NU5M_EMEND
ID NU5M_EMEND Reviewed; 657 AA.
AC P11628; Q00181;
DT 01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 2.
DT 25-MAY-2022, entry version 85.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 5;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 5;
GN Name=nd5; Synonyms=ndhE;
OS Emericella nidulans (Aspergillus nidulans).
OG Mitochondrion.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Nidulantes.
OX NCBI_TaxID=162425;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=yA2 pyroA4 cnxC3;
RX PubMed=2662141; DOI=10.1093/nar/17.11.4371;
RA Brown T.A., Constable A., Ray J.A., Waring R.B., Scazzocchio C.,
RA Davies R.W.;
RT "Nucleotide sequence of the Aspergillus nidulans mitochondrial gene for
RT subunit 5 of NADH dehydrogenase.";
RL Nucleic Acids Res. 17:4371-4371(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 316-349.
RC STRAIN=NRRL 322;
RA Luo X., Khanh N.Q., Wientjes F.J.;
RL Submitted (NOV-1991) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the complex I subunit 5 family. {ECO:0000305}.
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DR EMBL; X15011; CAA33116.1; -; Genomic_DNA.
DR EMBL; X62993; CAA44727.1; -; Genomic_DNA.
DR PIR; S04724; S04724.
DR PIR; S18161; S18161.
DR AlphaFoldDB; P11628; -.
DR SMR; P11628; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR InterPro; IPR010934; NADH_DH_su5_C.
DR InterPro; IPR018393; NADHpl_OxRdtase_5_subgr.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR003945; NU5C-like.
DR InterPro; IPR001516; Proton_antipo_N.
DR PANTHER; PTHR42829; PTHR42829; 1.
DR Pfam; PF06455; NADH5_C; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR Pfam; PF00662; Proton_antipo_N; 1.
DR TIGRFAMs; TIGR01974; NDH_I_L; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW Transport; Ubiquinone.
FT CHAIN 1..657
FT /note="NADH-ubiquinone oxidoreductase chain 5"
FT /id="PRO_0000118093"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 30..50
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 81..101
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 113..133
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 135..155
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 177..197
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 211..233
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 241..261
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 274..294
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 309..329
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 330..350
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 364..384
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 408..428
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 451..471
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 475..497
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 509..529
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 610..630
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 637..657
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 657 AA; 73362 MW; B5BB679A151E7287 CRC64;
MYLTLIILPL LGSIVSGFFG RKVGVTGAHL ITCVSVVTTT ILAILAFLEV GFNNIPVTIN
IARWLDVESL YVLWIFRFDS LTVSMFITVL IVSSLVHIYS ISYMSHDPHN QRFFSYLSLF
TFMMIILVTG NNYLIMFVGW EVVGVCSYLL VNFWFTRIAA NQSSLSALLT NRVGDTLLTV
GMFAILWSFG NIDYSTVFAL APYYNENIIT LIGICLLIGA TAKSSQVGLH IWLPQAMEGP
TPVSALIHAA TMVTAGVYLL MRSSPLIEYS STVLVLCLWL GAITTVFSSL IGLFQQILKK
LFAYSTMQLG MMVIAVGLSS YNLALFHLVN HAFYKALLFL GAGSVIHAVA DNQDFRKYGG
LREFLPLTYY VMLIASLSLV AVPFMTGFYS KDYILESAYG QYYLSSTIVY FVATIGAMFT
TLYSAKVLYL TFLTNPNGPL VNYKHAHEGD LFMTTPLIIL AIIYIHSGYI TKDIFIGLGT
GFSLINSYYS PSHEIMLDTE FAVPTLFKLL PFILSISLSV ISVLLSEFLP KLLINFKFSR
LGYNIFSFFN QRFYIELFYN KYIVEGVLKL GGQTSKSLDK GSVELLGPYG LEKALLSLSN
SIGKLSTSVV TTYALYILIG LIFYISLLYF SYNDNNLFIL VIFTLFVLLN NNIINKF
