ID   NU5M_DASNO              Reviewed;         601 AA.
AC   O21335;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 5;
DE            EC=7.1.1.2;
DE   AltName: Full=NADH dehydrogenase subunit 5;
GN   Name=MT-ND5; Synonyms=MTND5, NADH5, ND5;
OS   Dasypus novemcinctus (Nine-banded armadillo).
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Xenarthra; Cingulata; Dasypodidae; Dasypus.
OX   NCBI_TaxID=9361;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9214749; DOI=10.1093/oxfordjournals.molbev.a025816;
RA   Arnason U., Gullberg A., Janke A.;
RT   "Phylogenetic analyses of mitochondrial DNA suggest a sister group
RT   relationship between Xenarthra (Edentata) and Ferungulates.";
RL   Mol. Biol. Evol. 14:762-768(1997).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) that is believed to belong to the
CC       minimal assembly required for catalysis. Complex I functions in the
CC       transfer of electrons from NADH to the respiratory chain. The immediate
CC       electron acceptor for the enzyme is believed to be ubiquinone (By
CC       similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 5 family. {ECO:0000305}.
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DR   EMBL; Y11832; CAA72521.1; -; Genomic_DNA.
DR   PIR; T11451; T11451.
DR   RefSeq; NP_007469.1; NC_001821.1.
DR   AlphaFoldDB; O21335; -.
DR   SMR; O21335; -.
DR   Ensembl; ENSDNOT00000039339; ENSDNOP00000022874; ENSDNOG00000046561.
DR   GeneID; 808129; -.
DR   KEGG; dnm:808129; -.
DR   CTD; 4540; -.
DR   HOGENOM; CLU_007100_6_0_1; -.
DR   OMA; GVGIMSF; -.
DR   OrthoDB; 526738at2759; -.
DR   GO; GO:0005747; C:mitochondrial respiratory chain complex I; IEA:Ensembl.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR   GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; IEA:Ensembl.
DR   GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; IEA:Ensembl.
DR   InterPro; IPR010934; NADH_DH_su5_C.
DR   InterPro; IPR018393; NADHpl_OxRdtase_5_subgr.
DR   InterPro; IPR001750; ND/Mrp_mem.
DR   InterPro; IPR003945; NU5C-like.
DR   InterPro; IPR001516; Proton_antipo_N.
DR   PANTHER; PTHR42829; PTHR42829; 1.
DR   Pfam; PF06455; NADH5_C; 1.
DR   Pfam; PF00361; Proton_antipo_M; 1.
DR   Pfam; PF00662; Proton_antipo_N; 1.
DR   TIGRFAMs; TIGR01974; NDH_I_L; 1.
PE   3: Inferred from homology;
KW   Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW   Transport; Ubiquinone.
FT   CHAIN           1..601
FT                   /note="NADH-ubiquinone oxidoreductase chain 5"
FT                   /id="PRO_0000118086"
FT   TRANSMEM        3..23
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        36..56
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        84..104
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        114..134
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        140..160
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        171..191
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        201..221
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        240..260
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        272..292
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        324..346
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        365..385
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        404..426
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        456..476
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        483..503
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        581..601
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   601 AA;  67584 MW;  34E635230A2D89C4 CRC64;
     MNLIMPFSII TLTILTIPIM MSYTNKYKTK SYPYHVTSSV SYAFMTSMIP TMMFLLSNQD
     SYISNWHWMT MQTMKLSLSF KLDFFSIIFV SVALFVTWSI MEFSLWYMHS DPYINQFFKY
     LLLFLITMMI LVTANNMFQL FIGWEGVGIM SFLLIGWWYG RTDANTAALQ AILYNRIGDI
     GFILTMAWLL LHLNSWDLQQ IFMLKPTNLL PLLGLLVAAA GKSAQFGLHP WLPSAMEGPT
     PVSALLHSST MVVAGIFLLV RFYPLMQNNP TILTMTLCLG AITTLFTAIC ALTQNDIKKI
     IAFSTSSQLG LMMVTIGINQ PHLAFLHICT HAFFKAMLFM CSGSIIHSLN NEQDIRKMGG
     LLKAMPFTSS CLMIGSLALT GMPFLTGFYS KDLIIESANT SYSNAWALLI TLLATSFTAS
     YSTRLIYFSS LGPPRYLPLI TINENNPNLL KPIKRLALGS IFAGFLISNY IPPLITPQTT
     MPLYMKLSAL AVTIMGFMVA MGLNNITLNL KPERPNPLHS FSSLLGYYPN IIHRTTPYYI
     LMMSQNLASL TDILWLEKLA PKSLSQMQLS ASMITSNQKG LIKLYFMSFI ISMTLATMLI
     I