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NU5M_HYLLA
ID   NU5M_HYLLA              Reviewed;         603 AA.
AC   P03919;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 2.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 5;
DE            EC=7.1.1.2 {ECO:0000250|UniProtKB:P03915};
DE   AltName: Full=NADH dehydrogenase subunit 5;
GN   Name=MT-ND5; Synonyms=MTND5, NADH5, ND5;
OS   Hylobates lar (Common gibbon) (White-handed gibbon).
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC   Hylobates.
OX   NCBI_TaxID=9580;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Isolate Ester;
RA   Arnason U., Gullberg A., Xu X.;
RT   "A complete mitochondrial DNA molecule of the white-handed gibbon,
RT   Hylobates lar, and comparison among individual mitochondrial genes of all
RT   hominoid genera.";
RL   Hereditas 124:185-189(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-79.
RX   PubMed=6284948; DOI=10.1007/bf01734101;
RA   Brown W.M., Prager E.M., Wang A., Wilson A.C.;
RT   "Mitochondrial DNA sequences of primates: tempo and mode of evolution.";
RL   J. Mol. Evol. 18:225-239(1982).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC       NADH through the respiratory chain, using ubiquinone as an electron
CC       acceptor. Essential for the catalytic activity and assembly of complex
CC       I. {ECO:0000250|UniProtKB:P03915}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC         Evidence={ECO:0000250|UniProtKB:P03915};
CC   -!- SUBUNIT: Core subunit of respiratory chain NADH dehydrogenase (Complex
CC       I) which is composed of 45 different subunits.
CC       {ECO:0000250|UniProtKB:P03920}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:P03920}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 5 family. {ECO:0000305}.
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DR   EMBL; X99256; CAA67638.1; -; Genomic_DNA.
DR   EMBL; V00659; CAA24025.1; -; Genomic_DNA.
DR   PIR; T11843; T11843.
DR   RefSeq; NP_007832.1; NC_002082.1.
DR   AlphaFoldDB; P03919; -.
DR   SMR; P03919; -.
DR   GeneID; 808465; -.
DR   CTD; 4540; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR   GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; ISS:UniProtKB.
DR   GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; ISS:UniProtKB.
DR   GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR   InterPro; IPR010934; NADH_DH_su5_C.
DR   InterPro; IPR018393; NADHpl_OxRdtase_5_subgr.
DR   InterPro; IPR001750; ND/Mrp_mem.
DR   InterPro; IPR003945; NU5C-like.
DR   InterPro; IPR001516; Proton_antipo_N.
DR   PANTHER; PTHR42829; PTHR42829; 1.
DR   Pfam; PF06455; NADH5_C; 1.
DR   Pfam; PF00361; Proton_antipo_M; 1.
DR   Pfam; PF00662; Proton_antipo_N; 1.
DR   TIGRFAMs; TIGR01974; NDH_I_L; 1.
PE   3: Inferred from homology;
KW   Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW   Transport; Ubiquinone.
FT   CHAIN           1..603
FT                   /note="NADH-ubiquinone oxidoreductase chain 5"
FT                   /id="PRO_0000118102"
FT   TRANSMEM        4..24
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        36..56
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        87..107
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        114..134
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        137..157
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        171..191
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        200..220
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        241..261
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        272..292
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        301..320
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        325..347
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        366..386
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        407..429
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        457..477
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        482..502
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        583..603
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   603 AA;  67361 MW;  3BFF99C6EA7BCE70 CRC64;
     MAMYTTMAIL TLTSLIPPIT ATLINPNKKN LYPHYVKMTI ASTFMISLFP TMMFMCTDQE
     TIISNWHWTA TQTLELSLSF KLDYFSMMFI PIALFVTWSI MEFSLWYMHS DPNINQFFKY
     LLIFLTTMLI LVTANNLFQL FIGWEGVGIM SFLLIGWWHA REEANTAAIQ AILYNRIGDI
     GFILALAWFL LHTNSWEPQQ MILLNSNPNF LPLAGLLLAA RGKSAQLGLH PWLPSAMEGP
     TPVSALLHSS TMVVAGVFLL IRFHPLTENN QLIQTLTLCL GAITTLFTAI CALTQNDIKK
     IVAFSTSSQL GLMVVTIGIN QPYLAFLHIC THAFFKAMLF MCSGSIIHNL NNEQDIRKMG
     GLFKTLPLTS TSLTIGSLAL TGMPFLTGFY SKDLIIETAN MSYTNAWALS TTLIATSLTS
     AYSTRMILLT LTNRPRFPTL TNINENNPTL LNPIKRLTIG SLLAGFLIIN SIPPTSPSQT
     TIPLYLKLTA LSITLLGFLT AFDLHLLTNK LKMKNPSHTF HFSNMLGFYP NTIHRTIPYA
     SLTMSQNLAS LLLDLAWLEK LMPKTISHHQ ISASVTISSQ KGMIKLYSLS LLIPLSLTLL
     LIM
 
 
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