NU5M_HORSE
ID NU5M_HORSE Reviewed; 604 AA.
AC P48656;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 5;
DE EC=7.1.1.2 {ECO:0000250|UniProtKB:P03915};
DE AltName: Full=NADH dehydrogenase subunit 5;
GN Name=MT-ND5; Synonyms=MTND5, NADH5, ND5;
OS Equus caballus (Horse).
OG Mitochondrion.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000312|Proteomes:UP000002281};
RX PubMed=7958969; DOI=10.1016/0378-1119(94)90713-7;
RA Xu X., Arnason U.;
RT "The complete mitochondrial DNA sequence of the horse, Equus caballus:
RT extensive heteroplasmy of the control region.";
RL Gene 148:357-362(1994).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC NADH through the respiratory chain, using ubiquinone as an electron
CC acceptor. Essential for the catalytic activity and assembly of complex
CC I. {ECO:0000250|UniProtKB:P03915}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC Evidence={ECO:0000250|UniProtKB:P03915};
CC -!- SUBUNIT: Core subunit of respiratory chain NADH dehydrogenase (Complex
CC I) which is composed of 45 different subunits.
CC {ECO:0000250|UniProtKB:P03920}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:P03920}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the complex I subunit 5 family. {ECO:0000305}.
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DR EMBL; X79547; CAA56089.1; -; Genomic_DNA.
DR PIR; T11867; T11867.
DR RefSeq; NP_007170.1; NC_001640.1.
DR AlphaFoldDB; P48656; -.
DR SMR; P48656; -.
DR STRING; 9796.ENSECAP00000023103; -.
DR PaxDb; P48656; -.
DR Ensembl; ENSECAT00000029862; ENSECAP00000023103; ENSECAG00000027694.
DR GeneID; 807853; -.
DR KEGG; ecb:807853; -.
DR CTD; 4540; -.
DR VGNC; VGNC:59020; MT-ND5.
DR GeneTree; ENSGT00730000111303; -.
DR HOGENOM; CLU_007100_6_0_1; -.
DR InParanoid; P48656; -.
DR OMA; GVGIMSF; -.
DR OrthoDB; 526738at2759; -.
DR Proteomes; UP000002281; Mitochondrion.
DR Bgee; ENSECAG00000027694; Expressed in adult mammalian kidney and 23 other tissues.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; IBA:GO_Central.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; ISS:UniProtKB.
DR GO; GO:0003954; F:NADH dehydrogenase activity; IBA:GO_Central.
DR GO; GO:0015990; P:electron transport coupled proton transport; IBA:GO_Central.
DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; ISS:UniProtKB.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR InterPro; IPR010934; NADH_DH_su5_C.
DR InterPro; IPR018393; NADHpl_OxRdtase_5_subgr.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR003945; NU5C-like.
DR InterPro; IPR001516; Proton_antipo_N.
DR PANTHER; PTHR42829; PTHR42829; 1.
DR Pfam; PF06455; NADH5_C; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR Pfam; PF00662; Proton_antipo_N; 1.
DR TIGRFAMs; TIGR01974; NDH_I_L; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Reference proteome; Respiratory chain; Translocase; Transmembrane;
KW Transmembrane helix; Transport; Ubiquinone.
FT CHAIN 1..604
FT /note="NADH-ubiquinone oxidoreductase chain 5"
FT /id="PRO_0000118100"
FT TRANSMEM 2..22
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 41..61
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 85..105
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 115..135
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..158
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 169..189
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 209..231
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 239..259
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 271..291
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 299..318
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 323..345
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 364..384
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 411..431
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 455..475
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 486..506
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 582..602
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 604 AA; 68057 MW; 5E794F1730235C10 CRC64;
MFSSLMLVSL LVLTLPIMLS IFNTYKNSTF PHHVKNTISY AFITSLIPTM MFIHSGQETI
ISNWHWMTMQ TLKLSLSFKL DYFSMIFVPV ALFVTWSIME FSLWYMHSDP YITRFFKYLL
TFLITMMILV TANNLFQLFI GWEGVGIMSF LLIGWWYGRT DANTAALQAI LYNRIGDIGF
IMAMAWFLFN TNTWDLQQIF MLDPNLTNLP LLGLLLAATG KSAQFGLHPW LPSAMEGPTP
VSALLHSSTM VVAGVFLLIR FHPLMENNKT IQSLTLCLGA ITTLFTAICA LTQNDIKKII
AFSTSSQLGL MIVTIGINQP YLAFLHICTH AFFKAMLFMC SGSIIHSLND EQDIRKMGGL
FNAMPFTTTS LIIGSLALTG IPFLTGFYSK DLIIETANTS YTNAWALLMT LIATSLTAVY
STRIIFFALL GQPRFLPLTS INENNPFLIN SIKRLLIGSI FAGFFISNNI YPTTVPEMTM
PTYMKLTALA VTILGFTLAL ELSLMTHNLK LEHSTNVFKF SNLLGYYPTI MHRLPPLANL
SMSQKSASLL LDSIWLENIL PKSISQFQMK TSILISTQKG QIKLYFLSFL ITLTLSMLLF
NLHE
