NU5M_LATCH
ID NU5M_LATCH Reviewed; 611 AA.
AC O03174;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1997, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 5;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 5;
GN Name=MT-ND5; Synonyms=MTND5, NADH5, ND5;
OS Latimeria chalumnae (Coelacanth).
OG Mitochondrion.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=9215903; DOI=10.1093/genetics/146.3.995;
RA Zardoya R., Meyer A.;
RT "The complete DNA sequence of the mitochondrial genome of a 'living
RT fossil,' the coelacanth (Latimeria chalumnae).";
RL Genetics 146:995-1010(1997).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the complex I subunit 5 family. {ECO:0000305}.
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DR EMBL; U82228; AAC60328.1; -; Genomic_DNA.
DR PIR; C58893; C58893.
DR RefSeq; NP_008339.1; NC_001804.1.
DR AlphaFoldDB; O03174; -.
DR SMR; O03174; -.
DR STRING; 7897.ENSLACP00000021815; -.
DR Ensembl; ENSLACT00000024871; ENSLACP00000021815; ENSLACG00000022087.
DR GeneID; 808093; -.
DR KEGG; lcm:808093; -.
DR CTD; 4540; -.
DR eggNOG; KOG4668; Eukaryota.
DR GeneTree; ENSGT00730000111303; -.
DR HOGENOM; CLU_007100_6_0_1; -.
DR InParanoid; O03174; -.
DR OMA; GVGIMSF; -.
DR OrthoDB; 526738at2759; -.
DR TreeFam; TF342974; -.
DR Proteomes; UP000008672; Mitochondrion.
DR Bgee; ENSLACG00000022087; Expressed in mesonephros and 6 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR InterPro; IPR010934; NADH_DH_su5_C.
DR InterPro; IPR018393; NADHpl_OxRdtase_5_subgr.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR003945; NU5C-like.
DR InterPro; IPR001516; Proton_antipo_N.
DR PANTHER; PTHR42829; PTHR42829; 1.
DR Pfam; PF06455; NADH5_C; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR Pfam; PF00662; Proton_antipo_N; 1.
DR TIGRFAMs; TIGR01974; NDH_I_L; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Reference proteome; Respiratory chain; Translocase; Transmembrane;
KW Transmembrane helix; Transport; Ubiquinone.
FT CHAIN 1..611
FT /note="NADH-ubiquinone oxidoreductase chain 5"
FT /id="PRO_0000118103"
FT TRANSMEM 3..23
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 38..58
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 91..111
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 121..141
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 142..162
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 175..195
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 205..225
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 246..266
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 277..297
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 306..326
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 329..349
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 375..395
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 417..437
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 462..482
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 493..513
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 591..611
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 611 AA; 68753 MW; 07728B84BCA43071 CRC64;
MYTTLIFNST LMTMFTILTA PILTTLNPIK PNKKWTELWV KTAVQLAFFT SLIPLFIYLD
QGIETITTNW QWMNTNTFNI NISFKFDQYS IVFIPIALYV TWSILEFANW YMHQDPKMNQ
FFKYLLLFLI TMMILVTANN MFQLFIGWEG VGIMSFLLIG WWHGRANANT AALQAVIYNR
VGDIGLTLSM VWFAINLNTW EMQQMFIMSY NTDMTIPLLG LTLAAAGKSA QFGLHPWLPA
AMEGPTPVSA LLHSSTMVVA GIFLLIRLHP LMDNNKLILT TCLCLGALTT LFTAACALTQ
NDIKKIIAFS TSSQLGLMMV AIGLNQPQLA FLHICTHAFF KAMLFLCSGS IIHSLNDEQD
IRKMGGLHNM LPTTSSCTMV SSMALTGMPF LAGFFSKDAI IESLNSSHLN AWALTTTLMA
TSFTAVYSLR IIYLVMMNYP RFQSLSPIDE NYTKTRNPIK RLAWGSVIAG MMIFLNILPT
KSQTMTMPTH MKTAAIMVTI LGVLTAMELT KLTSTQLKIT PNVNMHNSSN MLGYFPNIIH
RLLPQTNLYL GQKMATHLTD QTWFEKIGPK GILALQIPTT KMINNSQQGL IKTYLTLFFL
TTVLFTTMTM I
