NU5M_CHOCR
ID NU5M_CHOCR Reviewed; 666 AA.
AC P48920;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 1.
DT 25-MAY-2022, entry version 78.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 5;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 5;
GN Name=ND5; Synonyms=NAD5;
OS Chondrus crispus (Carrageen Irish moss) (Polymorpha crispa).
OG Mitochondrion.
OC Eukaryota; Rhodophyta; Florideophyceae; Rhodymeniophycidae; Gigartinales;
OC Gigartinaceae; Chondrus.
OX NCBI_TaxID=2769;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC TISSUE=Apices;
RX PubMed=7616569; DOI=10.1006/jmbi.1995.0392;
RA Leblanc C., Boyen C., Richard O., Bonnard G., Grienenberger J.-M.,
RA Kloareg B.;
RT "Complete sequence of the mitochondrial DNA of the rhodophyte Chondrus
RT crispus (Gigartinales). Gene content and genome organization.";
RL J. Mol. Biol. 250:484-495(1995).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the complex I subunit 5 family. {ECO:0000305}.
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DR EMBL; Z47547; CAA87625.1; -; Genomic_DNA.
DR PIR; S59109; S59109.
DR RefSeq; NP_062497.1; NC_001677.2.
DR AlphaFoldDB; P48920; -.
DR SMR; P48920; -.
DR GeneID; 809387; -.
DR KEGG; ccp:ChcroMp18; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR InterPro; IPR010934; NADH_DH_su5_C.
DR InterPro; IPR018393; NADHpl_OxRdtase_5_subgr.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR003945; NU5C-like.
DR InterPro; IPR001516; Proton_antipo_N.
DR PANTHER; PTHR42829; PTHR42829; 1.
DR Pfam; PF06455; NADH5_C; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR Pfam; PF00662; Proton_antipo_N; 1.
DR TIGRFAMs; TIGR01974; NDH_I_L; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW Transport; Ubiquinone.
FT CHAIN 1..666
FT /note="NADH-ubiquinone oxidoreductase chain 5"
FT /id="PRO_0000118081"
FT TRANSMEM 3..23
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 31..51
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 59..78
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 82..101
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 119..139
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 168..190
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 211..231
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 251..271
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 283..303
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 311..333
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 337..357
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 375..395
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 421..441
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 467..487
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 524..544
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 572..594
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 629..649
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 666 AA; 75629 MW; 37E86F2C24B9D360 CRC64;
MYLLILFLPL LGSLISGFGG RWLGCRGTNT FSTLCVVVSS LFSLLAFFEI GLTNTTCTIF
LVSWIKSGAF YVSWGFLFDS LTVTMLVVIT LVSSLVHIYS IKYMENDPHQ PRFMSYLEIF
TFFMLILVTA DNLIQMFLGW EGVGLASYLL INFWYTRLAA NQSAIKALIV NRVGDFGLSL
GIFLIFWVFN SVDYSVIFSL VPLFDNQFLT FLGFKLHVLT LISLFLFIGA IGKSAQLGLH
TWLPDAMEGP TPVSALIHAA TMVTAGVFLM IRFSPLLEFS PTILFILITF GSLTAFFAAV
TGVFQHDLKR VIAYSTCSQL GYMIFSCGMS CYDVSLFHLA NHAFFKALLF LSAGSVIHAV
SNEQDMRRMG SLLKFMPLTY SVMLIGTLAL IGFPFLTGFY SKDFILELTQ ISSYSNLQMS
YISFACWLGT MSVFFTSFYS FRLIYLTFLN NTNLAKSSLN LVHESSLLMI FPLIILSIGS
IFAGYLIRDL FVGSGSDFWG AAIFILPKHS TFIEAEELPI VVKWLPFILS LLGIFFASFV
QIFLKTFYFK SNLQNLLSFF TFLINKKWYW DVLYNRLIVL PILNFGYSIS FKILDRGFIE
LSGPYGFTKF VSFWSQILIK LQTGQITHYL FFMIFTFCSF SIILVYSYIN LTFNLLLLFF
TLFFFI
