NU5M_CANLU
ID NU5M_CANLU Reviewed; 606 AA.
AC Q1HK80; Q1HKA6; Q1HKD2; Q1HKE5; Q3L6Y3;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 13-JUN-2006, sequence version 1.
DT 25-MAY-2022, entry version 57.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 5;
DE EC=7.1.1.2 {ECO:0000250|UniProtKB:P03915};
DE AltName: Full=NADH dehydrogenase subunit 5;
GN Name=MT-ND5; Synonyms=MTND5, NADH5, ND5;
OS Canis lupus (Gray wolf).
OG Mitochondrion.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX NCBI_TaxID=9612;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=15964215; DOI=10.1016/j.ympev.2005.04.025;
RA Delisle I., Strobeck C.;
RT "A phylogeny of the Caniformia (order Carnivora) based on 12 complete
RT protein-coding mitochondrial genes.";
RL Mol. Phylogenet. Evol. 37:192-201(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS ALA-77; PHE-77; SER-208;
RP LEU-209; ILE-371; VAL-375; HIS-442; MET-489 AND MET-495.
RX PubMed=16809672; DOI=10.1101/gr.5117706;
RA Bjornerfeldt S., Webster M.T., Vila C.;
RT "Relaxation of selective constraint on dog mitochondrial DNA following
RT domestication.";
RL Genome Res. 16:990-994(2006).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC NADH through the respiratory chain, using ubiquinone as an electron
CC acceptor. Essential for the catalytic activity and assembly of complex
CC I. {ECO:0000250|UniProtKB:P03915}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC Evidence={ECO:0000250|UniProtKB:P03915};
CC -!- SUBUNIT: Core subunit of respiratory chain NADH dehydrogenase (Complex
CC I) which is composed of 45 different subunits.
CC {ECO:0000250|UniProtKB:P03920}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:P03920}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the complex I subunit 5 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAU00451.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AY598505; AAU00451.1; ALT_INIT; Genomic_DNA.
DR EMBL; DQ480503; ABE48165.1; -; Genomic_DNA.
DR EMBL; DQ480504; ABE48178.1; -; Genomic_DNA.
DR EMBL; DQ480505; ABE48191.1; -; Genomic_DNA.
DR EMBL; DQ480506; ABE48204.1; -; Genomic_DNA.
DR EMBL; DQ480507; ABE48217.1; -; Genomic_DNA.
DR EMBL; DQ480508; ABE48230.1; -; Genomic_DNA.
DR RefSeq; YP_626738.1; NC_008092.1.
DR AlphaFoldDB; Q1HK80; -.
DR SMR; Q1HK80; -.
DR GeneID; 4097761; -.
DR CTD; 4540; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; ISS:UniProtKB.
DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; ISS:UniProtKB.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR InterPro; IPR010934; NADH_DH_su5_C.
DR InterPro; IPR018393; NADHpl_OxRdtase_5_subgr.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR003945; NU5C-like.
DR InterPro; IPR001516; Proton_antipo_N.
DR PANTHER; PTHR42829; PTHR42829; 1.
DR Pfam; PF06455; NADH5_C; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR Pfam; PF00662; Proton_antipo_N; 1.
DR TIGRFAMs; TIGR01974; NDH_I_L; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW Transport; Ubiquinone.
FT CHAIN 1..606
FT /note="NADH-ubiquinone oxidoreductase chain 5"
FT /id="PRO_0000269897"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 43..63
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..107
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 117..137
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 171..191
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 241..261
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..293
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 310..330
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 365..385
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 409..429
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 457..477
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 488..508
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 582..602
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VARIANT 77
FT /note="S -> A"
FT /evidence="ECO:0000269|PubMed:16809672"
FT VARIANT 77
FT /note="S -> F"
FT /evidence="ECO:0000269|PubMed:16809672"
FT VARIANT 208
FT /note="N -> S"
FT /evidence="ECO:0000269|PubMed:16809672"
FT VARIANT 209
FT /note="F -> L"
FT /evidence="ECO:0000269|PubMed:16809672"
FT VARIANT 371
FT /note="T -> I"
FT /evidence="ECO:0000269|PubMed:16809672"
FT VARIANT 375
FT /note="I -> V"
FT /evidence="ECO:0000269|PubMed:16809672"
FT VARIANT 442
FT /note="L -> H"
FT /evidence="ECO:0000269|PubMed:16809672"
FT VARIANT 489
FT /note="T -> M"
FT /evidence="ECO:0000269|PubMed:16809672"
FT VARIANT 495
FT /note="I -> M"
FT /evidence="ECO:0000269|PubMed:16809672"
SQ SEQUENCE 606 AA; 68402 MW; 7628DD4B5E5C4350 CRC64;
MNMFSSCMIT ALVILTLPII MSSTKLYKNK LYPYYVKTAT SYAFMISMIP TMMFIYSGQE
TIISNWHWMT IQTMKLSMSF KLDYFSMIFV PVALFVTWSI MEFSMWYMHS DPYINRFFKY
LLLFLITMMV LVTANNMFQL FIGWEGVGIM SFLLIGWWYG RTDANTAALQ AVLYNRIGDV
GFIMTMAWFL LNLNTWDLQQ IFITTNDNFN LPLLGLLLAA TGKSAQFGLH PWLPSAMEGP
TPVSALLHSS TMVVAGVFLL IRFHPLMEHN QTIQTLTLCL GAITTLFTAI CALTQNDIKK
IVAFSTSSQL GLMMVTIGIN QPYLAFLHIC THAFFKAMLF MCSGSIIHSL NDEQDIRKMG
GLFKVLPFTT TSLIIGSLAL TGMPFLTGFY SKDLIIESAN TSNTNAWALL ITLVATSLTA
AYSTRIMFFA LLGQPRFSPM ILINENNPLL INSIKRLLIG SVFAGYIISH SITPTTIPQM
TMPHYLKMTA LAVTILGFIL ALELNLTTQG LKFNYPSNYF KFSSLLGYYP TIMHRLTPKT
SLTISQKSAS MLLDSIWLEN ILPKSISYFQ MKSSTLISNQ KGLIKLYFLS FMLTMILSLL
ILNYHG
