NU5M_LEMCA
ID NU5M_LEMCA Reviewed; 603 AA.
AC Q34879; Q8LX24;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 29-MAR-2005, sequence version 2.
DT 25-MAY-2022, entry version 76.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 5;
DE EC=7.1.1.2 {ECO:0000250|UniProtKB:P03915};
DE AltName: Full=NADH dehydrogenase subunit 5;
GN Name=MT-ND5; Synonyms=MTND5, NADH5, ND5;
OS Lemur catta (Ring-tailed lemur).
OG Mitochondrion.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC Lemuridae; Lemur.
OX NCBI_TaxID=9447;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=12034869; DOI=10.1073/pnas.102164299;
RA Arnason U., Adegoke J.A., Bodin K., Born E.W., Esa Y.B., Gullberg A.,
RA Nilsson M., Short R.V., Xu X., Janke A.;
RT "Mammalian mitogenomic relationships and the root of the eutherian tree.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:8151-8156(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-79.
RX PubMed=3146681; DOI=10.1093/oxfordjournals.molbev.a040524;
RA Hayasaka K., Gojobori T., Horai S.;
RT "Molecular phylogeny and evolution of primate mitochondrial DNA.";
RL Mol. Biol. Evol. 5:626-644(1988).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC NADH through the respiratory chain, using ubiquinone as an electron
CC acceptor. Essential for the catalytic activity and assembly of complex
CC I. {ECO:0000250|UniProtKB:P03915}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC Evidence={ECO:0000250|UniProtKB:P03915};
CC -!- SUBUNIT: Core subunit of respiratory chain NADH dehydrogenase (Complex
CC I) which is composed of 45 different subunits.
CC {ECO:0000250|UniProtKB:P03920}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:P03920}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the complex I subunit 5 family. {ECO:0000305}.
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DR EMBL; AJ421451; CAD13431.1; -; Genomic_DNA.
DR EMBL; M22657; AAA69752.1; -; Genomic_DNA.
DR PIR; I77320; I77320.
DR RefSeq; NP_659298.1; NC_004025.1.
DR AlphaFoldDB; Q34879; -.
DR SMR; Q34879; -.
DR GeneID; 804956; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; ISS:UniProtKB.
DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; ISS:UniProtKB.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR InterPro; IPR010934; NADH_DH_su5_C.
DR InterPro; IPR018393; NADHpl_OxRdtase_5_subgr.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR003945; NU5C-like.
DR InterPro; IPR001516; Proton_antipo_N.
DR PANTHER; PTHR42829; PTHR42829; 1.
DR Pfam; PF06455; NADH5_C; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR Pfam; PF00662; Proton_antipo_N; 1.
DR TIGRFAMs; TIGR01974; NDH_I_L; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW Transport; Ubiquinone.
FT CHAIN 1..603
FT /note="NADH-ubiquinone oxidoreductase chain 5"
FT /id="PRO_0000118104"
FT TRANSMEM 3..23
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 38..58
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..107
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 117..137
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 171..191
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 211..233
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 241..261
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..293
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 301..320
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 325..347
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 366..386
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 413..433
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 457..477
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 482..502
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 583..603
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 603 AA; 68078 MW; A1C5DED730504806 CRC64;
MNLLSSFTLV TLIILTLPII MNVTNMYKNY PYAPYVKSSI ACAFITSLIP TMLFISSGQE
TIISNWHWMT IQTLKLSISF KLDYFSMLFM PVALFVTWSI MEFSMWYMHS DPNMNQFFKY
LLMFLITMLI LVTANNLFQL FIGWEGVGIM SFLLIGWWYG RTDANTAALQ AILYNRIGDI
GFILAMAWFL MYSNTWEFQQ MFMLNYHPDM IPLIGLLLAA TGKSAQFGLH PWLPSAMEGP
TPVSALLHSS TMVVAGIFLL IRFYPLMENN KTIQTLMLCL GAITTLFTAI CALTQNDIKK
IVAFSTSSQL GLMMVTMGIN QPHLAFLHIC NHAFFKAMLF MCSGSIIHNL NDEQDIRKMG
GLFKSMPFTS SSLMIGSLAL TGMPFLTGFY SKDLIIESVN TSNTNAWALT ITLIATSMTA
IYSIRIIFYA LLGQPRFTTS TPINENNPLL INSIKRLALG SILAGFFLTN NILPMNVPQM
TMPLYLKLTA LMVTITGFAL AMELNLMTNN LKFKLPSDIY KFSNSLGFYP MTMHRLIPSH
NLIMSQNTAS LLLDLIWMEK TMPKNLSQLQ MTSSTAISNQ MGLVKFYFLS FLMSLLFTLL
LII
