NU5M_DROYA
ID NU5M_DROYA Reviewed; 573 AA.
AC P07706;
DT 01-APR-1988, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1988, sequence version 1.
DT 25-MAY-2022, entry version 109.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 5;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 5;
GN Name=mt:ND5; Synonyms=ND5;
OS Drosophila yakuba (Fruit fly).
OG Mitochondrion.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7245;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=6328435; DOI=10.1093/nar/12.9.3747;
RA Clary D.O., Wahleithner J.A., Wolstenholme D.R.;
RT "Sequence and arrangement of the genes for cytochrome b, URF1, URF4L, URF4,
RT URF5, URF6 and five tRNAs in Drosophila mitochondrial DNA.";
RL Nucleic Acids Res. 12:3747-3762(1984).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2317.6 Ivory Coast;
RX PubMed=3001325; DOI=10.1007/bf02099755;
RA Clary D.O., Wolstenholme D.R.;
RT "The mitochondrial DNA molecular of Drosophila yakuba: nucleotide sequence,
RT gene organization, and genetic code.";
RL J. Mol. Evol. 22:252-271(1985).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 304-573.
RX PubMed=6324117; DOI=10.1093/nar/12.5.2367;
RA Clary D.O., Wolstenholme D.R.;
RT "A cluster of six tRNA genes in Drosophila mitochondrial DNA that includes
RT a gene for an unusual tRNAserAGY.";
RL Nucleic Acids Res. 12:2367-2379(1984).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the complex I subunit 5 family. {ECO:0000305}.
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DR EMBL; X00432; CAA25131.1; -; Genomic_DNA.
DR EMBL; X03240; CAA26992.1; -; Genomic_DNA.
DR PIR; H25797; H25797.
DR RefSeq; NP_006909.1; NC_001322.1.
DR AlphaFoldDB; P07706; -.
DR SMR; P07706; -.
DR GeneID; 807625; -.
DR KEGG; dya:ND5; -.
DR CTD; 4540; -.
DR FlyBase; FBgn0013205; Dyak\mt:ND5.
DR ChiTaRS; ND5; fly.
DR Proteomes; UP000002282; Mitochondrion.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR InterPro; IPR010934; NADH_DH_su5_C.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR003945; NU5C-like.
DR InterPro; IPR001516; Proton_antipo_N.
DR PANTHER; PTHR42829; PTHR42829; 1.
DR Pfam; PF06455; NADH5_C; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR Pfam; PF00662; Proton_antipo_N; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW Transport; Ubiquinone.
FT CHAIN 1..573
FT /note="NADH-ubiquinone oxidoreductase chain 5"
FT /id="PRO_0000118091"
FT TRANSMEM 4..24
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 44..64
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 85..105
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 106..126
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 147..167
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 170..190
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 212..234
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 239..259
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 268..288
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 294..314
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 337..357
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 377..396
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 422..442
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 452..472
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 487..507
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 552..572
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 573 AA; 65104 MW; 1474B176B0AF1C72 CRC64;
MCSISFINLI SISLTCFLLS LYYLLNNMVY FIEWEVVSLN SMSIVMTFLF DWMSLLFMSF
VLMIASLVIF YSKEYMESDE NINRFIMLVL MFVLSMMLLI ISPNLVSILL GWDGLGLVSY
CLVIYFQNIK SYNAGMLTAL SNRIGDVALL LAIAWMLNYG SWNYIFYLEV MQNEFSMLMI
GSLVMLAAMT KSAQIPFSSW LPAAMAAPTP VSALVHSSTL VTAGVYLLIR FNIVLSTSWL
GQLLLLLSGL TMFMAGLGAN FEFDLKKIIA LSTLSQLGLM MSILSMGFYK LAMFHLLTHA
LFKALLFMCA GAIIHNMNNS QDIRLMGGLS IHMPLTSACF NVSNLALCGM PFLAGFYSKD
MILEIVSISN INMFSFFLYF FSTGLTVSYS FRLVYYSMTG DLNCGSLNML NDESWVMLRG
MLGLLFMSII GGSMLNWLIF PFPYMICLPG YLKMLTLFVC IVGGLFGYLI SISNLYSLNK
SLLNYNLTLF LGSMWFMPYI STYGMIFYPL NYGQLVVKSF DQGWSEYFGG QHLYYKLSNY
SKTLFLMHNN SLKIYLMLFV FWIMILFSFL LFL
