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NU5M_FELCA
ID   NU5M_FELCA              Reviewed;         606 AA.
AC   P48921;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 5;
DE            EC=7.1.1.2 {ECO:0000250|UniProtKB:P03915};
DE   AltName: Full=NADH dehydrogenase subunit 5;
GN   Name=MT-ND5; Synonyms=MTND5, NADH5, ND5;
OS   Felis catus (Cat) (Felis silvestris catus).
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX   NCBI_TaxID=9685;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Abyssinian {ECO:0000312|Proteomes:UP000011712}; TISSUE=Blood;
RX   PubMed=8660972; DOI=10.1006/geno.1996.0188;
RA   Lopez J.V., Cevario S., O'Brien S.J.;
RT   "Complete nucleotide sequences of the domestic cat (Felis catus)
RT   mitochondrial genome and a transposed mtDNA tandem repeat (Numt) in the
RT   nuclear genome.";
RL   Genomics 33:229-246(1996).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC       NADH through the respiratory chain, using ubiquinone as an electron
CC       acceptor. Essential for the catalytic activity and assembly of complex
CC       I. {ECO:0000250|UniProtKB:P03915}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC         Evidence={ECO:0000250|UniProtKB:P03915};
CC   -!- SUBUNIT: Core subunit of respiratory chain NADH dehydrogenase (Complex
CC       I) which is composed of 45 different subunits.
CC       {ECO:0000250|UniProtKB:P03920}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:P03920}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 5 family. {ECO:0000305}.
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DR   EMBL; U20753; AAC48579.1; -; Genomic_DNA.
DR   PIR; T11412; T11412.
DR   RefSeq; NP_008261.1; NC_001700.1.
DR   AlphaFoldDB; P48921; -.
DR   SMR; P48921; -.
DR   STRING; 9685.ENSFCAP00000025719; -.
DR   Ensembl; ENSFCAT00000032659; ENSFCAP00000025719; ENSFCAG00000032074.
DR   GeneID; 807929; -.
DR   KEGG; fca:807929; -.
DR   CTD; 4540; -.
DR   VGNC; VGNC:80937; MT-ND5.
DR   eggNOG; KOG4668; Eukaryota.
DR   GeneTree; ENSGT00730000111303; -.
DR   HOGENOM; CLU_007100_6_0_1; -.
DR   InParanoid; P48921; -.
DR   OMA; GVGIMSF; -.
DR   OrthoDB; 526738at2759; -.
DR   Proteomes; UP000011712; Mitochondrion.
DR   Bgee; ENSFCAG00000032074; Expressed in embryonic head and 9 other tissues.
DR   GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR   GO; GO:0005747; C:mitochondrial respiratory chain complex I; IBA:GO_Central.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; ISS:UniProtKB.
DR   GO; GO:0003954; F:NADH dehydrogenase activity; IBA:GO_Central.
DR   GO; GO:0015990; P:electron transport coupled proton transport; IBA:GO_Central.
DR   GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; ISS:UniProtKB.
DR   GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR   InterPro; IPR010934; NADH_DH_su5_C.
DR   InterPro; IPR018393; NADHpl_OxRdtase_5_subgr.
DR   InterPro; IPR001750; ND/Mrp_mem.
DR   InterPro; IPR003945; NU5C-like.
DR   InterPro; IPR001516; Proton_antipo_N.
DR   PANTHER; PTHR42829; PTHR42829; 1.
DR   Pfam; PF06455; NADH5_C; 1.
DR   Pfam; PF00361; Proton_antipo_M; 1.
DR   Pfam; PF00662; Proton_antipo_N; 1.
DR   TIGRFAMs; TIGR01974; NDH_I_L; 1.
PE   3: Inferred from homology;
KW   Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   NAD; Reference proteome; Respiratory chain; Translocase; Transmembrane;
KW   Transmembrane helix; Transport; Ubiquinone.
FT   CHAIN           1..606
FT                   /note="NADH-ubiquinone oxidoreductase chain 5"
FT                   /id="PRO_0000118095"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        43..63
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        88..108
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        117..137
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        140..160
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        171..191
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        209..229
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        241..261
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        273..293
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        310..330
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        366..386
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        413..433
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        457..477
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        488..508
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        513..533
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        582..602
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   606 AA;  68410 MW;  C51A5282F68B7CF9 CRC64;
     MNLFTPLMLT AMFILLLPII MSNTQLYKNS LYPHYVKTTI SYAFIISMIP TMMFISSGQE
     AIISNWHWLS IQTLKLSLSF KMDYFSTIFI PVALFVTWSI MEFSMWYMHS DPYINRFFKY
     LLMFLITMMI LVTANNLFQL FIGWEGVGIM SFLLIGWWYG RADANTAALQ AILYNRIGDV
     GFIMAMAWFL TNSNAWDFQQ IFITQHENLN IPLLGLLLAA TGKSAQFGLH PWLPSAMEGP
     TPVSALLHSS TMVVAGVFLL IRFYPLMEQN KTMQTLTLCL GAITTLFTAI CALTQNDIKK
     VVAFSTSSQL GLMIVTIGIN QPYLAFLHIC THAFFKAMLF MCSGSIIHSL NDEQDIRKMG
     GLYKPMPFTT TSLIIGSLAL TGMPFLTGFY SKDLIIETAN TSYTNAWALL ITLIATSLTA
     AYSTRIMFFV LLGQPRFNTL NLINENNTHL INSIKRLLIG SIFAGYLISY NIPPTTIPQM
     TMPYYLKLTA LAVTIAGFIL ALELNLAAKN LKFMYPSNLF KFSNLLGYFP IVMHRLPSKM
     SLTMSQKSAS MLLDMIWLEN VLPKSISLFQ MKMSTTVSNQ KGLVKLYFLS FMITLALSLI
     LLNSHE
 
 
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