NU5M_FORLA
ID NU5M_FORLA Reviewed; 612 AA.
AC P34195;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1994, sequence version 1.
DT 25-MAY-2022, entry version 86.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 5;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 5;
GN Name=MT-ND5; Synonyms=MTND5, NADH5, ND5;
OS Formosania lacustris (Oriental stream loach) (Crossostoma lacustre).
OG Mitochondrion.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Gastromyzontidae; Formosania.
OX NCBI_TaxID=7980;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1408800; DOI=10.1093/nar/20.18.4853;
RA Tzeng C.-S., Hui C.-F., Shen S.-C., Huang P.C.;
RT "The complete nucleotide sequence of the Crossostoma lacustre mitochondrial
RT genome: conservation and variations among vertebrates.";
RL Nucleic Acids Res. 20:4853-4858(1992).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the complex I subunit 5 family. {ECO:0000305}.
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DR EMBL; M91245; AAB96821.1; -; Genomic_DNA.
DR PIR; S35471; S35471.
DR RefSeq; NP_008313.1; NC_001727.1.
DR AlphaFoldDB; P34195; -.
DR SMR; P34195; -.
DR GeneID; 807993; -.
DR CTD; 4540; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR InterPro; IPR010934; NADH_DH_su5_C.
DR InterPro; IPR018393; NADHpl_OxRdtase_5_subgr.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR003945; NU5C-like.
DR InterPro; IPR001516; Proton_antipo_N.
DR PANTHER; PTHR42829; PTHR42829; 1.
DR Pfam; PF06455; NADH5_C; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR Pfam; PF00662; Proton_antipo_N; 1.
DR TIGRFAMs; TIGR01974; NDH_I_L; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW Transport; Ubiquinone.
FT CHAIN 1..612
FT /note="NADH-ubiquinone oxidoreductase chain 5"
FT /id="PRO_0000118082"
FT TRANSMEM 4..24
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 40..60
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 92..112
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 122..142
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 145..165
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 176..196
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 216..238
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 247..267
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 278..298
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 307..327
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 330..350
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 376..396
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 410..430
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 454..474
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 494..514
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 589..611
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 612 AA; 67582 MW; F32FE0FA648D0165 CRC64;
MHPTPLILSS SLLLVIIILI YPVLTSLNPN PQNPKWATSH VKTAVSSAFL ISLLPLAVFL
DQGTETIVTN WHWMNTTMFD INISFKFDYY SLVFTPIALY VTWSILEFAS WYMHADPYVN
RFFKYLLTFL IAMITLVTAN NMFQLFIGWE GVGIMSFLLI GWWYGRADAN TAALQAWIYN
RVGDIGLIMS MAWLAMNLNS WEIQQIFFLS KDFDMTLPLM GLILAATGKS AQFGLHPWLP
AAMEGPTPVS ALLHSSTMVV AGIFLLIRLH AIMENNQLAL TTCLCLGALT SLFTAACALT
QNDIKKIVAF STSSQLGLMM VTIGLNQPQL AFLHICTHAF FKAMLFLCSG SIIHSLNDEQ
DIRKMGGLQN LLPFTSTCLT IGSLALTGTP FLAGFFSKDA IIEAMNTSYL NAWALTLTLI
ATSFTAVYSF RVVFFVSMGT PRFLPLSPIN ENNPAVINPI KRLAWGSIIA GLIITSNLLP
SKSPVMTMPP TLKMAALMVT AIGLFTAMEL ATLTSKQYKT NPITQTHHFS NMLGFFPSVV
HRLMKKLNLT LGQLAATQMV DQTWFEAAGP KGASSTQIKM AKITSDTQRG MIKTYLTIFL
LTTALATRLA TI
