ID   NU5M_CHIMO              Reviewed;         612 AA.
AC   Q94RJ2;
DT   27-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 5;
DE            EC=7.1.1.2;
DE   AltName: Full=NADH dehydrogenase subunit 5;
GN   Name=MT-ND5; Synonyms=MTND5, NADH5, ND5;
OS   Chimaera monstrosa (Rabbit fish).
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC   Holocephali; Chimaeriformes; Chimaeridae; Chimaera.
OX   NCBI_TaxID=7871;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Arnason U., Gullberg A., Janke A.;
RT   "Molecular phylogenetics of gnathostomous (jawed) fishes: old bones, new
RT   cartilage.";
RL   Zool. Scr. 30:249-255(2001).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) that is believed to belong to the
CC       minimal assembly required for catalysis. Complex I functions in the
CC       transfer of electrons from NADH to the respiratory chain. The immediate
CC       electron acceptor for the enzyme is believed to be ubiquinone (By
CC       similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 5 family. {ECO:0000305}.
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DR   EMBL; AJ310140; CAC84209.1; -; Genomic_DNA.
DR   RefSeq; NP_395450.1; NC_003136.1.
DR   AlphaFoldDB; Q94RJ2; -.
DR   SMR; Q94RJ2; -.
DR   GeneID; 803910; -.
DR   CTD; 4540; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR   GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR   InterPro; IPR010934; NADH_DH_su5_C.
DR   InterPro; IPR018393; NADHpl_OxRdtase_5_subgr.
DR   InterPro; IPR001750; ND/Mrp_mem.
DR   InterPro; IPR003945; NU5C-like.
DR   InterPro; IPR001516; Proton_antipo_N.
DR   PANTHER; PTHR42829; PTHR42829; 1.
DR   Pfam; PF06455; NADH5_C; 1.
DR   Pfam; PF00361; Proton_antipo_M; 1.
DR   Pfam; PF00662; Proton_antipo_N; 1.
DR   TIGRFAMs; TIGR01974; NDH_I_L; 1.
PE   3: Inferred from homology;
KW   Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW   Transport; Ubiquinone.
FT   CHAIN           1..612
FT                   /note="NADH-ubiquinone oxidoreductase chain 5"
FT                   /id="PRO_0000118079"
FT   TRANSMEM        4..24
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        45..65
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        88..108
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        118..138
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        141..161
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        172..192
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        202..222
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        243..263
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        275..295
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        327..349
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        372..392
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        406..426
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        459..476
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        490..510
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        585..605
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   612 AA;  69193 MW;  6A9E6B3F2C2F6FDB CRC64;
     MNYIFNLSYF MILLLLLYPL ILPLCQKFFD KNLEKHTKWA IKLSFFISLI PLTLFIDQGI
     QTIIMNISWI HLPLFNINLS FKFDMYSIMF TSVALYVTWS ILDFTSWYMY SDPNINRFFK
     YLLLFLITMI LLVTANNMFQ LFIGWEGVGI MSFLLIGWWY GRADANTAAL QAVIYNRIGD
     IGLILSMIWL ATNLNSWEMN QFMVLSKNLN LTIPLLGLIL AATGKSAQFG LHPWLPSAME
     GPTPVSALLH SSTMVVAGIF LLVRLNPLFQ NNKEILTVCL CLGALTTLFT AICALTQNDI
     KKIIAFSTSS QLGLMMVTIG LNQPYLAFLH VCTHAFFKAM LFLCSGSIIH SLNNEQDIRK
     MGGLNNILPF TSSCMVLGSL ALTGMPFLAG FFSKDAIIES LNTSYLNAWA LILTLIATSF
     TAIYSLRLIS FTMMGHPRFL PVSPINENHK LLKNPLKRLA YGSILAGFII TSNIPHNKSM
     IMTMPPLMKL MALLVTIVGL LLALELANLT TKQFKILPNM KMHNFSNMLG YYPPIIHRFL
     PKMSLKWGQT IATHTMDLNW YEKTGPKMTE LNQKIIKIIH SPQKGVIKTY LTLSLLSIIT
     LLVFFNLSLN HS