ID   NU5M_GLIGL              Reviewed;         603 AA.
AC   O63908;
DT   27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 5;
DE            EC=7.1.1.2;
DE   AltName: Full=NADH dehydrogenase subunit 5;
GN   Name=MT-ND5; Synonyms=MTND5, NADH5, ND5;
OS   Glis glis (Fat dormouse) (Myoxus glis).
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Gliridae;
OC   Glirinae; Glis.
OX   NCBI_TaxID=41261;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9580978; DOI=10.1093/oxfordjournals.molbev.a025949;
RA   Reyes A., Pesole G., Saccone C.;
RT   "Complete mitochondrial DNA sequence of the fat dormouse, Glis glis:
RT   further evidence of rodent paraphyly.";
RL   Mol. Biol. Evol. 15:499-505(1998).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) that is believed to belong to the
CC       minimal assembly required for catalysis. Complex I functions in the
CC       transfer of electrons from NADH to the respiratory chain. The immediate
CC       electron acceptor for the enzyme is believed to be ubiquinone (By
CC       similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 5 family. {ECO:0000305}.
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DR   EMBL; AJ001562; CAA04840.1; -; Genomic_DNA.
DR   PIR; T11399; T11399.
DR   RefSeq; NP_007520.1; NC_001892.1.
DR   AlphaFoldDB; O63908; -.
DR   SMR; O63908; -.
DR   GeneID; 808180; -.
DR   CTD; 4540; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR   GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR   InterPro; IPR010934; NADH_DH_su5_C.
DR   InterPro; IPR018393; NADHpl_OxRdtase_5_subgr.
DR   InterPro; IPR001750; ND/Mrp_mem.
DR   InterPro; IPR003945; NU5C-like.
DR   InterPro; IPR001516; Proton_antipo_N.
DR   PANTHER; PTHR42829; PTHR42829; 1.
DR   Pfam; PF06455; NADH5_C; 1.
DR   Pfam; PF00361; Proton_antipo_M; 1.
DR   Pfam; PF00662; Proton_antipo_N; 1.
DR   TIGRFAMs; TIGR01974; NDH_I_L; 1.
PE   3: Inferred from homology;
KW   Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW   Transport; Ubiquinone.
FT   CHAIN           1..603
FT                   /note="NADH-ubiquinone oxidoreductase chain 5"
FT                   /id="PRO_0000118115"
FT   TRANSMEM        3..23
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        39..59
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        87..107
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        117..137
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        140..160
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        171..191
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        210..230
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        241..261
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        272..292
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        301..320
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        325..347
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        360..382
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        411..431
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        457..477
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        482..502
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        583..603
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   603 AA;  68238 MW;  9AC8D41FCFB9E575 CRC64;
     MNLFSSFTLM TFSILLYPIL LSFTDQYNNN LFPNHVKTSI ICAFLFSLIP TLMFINSGYD
     MIISNWHWMT IQTLNLTMSF KMDMFSMMFV PVALFVTWSI MEFSLWYMHS DPYINRFFKY
     LLLFLITMII LVTANNLFQL FIGWEGVGIM SFLLIGWWYG RPDANTAALQ AVLYNRIGDI
     GFVLSMAWFL MHSSSWEFQQ RFSSQNSSNI LPLLGLILAA AGKSAQFGLH PWLPSAMEGP
     TPVSALLHSS TMVVAGVFLL IRFYPFIKNN QLVQSIIMCL GAITTLFTAI CALTQNDIKK
     IIAFSTSSQL GLMMVTIGIN QPYLAFFHIC THAFFKAMLF MCSGSIIHNL NDEQDIRKMG
     GLFKTLPFTS SELTVGSLTL TGTPYLTGFY SKDLIIESAN TSYTNAWALS ITLIATSLTA
     IYSTRIIFLL IRSKPRFVPL SPINENNPLL NNAIKRLLIG SIFAGFLITN NMTPMSIQQM
     TMPWYLKLTA LIVTILGFMM AMELNNLSLY FKYKTTSQHV KFSNLLGFFP STMHRLFPNT
     NLLISHNSAS TLLDLIWLEK STPKLLSSTQ LMDSTLSSNQ TGLIKLYFLS FLLSMLMVTM
     LII