NU5M_CANPA
ID NU5M_CANPA Reviewed; 555 AA.
AC P48919;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2004, sequence version 2.
DT 25-MAY-2022, entry version 82.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 5;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 5;
GN Name=ND5; Synonyms=NAD5;
OS Candida parapsilosis (Yeast).
OG Mitochondrion.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=5480;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=SR23 / CBS 7157;
RX PubMed=7521869; DOI=10.1128/jb.176.18.5622-5630.1994;
RA Nosek J., Fukuhara H.;
RT "NADH dehydrogenase subunit genes in the mitochondrial DNA of yeasts.";
RL J. Bacteriol. 176:5622-5630(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SR23 / CBS 7157;
RX PubMed=15449175; DOI=10.1007/s00438-004-1046-0;
RA Nosek J., Novotna M., Hlavatovicova Z., Ussery D.W., Fajkus J., Tomaska L.;
RT "Complete DNA sequence of the linear mitochondrial genome of the pathogenic
RT yeast Candida parapsilosis.";
RL Mol. Genet. Genomics 272:173-180(2004).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the complex I subunit 5 family. {ECO:0000305}.
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DR EMBL; X74411; CAE54609.1; -; Genomic_DNA.
DR RefSeq; NP_943647.1; NC_005253.2.
DR AlphaFoldDB; P48919; -.
DR SMR; P48919; -.
DR GeneID; 2657779; -.
DR CGD; CAL0000145005; CapafMp15.
DR VEuPathDB; FungiDB:CapafMp15; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR InterPro; IPR010934; NADH_DH_su5_C.
DR InterPro; IPR018393; NADHpl_OxRdtase_5_subgr.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR003945; NU5C-like.
DR InterPro; IPR001516; Proton_antipo_N.
DR PANTHER; PTHR42829; PTHR42829; 1.
DR Pfam; PF06455; NADH5_C; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR Pfam; PF00662; Proton_antipo_N; 1.
DR TIGRFAMs; TIGR01974; NDH_I_L; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW Transport; Ubiquinone.
FT CHAIN 1..555
FT /note="NADH-ubiquinone oxidoreductase chain 5"
FT /id="PRO_0000118074"
FT TRANSMEM 37..57
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 69..89
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 90..110
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 133..153
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 155..175
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..217
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 230..250
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 257..275
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 287..307
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 323..343
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 366..388
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 406..426
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 454..474
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 494..516
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 534..554
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 555 AA; 62518 MW; 60423C2CEE556ACD CRC64;
MFQYLYYIWE EPISISLGNW LNIGDIIIPY GLSLDSLAMT VMIPVGIVTL CVLLYAIEYM
SHDPNRNTFY IILSVFAIFM TILVVSDNYI MMFIGWEFVG VISYLLISFW STRIAAMKAA
LSAILLNRMG DTFFMLALGI FLSYFHAVDF DTLSLAAPYT NTLILNILSL LLLLAATAKS
AQLGLHAWLL QAMEGPTPVS ALLHAATMVC AGVYVLVRSY FILEYAPSLL IGICWLGGVT
TLVSGLIAIV TNDIKKVIAL STMSQLSIMV LAIGISSYDL AIYHLYCHAF FKALLFMGAG
SVIHSYISET QDMRKYGGLV NYLPFSYTAI LIASLSLMAI PGLTGYYSKD IIIESLYGTY
TFSGYILYYM AVGSATLTSL YSIRVLYLTF YNNPNSNKAT YQHIHENIRM LIPMIILVIY
SIFIGFNRDN VIGHYAMSLP ANNSFIETEF TLPWYIKLLP LILGLSLSLL LVYIYEYAYK
VRPSSIYNYF NNKIYYDQLL NNVIIRKTLI FGGYLNTYID NGLLKVLGST GISRALTYIN
IGIFLNLLYL FFFYR
