NU5M_HALGR
ID NU5M_HALGR Reviewed; 609 AA.
AC P38602;
DT 01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1994, sequence version 1.
DT 25-MAY-2022, entry version 82.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 5;
DE EC=7.1.1.2 {ECO:0000250|UniProtKB:P03915};
DE AltName: Full=NADH dehydrogenase subunit 5;
GN Name=MT-ND5; Synonyms=MTND5, NADH5, ND5;
OS Halichoerus grypus (Gray seal) (Phoca grypus).
OG Mitochondrion.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Phocidae; Halichoerus.
OX NCBI_TaxID=9711;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8308902; DOI=10.1007/bf00178862;
RA Arnason U., Gullberg A., Johnsson E., Ledje C.;
RT "The nucleotide sequence of the mitochondrial DNA molecule of the grey
RT seal, Halichoerus grypus, and a comparison with mitochondrial sequences of
RT other true seals.";
RL J. Mol. Evol. 37:323-330(1993).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC NADH through the respiratory chain, using ubiquinone as an electron
CC acceptor. Essential for the catalytic activity and assembly of complex
CC I. {ECO:0000250|UniProtKB:P03915}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC Evidence={ECO:0000250|UniProtKB:P03915};
CC -!- SUBUNIT: Core subunit of respiratory chain NADH dehydrogenase (Complex
CC I) which is composed of 45 different subunits.
CC {ECO:0000250|UniProtKB:P03920}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:P03920}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the complex I subunit 5 family. {ECO:0000305}.
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DR EMBL; X72004; CAA50887.1; -; Genomic_DNA.
DR PIR; S41845; S41845.
DR RefSeq; NP_007079.1; NC_001602.1.
DR AlphaFoldDB; P38602; -.
DR SMR; P38602; -.
DR GeneID; 807751; -.
DR CTD; 4540; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; ISS:UniProtKB.
DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; ISS:UniProtKB.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR InterPro; IPR010934; NADH_DH_su5_C.
DR InterPro; IPR018393; NADHpl_OxRdtase_5_subgr.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR003945; NU5C-like.
DR InterPro; IPR001516; Proton_antipo_N.
DR PANTHER; PTHR42829; PTHR42829; 1.
DR Pfam; PF06455; NADH5_C; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR Pfam; PF00662; Proton_antipo_N; 1.
DR TIGRFAMs; TIGR01974; NDH_I_L; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW Transport; Ubiquinone.
FT CHAIN 1..609
FT /note="NADH-ubiquinone oxidoreductase chain 5"
FT /id="PRO_0000118098"
FT TRANSMEM 3..23
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 41..61
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 90..110
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 115..135
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 174..194
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 214..236
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 244..264
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 276..296
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 304..323
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 328..350
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 368..388
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 410..432
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 460..480
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 491..511
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 585..605
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 609 AA; 68656 MW; F1C686CCCC9FC241 CRC64;
MKVINLFASS IITTLSMLTL PIVLTSTSIY KNKLYPQYVK TAISYAFMIS MIPTTMFIYS
GQEMIISNWH WMTIQTMKLT LSFKLDHFSM IFVPVALFVT WSIMEFSMWY MHSDPFINRF
FKYLLMFLIT MMILVTANNL FQLFIGWEGV GIMSFLLIGW WHGRTDANTA ALQAVLYNRI
GDVGFIMAMA WFLINLNTWE LQQIFISHHN NLNVPLMGLL LAATGKSAQF GLHPWLPSAM
EGPTPVSALL HSSTMVVAGV FLLIRFHPLM EHNTMMQTTT LCLGAITTLF TAICALTQND
IKKIIAFSTS SQLGLMIVTI GINQPHLAFL HICTHAFFKA MLFLCSGSII HNLNDEQDIR
KMGGLYKVLP FTTTSLIVGS LALTGMPFLT GFYSKDLIIE TANTSYTNAW ALLLTLVATS
MTAAYSTRIM FFALLDQPRF NPMITINENS PLLINPIKRL LLGSIFAGYL ISYNITPTST
PQMTMPHYLK LMALTVTLLG FILALELNLT SQSLKLKHPS NLFKFSNLLG YFPTIIHRYM
PMVNLSASQK LASTLLDAIW LENALPKSIS YFHMKSSVTI SNQKGLIKLY FLSFIITLIL
ALMMINSHE
