ID   NU5M_HYPJE              Reviewed;         692 AA.
AC   Q8SHP7;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 5;
DE            EC=7.1.1.2;
GN   Name=nd5;
OS   Hypocrea jecorina (Trichoderma reesei).
OG   Mitochondrion.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Hypocreaceae; Trichoderma.
OX   NCBI_TaxID=51453;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11825887; DOI=10.1074/jbc.m107651200;
RA   Chambergo F.S., Bonaccorsi E.D., Ferreira A.J.S., Ramos A.S.P.,
RA   Ferreira J.R. Jr., Abrahao-Neto J., Farah J.P.S., El-Dorry H.;
RT   "Elucidation of the metabolic fate of glucose in the filamentous fungus
RT   Trichoderma reesei using expressed sequence tag (EST) analysis and cDNA
RT   microarrays.";
RL   J. Biol. Chem. 277:13983-13988(2002).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) that is believed to belong to the
CC       minimal assembly required for catalysis. Complex I functions in the
CC       transfer of electrons from NADH to the respiratory chain. The immediate
CC       electron acceptor for the enzyme is believed to be ubiquinone (By
CC       similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 5 family. {ECO:0000305}.
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DR   EMBL; AF447590; AAL74164.1; -; Genomic_DNA.
DR   RefSeq; NP_570156.1; NC_003388.1.
DR   AlphaFoldDB; Q8SHP7; -.
DR   SMR; Q8SHP7; -.
DR   GeneID; 804634; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR   GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR   InterPro; IPR018393; NADHpl_OxRdtase_5_subgr.
DR   InterPro; IPR001750; ND/Mrp_mem.
DR   InterPro; IPR003945; NU5C-like.
DR   InterPro; IPR001516; Proton_antipo_N.
DR   PANTHER; PTHR42829; PTHR42829; 1.
DR   Pfam; PF00361; Proton_antipo_M; 1.
DR   Pfam; PF00662; Proton_antipo_N; 1.
DR   TIGRFAMs; TIGR01974; NDH_I_L; 1.
PE   3: Inferred from homology;
KW   Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW   Transport; Ubiquinone.
FT   CHAIN           1..692
FT                   /note="NADH-ubiquinone oxidoreductase chain 5"
FT                   /id="PRO_0000118157"
FT   TRANSMEM        5..23
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        30..52
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        81..103
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        112..129
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        133..155
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        168..190
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        200..222
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        243..262
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        272..294
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        301..319
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        329..351
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        364..386
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        409..431
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        452..471
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        511..528
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        535..557
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        615..637
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   692 AA;  77172 MW;  89821FAAFCBA6C81 CRC64;
     MYLSIIILPL LGSIVSGFFG RKVGVTGSRI LGCLSIITTT ILAIISFFEV GFNNNPISIN
     LFKWLDSESF NMVWNFQFDS LTVSMLIPVL VISSLVHFYS IGYMSHDPHS QRFFSYLSLF
     TFMMIILVTG NNYLLMFVGW EGVGVCSYLL VSFWFTRIAA NQSSLSAFLT NRVGDCFLTI
     GMFVILWSLG NLDYSTVFSL APYINENIIT IIGICLLIGA MAKSSQVGLH IWLPMAMEGP
     TPVSALIHAA TMVTAGVYLL IRSSPLIEYS STVLLICLWL GAVTTVFSSL IGLFQQDIKK
     IIAYSTMSQL GMMVIAIGLS SYNVAIFHLI NHAFYKGLLF LGAGAVIHAV VDNQDLRKYG
     GLISFLPLTY TVILIASLSL VAFPFMTGFF SKDFILESAY GQYHFSSINV YFIATIGAVF
     TTLYSVKVIY LTFLANPNGS VNYYKNAHEG DIFLSLPLVI LAIFSIYFGY LTKDIYIGLG
     SGFFIDNSIF IHPMREILID TEFGVPTIFK LLPFFLTIFF SVLSIVYYEY MPKVVVDFNL
     TNLGYYIYGF FNQRFLVEFF YNKYIVNTVL DLGGQTTKIL DKGSVEWIGP YGFGIALVKA
     SKTVSGLGKG VVTDYALYIL IGACFYLSIF TFISIFFDLA NSITLSCVLV LLGVNNYVKL
     NKNDNINENS LTSSFLWSNT KEMSKYTTKI II