NU5M_CYPCA
ID NU5M_CYPCA Reviewed; 607 AA.
AC P24979;
DT 01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-1992, sequence version 1.
DT 25-MAY-2022, entry version 85.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 5;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 5;
GN Name=MT-ND5; Synonyms=MTND5, NADH5, ND5;
OS Cyprinus carpio (Common carp).
OG Mitochondrion.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Cyprininae; Cyprinus.
OX NCBI_TaxID=7962;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8169959; DOI=10.1007/bf00166161;
RA Chang Y.S., Huang F.L., Lo T.B.;
RT "The complete nucleotide sequence and gene organization of carp (Cyprinus
RT carpio) mitochondrial genome.";
RL J. Mol. Evol. 38:138-155(1994).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the complex I subunit 5 family. {ECO:0000305}.
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DR EMBL; X61010; CAA43337.1; -; Genomic_DNA.
DR PIR; S36006; S36006.
DR RefSeq; NP_007092.1; NC_001606.1.
DR AlphaFoldDB; P24979; -.
DR SMR; P24979; -.
DR Ensembl; ENSCCRT00000000033; ENSCCRP00000000012; ENSCCRG00000000033.
DR GeneID; 807769; -.
DR KEGG; ccar:807769; -.
DR CTD; 4540; -.
DR GeneTree; ENSGT00730000111303; -.
DR OrthoDB; 526738at2759; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR InterPro; IPR010934; NADH_DH_su5_C.
DR InterPro; IPR018393; NADHpl_OxRdtase_5_subgr.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR003945; NU5C-like.
DR InterPro; IPR001516; Proton_antipo_N.
DR PANTHER; PTHR42829; PTHR42829; 1.
DR Pfam; PF06455; NADH5_C; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR Pfam; PF00662; Proton_antipo_N; 1.
DR TIGRFAMs; TIGR01974; NDH_I_L; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW Transport; Ubiquinone.
FT CHAIN 1..607
FT /note="NADH-ubiquinone oxidoreductase chain 5"
FT /id="PRO_0000118085"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 44..64
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 88..108
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 118..138
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 139..159
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 172..192
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 213..235
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 243..263
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 274..294
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 303..323
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 326..346
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 372..392
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 415..435
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 450..470
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 484..504
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 587..607
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 607 AA; 67368 MW; DEFC96BEFD956BC5 CRC64;
MTLIMHSSLL LIFFILVYPL LTTLNPNQQD SNMAGMTKTA VSSAFFVSLL PLMIFLNLKT
EGIITNWQWM NTQAFDVNIS FKFDHYSLIF VPIALYVTWS ILEFALWYMH SDPNIDRFFK
YLLTFLVAMI ILVTANNMFQ LFIGWEGVGI MSFLLIGWWH GRADANTAAL QAVIYNRVGD
IGLIMTMAWL AMNLNSWEIQ QIFALSKNFD MTIPLMGLAL AATGKSAQFG LHPWLPVAME
GPTPVSALLH SSTMVVAGIF LLIRLHPRME NNQLALTTCL CLGALTSLFT ATCALTQNDI
KKIVAFSTSS QLGLMMVTIG LNQPQLAFLH ICTHAFFKAM LFLCSGSIIH SLNDEQDIRK
MGGLFNIMPA TSTYFTIGSL ALTGTPFLAG FFSKDAIIEA LNTSYLNAWA LTLTLIATSF
TAVYSFRLVY FVIMGTPRFL PLSPINENNP LVINTIKRLA WGSIIAGLII TQNFPPMKTP
IMTMSITLKM AALMVTIAGL LVAMELANLT SKQVKITPMI STHHFSNMLG FYPMIIHRLI
PKLKLTLGQS AATQLDKTWL ETVGPKGLAL TQMAMAKITN DITRGMIKTY LTIFLLTLIL
ATIPVLL
