NU5M_CARAU
ID NU5M_CARAU Reviewed; 607 AA.
AC O78688;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 25-MAY-2022, entry version 76.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 5;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 5;
GN Name=MT-ND5; Synonyms=MTND5, NADH5, ND5;
OS Carassius auratus (Goldfish).
OG Mitochondrion.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Cyprininae; Carassius.
OX NCBI_TaxID=7957;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=AZ3 / Langsdorfi; TISSUE=Oocyte;
RA Murakami M., Yamashita Y., Fujitani H.;
RT "The complete sequence of mitochondrial genome from a gynogenetic triploid
RT 'ginbuna' (Carassius auratus langsdorfi).";
RL Zool. Sci. 15:335-337(1998).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the complex I subunit 5 family. {ECO:0000305}.
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DR EMBL; AB006953; BAA31248.1; -; Genomic_DNA.
DR RefSeq; NP_008598.1; NC_002079.1.
DR AlphaFoldDB; O78688; -.
DR SMR; O78688; -.
DR Ensembl; ENSCART00000000033; ENSCARP00000000012; ENSCARG00000000033.
DR GeneID; 808419; -.
DR CTD; 4540; -.
DR Proteomes; UP000515129; Mitochondrion MT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR InterPro; IPR010934; NADH_DH_su5_C.
DR InterPro; IPR018393; NADHpl_OxRdtase_5_subgr.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR003945; NU5C-like.
DR InterPro; IPR001516; Proton_antipo_N.
DR PANTHER; PTHR42829; PTHR42829; 1.
DR Pfam; PF06455; NADH5_C; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR Pfam; PF00662; Proton_antipo_N; 1.
DR TIGRFAMs; TIGR01974; NDH_I_L; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Reference proteome; Respiratory chain; Translocase; Transmembrane;
KW Transmembrane helix; Transport; Ubiquinone.
FT CHAIN 1..607
FT /note="NADH-ubiquinone oxidoreductase chain 5"
FT /id="PRO_0000118075"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 44..64
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 88..108
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 118..138
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 139..159
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 172..192
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 243..263
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 274..294
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 303..323
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 326..346
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 372..392
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 406..426
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 450..470
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 490..510
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 587..607
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 607 AA; 67313 MW; F791EB3DB060C199 CRC64;
MTLIMHSSLL LIFFILMYPL LTTLNPNQQG SNMAGMTKTA VSSAFFISLL PLMIFLNLKT
EGIITNWQWM NTQTFDVNIS FKFDHYSLIF VPIALYVTWS ILEFALWYMH SDPYIDRFFK
YLLTFLVAMI ILVTANNMFQ LFIGWEGVGI MSFLLIGWWH GRADANTAAL QAVIYNRVGD
IGLIMTMAWF AMNLNSWEIQ QIFVLSKNFD MTIPLMGLAL AATGKSAQFG LHPWLPSAME
GPTPVSALLH SSTMVVAGIF LLIRLHPLME NNQLALTTCL CLGALTSLFT ATCALTQNDI
KKIVAFSTSS QLGLMMVTIG LNQPQLAFLH ICTHAFFKAM LFLCSGSIIH SLNDEQDIRK
MGGLFSIMPA TSTYFTIGSL ALTGTPFLAG FFSKDAIIEA LNTSHLNAWA LTLTLIATSF
TAVYSFRLVY FVVMGTPRFL ALSPINENNP LVINSIKRLA WGSIVAGLII TQNFLPMKTP
IMTMPTTLKM AALLVTIAGL LVAMELANMT SKQMKITPII PLHHFSNMLG FFPTIVHRLL
PKLKLTLGQS AATQLDKTWL EAMGPKGLAL TQMTMAKVTN DVSRGMIKTY LTIFLLTLIL
AILPVLL
