ID   NU5M_GADMO              Reviewed;         612 AA.
AC   P55782;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 5;
DE            EC=7.1.1.2;
DE   AltName: Full=NADH dehydrogenase subunit 5;
GN   Name=MT-ND5; Synonyms=MTND5, NADH5, ND5;
OS   Gadus morhua (Atlantic cod).
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Zeiogadaria; Gadariae; Gadiformes; Gadoidei; Gadidae; Gadus.
OX   NCBI_TaxID=8049;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Norwegian coastal 1;
RX   PubMed=8817926;
RA   Johansen S., Bakke I.;
RT   "The complete mitochondrial DNA sequence of Atlantic cod (Gadus morhua):
RT   relevance to taxonomic studies among codfishes.";
RL   Mol. Mar. Biol. Biotechnol. 5:203-214(1996).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) that is believed to belong to the
CC       minimal assembly required for catalysis. Complex I functions in the
CC       transfer of electrons from NADH to the respiratory chain. The immediate
CC       electron acceptor for the enzyme is believed to be ubiquinone (By
CC       similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 5 family. {ECO:0000305}.
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DR   EMBL; X99772; CAA68115.1; -; Genomic_DNA.
DR   PIR; T11830; T11830.
DR   RefSeq; NP_007819.1; NC_002081.1.
DR   AlphaFoldDB; P55782; -.
DR   SMR; P55782; -.
DR   GeneID; 808457; -.
DR   CTD; 4540; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR   GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR   InterPro; IPR010934; NADH_DH_su5_C.
DR   InterPro; IPR018393; NADHpl_OxRdtase_5_subgr.
DR   InterPro; IPR001750; ND/Mrp_mem.
DR   InterPro; IPR003945; NU5C-like.
DR   InterPro; IPR001516; Proton_antipo_N.
DR   PANTHER; PTHR42829; PTHR42829; 1.
DR   Pfam; PF06455; NADH5_C; 1.
DR   Pfam; PF00361; Proton_antipo_M; 1.
DR   Pfam; PF00662; Proton_antipo_N; 1.
DR   TIGRFAMs; TIGR01974; NDH_I_L; 1.
PE   3: Inferred from homology;
KW   Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW   Transport; Ubiquinone.
FT   CHAIN           1..612
FT                   /note="NADH-ubiquinone oxidoreductase chain 5"
FT                   /id="PRO_0000118096"
FT   TRANSMEM        12..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        48..68
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        92..112
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        117..137
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        142..162
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        176..196
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        247..267
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        279..299
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        307..327
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        330..350
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        376..396
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        419..439
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        463..483
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        494..514
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        591..611
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   612 AA;  66949 MW;  4A639F2F51EDA158 CRC64;
     MHPTTLMYTS SLLLMFAVLL YPLLVTFTSL PLNNDWASSH AKTAVKSAFL ISLAPLSLFL
     STGMEAVTSS WTWMVTTTLD ITLSFKFDHY SIIFIPIALY VTWSILEFAT WYMHSDPFMN
     RFFKYLLTFL VAMLILVSAN NLFQLFIGWE GVGIMSFLLI GWWHGRADAN TAALQAVLYN
     RVGDIGLILG MAWLATNVNS WDIQQMFILS KNLDMTLPLL GLILAATGKS AQFGLHPWLP
     AAMEGPTPVS ALLHSSTMVV AGIFLLIRMS PLMENNQTAL TLCLCLGALT TMFTATCALT
     QNDIKKIVAF STSSQLGLMM VTIGLNQPQL AFLHICTHAF FKAMLFLCSG SVIHSLNDEQ
     DIRKMGGLHH LAPFTSSCLT VGSLALTGTP FLAGFFSKDA IIEALNTSHV NAWALTLTLI
     ATSFTAIYSL RVIFFVTMGT PRFLPLSPIN ENNPAVINPL KRLAWGGIFG GLLVMLNINL
     FKTPVLTMPA ELKLAALAVS ILGLLTALEL ATLTSKQFKV TPLRTPHHFS TSLGFVPAII
     HRQIPQLSLL LGQKIASQMV DQTWLEKTGP KAIANATTPL ASATSNMQQG LIKTYLTLFL
     MTLVLVTLIS AT