NU5M_CHICK
ID NU5M_CHICK Reviewed; 605 AA.
AC P18940;
DT 01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1990, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 5;
DE EC=7.1.1.2 {ECO:0000250|UniProtKB:P03915};
DE AltName: Full=NADH dehydrogenase subunit 5;
GN Name=MT-ND5; Synonyms=MTND5, NADH5, ND5;
OS Gallus gallus (Chicken).
OG Mitochondrion.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Red jungle fowl {ECO:0000312|Proteomes:UP000000539};
RX PubMed=2329578; DOI=10.1016/0022-2836(90)90225-b;
RA Desjardins P., Morais R.;
RT "Sequence and gene organization of the chicken mitochondrial genome. A
RT novel gene order in higher vertebrates.";
RL J. Mol. Biol. 212:599-634(1990).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC NADH through the respiratory chain, using ubiquinone as an electron
CC acceptor. Essential for the catalytic activity and assembly of complex
CC I. {ECO:0000250|UniProtKB:P03915}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC Evidence={ECO:0000250|UniProtKB:P03915};
CC -!- SUBUNIT: Core subunit of respiratory chain NADH dehydrogenase (Complex
CC I) which is composed of 45 different subunits.
CC {ECO:0000250|UniProtKB:P03920}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:P03920}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the complex I subunit 5 family. {ECO:0000305}.
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DR EMBL; X52392; CAA36635.1; -; Genomic_DNA.
DR PIR; S10197; S10197.
DR RefSeq; NP_006925.1; NC_001323.1.
DR AlphaFoldDB; P18940; -.
DR SMR; P18940; -.
DR STRING; 9031.ENSGALP00000034622; -.
DR PaxDb; P18940; -.
DR Ensembl; ENSGALT00000047001; ENSGALP00000050219; ENSGALG00000029500.
DR VEuPathDB; HostDB:geneid_63549495; -.
DR eggNOG; KOG4668; Eukaryota.
DR GeneTree; ENSGT00730000111303; -.
DR HOGENOM; CLU_007100_6_0_1; -.
DR InParanoid; P18940; -.
DR OMA; GVGIMSF; -.
DR OrthoDB; 526738at2759; -.
DR PhylomeDB; P18940; -.
DR TreeFam; TF342974; -.
DR Reactome; R-GGA-611105; Respiratory electron transport.
DR Reactome; R-GGA-6799198; Complex I biogenesis.
DR PRO; PR:P18940; -.
DR Proteomes; UP000000539; Mitochondrion.
DR Bgee; ENSGALG00000029500; Expressed in cerebellum and 12 other tissues.
DR ExpressionAtlas; P18940; baseline and differential.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; IBA:GO_Central.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; ISS:UniProtKB.
DR GO; GO:0003954; F:NADH dehydrogenase activity; IBA:GO_Central.
DR GO; GO:0015990; P:electron transport coupled proton transport; IBA:GO_Central.
DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; ISS:UniProtKB.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR InterPro; IPR010934; NADH_DH_su5_C.
DR InterPro; IPR018393; NADHpl_OxRdtase_5_subgr.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR003945; NU5C-like.
DR InterPro; IPR001516; Proton_antipo_N.
DR PANTHER; PTHR42829; PTHR42829; 1.
DR Pfam; PF06455; NADH5_C; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR Pfam; PF00662; Proton_antipo_N; 1.
DR TIGRFAMs; TIGR01974; NDH_I_L; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Reference proteome; Respiratory chain; Translocase; Transmembrane;
KW Transmembrane helix; Transport; Ubiquinone.
FT CHAIN 1..605
FT /note="NADH-ubiquinone oxidoreductase chain 5"
FT /id="PRO_0000118078"
FT TRANSMEM 10..30
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 44..64
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 88..108
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 114..134
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 139..159
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 178..198
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 213..233
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 241..261
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..293
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 301..319
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 332..352
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 370..390
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 404..424
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 448..468
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 489..509
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 583..603
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 605 AA; 66374 MW; BC150F8693131E0F CRC64;
METPLLLNTL TTLTLLTLLT PIILPPLLNL KNSPMSITKT IKTAFLISLI PTTIFIHSGA
ESIATHWEWQ FIPNFKIPIS LKMDMYSMMF FPIALFVTWS ILEFATWYMA SEPFITKFFT
YLLTFLIAML TLTIANNMFL LFVGWEGVGI MSFLLIGWWQ GRAEANTAAL QAMIYNRIGD
IGLILSMAWL ASSLNTWEIQ QITHPNQTPT LPLLGLILAA TGKSAQFGLH PWLPAAMEGP
TPVSALLHSS TMVVAGIFLL IRTHPFLSSN KTALTTCLCL GALSTLFAAT CALTQNDIKK
IIAFSTSSQL GLMMVTIGLD LPQLAFLHIS THAFFKAMLF LCSGLIIHSL NGEQDIRKMG
CLQKTLPMTT SCLTIGNLAL MGTPFLAGFY SKDLIIENLN TSYINTWALS LTLLATSFTA
TYSLRMTLLV QTGHTRTPSN HPINENTPPA ILPIMRLALG SIMAGLLISS LILPPKTPPM
TMPTITKTAA IIVTTLGIIL ALELSSLSYS LTPPKHNPLM NFSSSLGYFN PLTHRISPSI
LLHTGQKIAS HLIDMAWYKK MGPEGLANLH LTMTKISTTL HTGLIKSYLG SFALTILTTI
LLIQK
