NU5M_DICCI
ID NU5M_DICCI Reviewed; 668 AA.
AC Q2LCP6;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 21-FEB-2006, sequence version 1.
DT 25-MAY-2022, entry version 55.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 5;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 5;
GN Name=nad5;
OS Dictyostelium citrinum (Slime mold).
OG Mitochondrion.
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=361072;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=18413355; DOI=10.1093/molbev/msn088;
RA Heidel A.J., Gloeckner G.;
RT "Mitochondrial genome evolution in the social amoebae.";
RL Mol. Biol. Evol. 25:1440-1450(2008).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the complex I subunit 5 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DQ336395; ABC60397.1; -; Genomic_DNA.
DR RefSeq; YP_492646.1; NC_007787.2.
DR AlphaFoldDB; Q2LCP6; -.
DR SMR; Q2LCP6; -.
DR GeneID; 3912634; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR InterPro; IPR010934; NADH_DH_su5_C.
DR InterPro; IPR018393; NADHpl_OxRdtase_5_subgr.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR003945; NU5C-like.
DR InterPro; IPR001516; Proton_antipo_N.
DR PANTHER; PTHR42829; PTHR42829; 1.
DR Pfam; PF06455; NADH5_C; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR Pfam; PF00662; Proton_antipo_N; 1.
DR TIGRFAMs; TIGR01974; NDH_I_L; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW Transport; Ubiquinone.
FT CHAIN 1..668
FT /note="NADH-ubiquinone oxidoreductase chain 5"
FT /id="PRO_0000312416"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 31..51
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 81..101
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 111..131
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 133..153
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 178..198
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 211..231
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 251..271
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 283..303
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 311..331
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 339..359
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 375..395
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 421..441
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 462..482
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 519..539
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 566..586
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 629..649
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 650..668
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 668 AA; 75234 MW; EC19A68B740F0A64 CRC64;
MYIINLILPL IGSIITGLFG HKLGNKLSIQ IAVGCMMLTA LSSLYIGYEI LLCNSVVHFK
LSTWMQVGSL NVEYGLLYDS LTSIMIIVIT CISSMVHLYS MDYMKADPHK TRFFSYLSLF
TFFMMLLVTA DNFVQLFFGW EGVGIMSYLL INFWYTRLQA NKSALKAVIL NRFGDFGLFF
GILLVFLVFK SVDFSVIFTV APFITEYTIN LLGYEVNAIT LIGSFIVIGV VGKSAQLGLH
MWLPDAMEGP TPVSALLHAA TMVTAGVFLV LRTSPLLSYS ITILNILTII GALTTLFATT
IGIVQNDIKR VIAYSTCSQL GYMIFACGLL NYNASIYHLT THAFFKALLF LSAGSVIHGL
NDEQDMRKMG GLVNLMPLTY QCMLIGTLAL TGFPFLSGYY SKDIILETSY ATYYWEGTFA
AIIGYVAAFG TTFYSFRLLI LTFFNKPRMQ YKTIAGVHEA STNMVIPLVI LAICSIFIGY
LTKDLFVGLG TPIWNNSFFA YPYNNLILES EVLQRELKLL PLFAFIYGVL TPVLFYFNLK
EDRMVHLIKN PIAKESYFFF VKKWYFDFLS RVLIAVPFFH LSYDVMNKDL DKGLWEQIGV
TGVATALVNE FTEFKLNNEI TLSTYISYIV QAILLIIFVG IFSFMIGFLY VELFVILGAL
YLCLPKIK
