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NU5M_GORGO
ID   NU5M_GORGO              Reviewed;         603 AA.
AC   P03917;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 2.
DT   25-MAY-2022, entry version 104.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 5;
DE            EC=7.1.1.2 {ECO:0000250|UniProtKB:P03915};
DE   AltName: Full=NADH dehydrogenase subunit 5;
GN   Name=MT-ND5; Synonyms=MTND5, NADH5, ND5;
OS   Gorilla gorilla gorilla (Western lowland gorilla).
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Gorilla.
OX   NCBI_TaxID=9595;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7530363; DOI=10.1073/pnas.92.2.532;
RA   Horai S., Hayasaka K., Kondo R., Tsugane K., Takahata N.;
RT   "Recent African origin of modern humans revealed by complete sequences of
RT   hominoid mitochondrial DNAs.";
RL   Proc. Natl. Acad. Sci. U.S.A. 92:532-536(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-79.
RX   PubMed=6284948; DOI=10.1007/bf01734101;
RA   Brown W.M., Prager E.M., Wang A., Wilson A.C.;
RT   "Mitochondrial DNA sequences of primates: tempo and mode of evolution.";
RL   J. Mol. Evol. 18:225-239(1982).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC       NADH through the respiratory chain, using ubiquinone as an electron
CC       acceptor. Essential for the catalytic activity and assembly of complex
CC       I. {ECO:0000250|UniProtKB:P03915}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC         Evidence={ECO:0000250|UniProtKB:P03915};
CC   -!- SUBUNIT: Core subunit of respiratory chain NADH dehydrogenase (Complex
CC       I) which is composed of 45 different subunits.
CC       {ECO:0000250|UniProtKB:P03920}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:P03920}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 5 family. {ECO:0000305}.
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DR   EMBL; D38114; BAA07306.1; -; Genomic_DNA.
DR   EMBL; V00658; CAA24023.1; -; Genomic_DNA.
DR   PIR; A00447; A00447.
DR   PIR; B59154; B59154.
DR   PIR; T14026; T14026.
DR   RefSeq; NP_008222.1; NC_001645.1.
DR   AlphaFoldDB; P03917; -.
DR   SMR; P03917; -.
DR   STRING; 9593.ENSGGOP00000022538; -.
DR   GeneID; 807891; -.
DR   CTD; 4540; -.
DR   eggNOG; KOG4668; Eukaryota.
DR   InParanoid; P03917; -.
DR   Proteomes; UP000001519; Mitochondrion.
DR   GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR   GO; GO:0005747; C:mitochondrial respiratory chain complex I; IBA:GO_Central.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; ISS:UniProtKB.
DR   GO; GO:0003954; F:NADH dehydrogenase activity; IBA:GO_Central.
DR   GO; GO:0015990; P:electron transport coupled proton transport; IBA:GO_Central.
DR   GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; ISS:UniProtKB.
DR   GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR   InterPro; IPR010934; NADH_DH_su5_C.
DR   InterPro; IPR018393; NADHpl_OxRdtase_5_subgr.
DR   InterPro; IPR001750; ND/Mrp_mem.
DR   InterPro; IPR003945; NU5C-like.
DR   InterPro; IPR001516; Proton_antipo_N.
DR   PANTHER; PTHR42829; PTHR42829; 1.
DR   Pfam; PF06455; NADH5_C; 1.
DR   Pfam; PF00361; Proton_antipo_M; 1.
DR   Pfam; PF00662; Proton_antipo_N; 1.
DR   TIGRFAMs; TIGR01974; NDH_I_L; 1.
PE   3: Inferred from homology;
KW   Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   NAD; Reference proteome; Respiratory chain; Translocase; Transmembrane;
KW   Transmembrane helix; Transport; Ubiquinone.
FT   CHAIN           1..603
FT                   /note="NADH-ubiquinone oxidoreductase chain 5"
FT                   /id="PRO_0000118097"
FT   TRANSMEM        4..24
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        38..58
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        87..107
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        114..134
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        140..160
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        171..191
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        210..230
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        241..261
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        272..292
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        301..320
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        325..347
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        370..390
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        407..429
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        457..477
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        482..502
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        537..557
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        582..602
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   603 AA;  67195 MW;  255046545539F5B6 CRC64;
     MTMYATMTTL ALTSLIPPIL TTFINPNKKS SYPHYVKSIV ASTFIISLFP TTMFLCLDQE
     AIISSWHWAT TQTIQLSLSF KLDYFSMMFI PVALFVTWSI MEFSLWYMNS DPNINQFFKY
     LLIFLITMLI LVTANNLFQL FIGWEGVGIM SFLLIGWWYA RTDANTAAVQ AILYNRIGDI
     GFILALAWFL LHSNSWDPQQ MSLLNTNPNL IPLLGFLLAA AGKSAQLGLH PWLPSAMEGP
     TPVSALLHSS TMVVAGVFLL IRFRHLAENN SLAQTLTLCL GAITTLFAAV CALTQNDIKK
     IVAFSTSSQL GLMVATIGIG QPHLAFLHIC THAFFKAMLF MCSGSIIHNL NNEQDIRKMG
     GLLKAMPLTS TSLAIGSLAL MGMPFLTGFY SKDLIIETAN MSHTNAWALS IILIATSLTS
     AYSTRMILLT LTGQPRFPTF ANINENYSTL LNPIKRLTIG SLFAGFFITN NILPTSVPQM
     TIPLYLKLTA LSITLLGLLT ALDLNYLTNK LKMKHPPHTF YFSNMLGFYP NITHRTIPYL
     GLLMSQNLPL LLLDLIWLEK LLPKTISQHQ ISASITTSTQ KGLIKLYFLS FFFPLLLILL
     LIT
 
 
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