NU5M_CRYNH
ID NU5M_CRYNH Reviewed; 662 AA.
AC Q85T01; J9VXW2;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 25-MAY-2022, entry version 79.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 5;
DE EC=7.1.1.2;
GN Name=ND5; ORFNames=CNAG_09006;
OS Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 /
OS CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii).
OG Mitochondrion.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=235443;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H99 / ATCC 208821 / CBS 10515 / FGSC 9487;
RA Allen A., Truesdell G., Li X., Dietrich F.S.;
RT "Sequence of the mitochondrial genome of Cryptococcus neoformans serotype A
RT strain H99.";
RL Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H99 / ATCC 208821 / CBS 10515 / FGSC 9487;
RX PubMed=24743168; DOI=10.1371/journal.pgen.1004261;
RA Janbon G., Ormerod K.L., Paulet D., Byrnes E.J. III, Yadav V.,
RA Chatterjee G., Mullapudi N., Hon C.-C., Billmyre R.B., Brunel F.,
RA Bahn Y.-S., Chen W., Chen Y., Chow E.W.L., Coppee J.-Y., Floyd-Averette A.,
RA Gaillardin C., Gerik K.J., Goldberg J., Gonzalez-Hilarion S., Gujja S.,
RA Hamlin J.L., Hsueh Y.-P., Ianiri G., Jones S., Kodira C.D., Kozubowski L.,
RA Lam W., Marra M., Mesner L.D., Mieczkowski P.A., Moyrand F., Nielsen K.,
RA Proux C., Rossignol T., Schein J.E., Sun S., Wollschlaeger C., Wood I.A.,
RA Zeng Q., Neuveglise C., Newlon C.S., Perfect J.R., Lodge J.K., Idnurm A.,
RA Stajich J.E., Kronstad J.W., Sanyal K., Heitman J., Fraser J.A.,
RA Cuomo C.A., Dietrich F.S.;
RT "Analysis of the genome and transcriptome of Cryptococcus neoformans var.
RT grubii reveals complex RNA expression and microevolution leading to
RT virulence attenuation.";
RL PLoS Genet. 10:E1004261-E1004261(2014).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the complex I subunit 5 family. {ECO:0000305}.
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DR EMBL; AY101381; AAN37584.1; -; Genomic_DNA.
DR EMBL; CP003834; AFR99108.1; -; Genomic_DNA.
DR RefSeq; NP_705908.1; NC_004336.1.
DR RefSeq; YP_006883713.1; NC_018792.1.
DR AlphaFoldDB; Q85T01; -.
DR SMR; Q85T01; -.
DR EnsemblFungi; AFR99108; AFR99108; CNAG_09006.
DR GeneID; 13824773; -.
DR GeneID; 805396; -.
DR VEuPathDB; FungiDB:CNAG_09006; -.
DR HOGENOM; CLU_007100_6_0_1; -.
DR PRO; PR:Q85T01; -.
DR Proteomes; UP000010091; Mitochondrion.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR InterPro; IPR010934; NADH_DH_su5_C.
DR InterPro; IPR018393; NADHpl_OxRdtase_5_subgr.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR003945; NU5C-like.
DR InterPro; IPR001516; Proton_antipo_N.
DR PANTHER; PTHR42829; PTHR42829; 1.
DR Pfam; PF06455; NADH5_C; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR Pfam; PF00662; Proton_antipo_N; 1.
DR TIGRFAMs; TIGR01974; NDH_I_L; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW Transport; Ubiquinone.
FT CHAIN 1..662
FT /note="NADH-ubiquinone oxidoreductase chain 5"
FT /id="PRO_0000118083"
FT TRANSMEM 40..62
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 77..99
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 112..129
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 133..155
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 168..190
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 200..222
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 243..262
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..294
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 301..320
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 325..347
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 360..382
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 408..430
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 450..472
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 510..529
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 609..631
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 636..658
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 662 AA; 71896 MW; E8B1778533104C29 CRC64;
MYLAILALPM FGSAVAGLRG RTIGVTGAHI ITTGCLMTSA ALSIVAFYEV GLSGSPVSIV
IGSWIDSEFM LVQWGFLFDS LTVSMLLPVL IVSSLVHLYS ISYMAGDPHN QRFFSYLSMF
TFFMLVLVAG DNYFIMFVGW EGIGISSYLL INFWYTRMQA NKAGMKALTV NRVGDMFLSV
GFFAIFWVFG NVDYASVFSV APYINETAIT IIGLLLLVGA MAKSANIPLH TWLPDAMEGP
TPVSALIHAA TLVTAGVYLM LRSSPIIEYG PTVLVVITWV GALTAFFAAT TGLLQNDLKR
VIAYSTCSQM GYLFMAVGLS QYNVALFHLV NHAFFKALLF LAAGAVIHGM ADQQDLRRLG
GLVNFLPFTY TAILIGSLSL MALPFMTGFY SKDLILEVAL GQYEVSGTIA YWLGTISAVF
TAFYSFRLVS LTFFTTPNAP KGDYLHAHEA PMIIVIPLVI LSIMSIVFGY IAKDMFVGVG
TDFLSTALFQ HPDHITLIEA EFGLPLLMKL LPAIGSLFGA GLALYLYHVV PSITISLTNG
PIGYGVYSFL NAKWYWDALY NGLIIESGLR IGLVISKVID RGIIELTGPY GLSTVLTGAG
RSVATYDTGV ITSYALYIML GLVSLIFLVF APTNMVFNEY GLSLILVYLS ALVLLPSSTR
TS
