NU5M_EQUAS
ID NU5M_EQUAS Reviewed; 606 AA.
AC P92485;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1997, sequence version 1.
DT 25-MAY-2022, entry version 89.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 5;
DE EC=7.1.1.2 {ECO:0000250|UniProtKB:P03915};
DE AltName: Full=NADH dehydrogenase subunit 5;
GN Name=MT-ND5; Synonyms=MTND5, NADH5, ND5;
OS Equus asinus (Donkey) (Equus africanus asinus).
OG Mitochondrion.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9793;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC TISSUE=Kidney;
RX PubMed=8875857; DOI=10.1007/bf02337515;
RA Xu X., Gullberg A., Arnason U.;
RT "The complete mitochondrial DNA (mtDNA) of the donkey and mtDNA comparisons
RT among four closely related mammalian species-pairs.";
RL J. Mol. Evol. 43:438-446(1996).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC NADH through the respiratory chain, using ubiquinone as an electron
CC acceptor. Essential for the catalytic activity and assembly of complex
CC I. {ECO:0000250|UniProtKB:P03915}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC Evidence={ECO:0000250|UniProtKB:P03915};
CC -!- SUBUNIT: Core subunit of respiratory chain NADH dehydrogenase (Complex
CC I) which is composed of 45 different subunits.
CC {ECO:0000250|UniProtKB:P03920}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:P03920}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the complex I subunit 5 family. {ECO:0000305}.
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DR EMBL; X97337; CAA66024.1; -; Genomic_DNA.
DR PIR; T11373; T11373.
DR RefSeq; NP_007391.1; NC_001788.1.
DR AlphaFoldDB; P92485; -.
DR SMR; P92485; -.
DR GeneID; 808058; -.
DR KEGG; eai:808058; -.
DR CTD; 4540; -.
DR OrthoDB; 526738at2759; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; ISS:UniProtKB.
DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; ISS:UniProtKB.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR InterPro; IPR010934; NADH_DH_su5_C.
DR InterPro; IPR018393; NADHpl_OxRdtase_5_subgr.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR003945; NU5C-like.
DR InterPro; IPR001516; Proton_antipo_N.
DR PANTHER; PTHR42829; PTHR42829; 1.
DR Pfam; PF06455; NADH5_C; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR Pfam; PF00662; Proton_antipo_N; 1.
DR TIGRFAMs; TIGR01974; NDH_I_L; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW Transport; Ubiquinone.
FT CHAIN 1..606
FT /note="NADH-ubiquinone oxidoreductase chain 5"
FT /id="PRO_0000118094"
FT TRANSMEM 4..24
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 38..58
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..107
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 117..137
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 171..191
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 211..233
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 241..261
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..293
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 301..320
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 325..347
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 366..386
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 413..433
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 457..477
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 488..508
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 584..604
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 606 AA; 68254 MW; C5E4A3D1C7E943F6 CRC64;
MNMFSSLMLA SLSVLTLPIM SSILNTHKNS TYPHHVKNII SYAFITSLIP TMMFIHSGQE
TIISNWHWMT IQTLKLSLSF KLDYFSMIFV PVALFVTWSI MEFSLWYMHS DPYITRFFKY
LLTFLITMMI LVTANNLFQL FIGWEGVGIM SFLLIGWWYG RTDANTAALQ AILYNRIGDI
GFIMAMAWFL FNTNTWDLQQ IFMLDPNLTN LPLLGLLLAA TGKSAQFGLH PWLPSAMEGP
TPVSALLHSS TMVVAGVFLL IRFHPLMENN KTIQSLTLCL GAITTLFTAI CALTQNDIKK
IIAFSTSSQL GLMIVTIGIN QPYLAFLHIC THAFFKAMLF MCSGSIIHSL NDEQDIRKTG
GLFNAMPFTT TSLIIGSLAL TGMPFLTGFY SKDLIIETAN TSYTNAWALL MTLIATSLTA
VYSTRIIFFA LLGQPRFLPL TTINENNPFL INSIKRLLIG SIFAGFFISN NIYPTTIPEM
TMPIYMKLTA LTVTILGFTL ALELSLITHN LKLEHPTNMF KFSNLLGYYP TIMHRLPPLA
NLSMSQKSAS LLLDSIWLEN ILPKSISQFQ MKTSILISTQ KGQIKLYFLS FLITLTLSML
LFNLHE
