 117; 134; 201; 401 AND 405.
RA Kim K.S., Lee S.E., Jeong H.W., Jeong S.Y., Sohn H.S., Ha J.H.;
RL Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Beagle;
RA Zhu S., Xu Q., Chang H.;
RT "The complete mitochondrial DNA sequence of the Beagle dog (Canis
RT familiaris).";
RL Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC NADH through the respiratory chain, using ubiquinone as an electron
CC acceptor. Essential for the catalytic activity and assembly of complex
CC I. {ECO:0000250|UniProtKB:P03915}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC Evidence={ECO:0000250|UniProtKB:P03915};
CC -!- SUBUNIT: Core subunit of respiratory chain NADH dehydrogenase (Complex
CC I) which is composed of 45 different subunits.
CC {ECO:0000250|UniProtKB:P03920}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:P03920}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the complex I subunit 5 family. {ECO:0000305}.
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DR EMBL; U96639; AAD04773.2; -; Genomic_DNA.
DR EMBL; AY729880; AAU12157.1; -; Genomic_DNA.
DR PIR; T11503; T11503.
DR RefSeq; NP_008481.4; NC_002008.4.
DR AlphaFoldDB; Q9ZZ57; -.
DR SMR; Q9ZZ57; -.
DR STRING; 9612.ENSCAFP00000030319; -.
DR PaxDb; Q9ZZ57; -.
DR GeneID; 804484; -.
DR KEGG; cfa:804484; -.
DR CTD; 4540; -.
DR eggNOG; KOG4668; Eukaryota.
DR InParanoid; Q9ZZ57; -.
DR OrthoDB; 526738at2759; -.
DR Proteomes; UP000002254; Mitochondrion.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; IBA:GO_Central.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; ISS:UniProtKB.
DR GO; GO:0003954; F:NADH dehydrogenase activity; IBA:GO_Central.
DR GO; GO:0015990; P:electron transport coupled proton transport; IBA:GO_Central.
DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; ISS:UniProtKB.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR InterPro; IPR010934; NADH_DH_su5_C.
DR InterPro; IPR018393; NADHpl_OxRdtase_5_subgr.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR003945; NU5C-like.
DR InterPro; IPR001516; Proton_antipo_N.
DR PANTHER; PTHR42829; PTHR42829; 1.
DR Pfam; PF06455; NADH5_C; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR Pfam; PF00662; Proton_antipo_N; 1.
DR TIGRFAMs; TIGR01974; NDH_I_L; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Reference proteome; Respiratory chain; Translocase; Transmembrane;
KW Transmembrane helix; Transport; Ubiquinone.
FT CHAIN 1..606
FT /note="NADH-ubiquinone oxidoreductase chain 5"
FT /id="PRO_0000118073"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 43..63
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..107
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 117..137
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 171..191
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 201..221
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 241..261
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..293
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 310..330
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 365..385
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 409..429
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 457..477
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 488..508
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 582..602
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 63
FT /note="F -> I (in Ref. 1; AAD04773)"
FT /evidence="ECO:0000305"
FT CONFLICT 83
FT /note="N -> D (in Ref. 1; AAD04773)"
FT /evidence="ECO:0000305"
FT CONFLICT 300
FT /note="E -> K (in Ref. 1; AAD04773)"
FT /evidence="ECO:0000305"
FT CONFLICT 303
FT /note="S -> A (in Ref. 1; AAD04773)"
FT /evidence="ECO:0000305"
FT CONFLICT 335
FT /note="C -> F (in Ref. 1; AAD04773)"
FT /evidence="ECO:0000305"
FT CONFLICT 495
FT /note="I -> T (in Ref. 1; AAD04773)"
FT /evidence="ECO:0000305"
FT CONFLICT 508
FT /note="T -> S (in Ref. 1; AAD04773)"
FT /evidence="ECO:0000305"
FT CONFLICT 606
FT /note="E -> G (in Ref. 1; AAD04773)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 606 AA; 68465 MW; 51D20BE07765702A CRC64;
MNMFSSCMIT ALVILTLPII MSSTKLYKNK LYPYYVKTAT SYAFMISMIP TMMFIYSGQE
TIFSNWHWMT IQTMKLSMSF KLNYFSMIFV PVALFVTWSI MEFSMWYMHS DPYINRFFKY
LLLFLITMMV LVTANNMFQL FIGWEGVGIM SFLLIGWWYG RTDANTAALQ AVLYNRIGDV
GFIMTMAWFL LNLNTWDLQQ IFITTNDNFN LPLLGLLLAA TGKSAQFGLH PWLPSAMEGP
TPVSALLHSS TMVVAGVFLL IRFHPLMEHN QTIQTLTLCL GAITTLFTAI CALTQNDIKE
IVSFSTSSQL GLMMVTIGIN QPYLAFLHIC THAFCKAMLF MCSGSVIHSL NDEQDIRKMG
GLFKVLPFTT TSLIIGSLAL TGMPFLTGFY SKDLIIESAN TSNTNAWALL ITLVATSLTA
AYSTRIMFFA LLGQPRFSPM ILINENNPLL INSIKRLLIG SVFAGYIISH SITPTTIPQM
TMPHYLKMTA LAVTILGFIL ALELNLTTQG LKFNYPSNYF KFSSLLGYYP TIMHRLTPKT
SLTISQKSAS MLLDSIWLEN ILPKSISYFQ MKSSTLISNQ KGLIKLYFLS FMLTMILSLL
ILNYHE
