ID   NU5M_LOCMI              Reviewed;         572 AA.
AC   Q36428;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 5;
DE            EC=7.1.1.2;
DE   AltName: Full=NADH dehydrogenase subunit 5;
GN   Name=ND5;
OS   Locusta migratoria (Migratory locust).
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Polyneoptera; Orthoptera; Caelifera; Acrididea; Acridomorpha;
OC   Acridoidea; Acrididae; Oedipodinae; Locusta.
OX   NCBI_TaxID=7004;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8587138; DOI=10.1007/bf00173173;
RA   Flook P.K., Rowell C.H.F., Gellissen G.;
RT   "The sequence, organization, and evolution of the Locusta migratoria
RT   mitochondrial genome.";
RL   J. Mol. Evol. 41:928-941(1995).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) that is believed to belong to the
CC       minimal assembly required for catalysis. Complex I functions in the
CC       transfer of electrons from NADH to the respiratory chain. The immediate
CC       electron acceptor for the enzyme is believed to be ubiquinone (By
CC       similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 5 family. {ECO:0000305}.
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DR   EMBL; X80245; CAA56538.1; -; Genomic_DNA.
DR   PIR; T11478; T11478.
DR   RefSeq; NP_007297.1; NC_001712.1.
DR   AlphaFoldDB; Q36428; -.
DR   SMR; Q36428; -.
DR   GeneID; 807957; -.
DR   CTD; 4540; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR   GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR   InterPro; IPR010934; NADH_DH_su5_C.
DR   InterPro; IPR001750; ND/Mrp_mem.
DR   InterPro; IPR003945; NU5C-like.
DR   InterPro; IPR001516; Proton_antipo_N.
DR   PANTHER; PTHR42829; PTHR42829; 1.
DR   Pfam; PF06455; NADH5_C; 1.
DR   Pfam; PF00361; Proton_antipo_M; 1.
DR   Pfam; PF00662; Proton_antipo_N; 1.
PE   3: Inferred from homology;
KW   Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW   Transport; Ubiquinone.
FT   CHAIN           1..572
FT                   /note="NADH-ubiquinone oxidoreductase chain 5"
FT                   /id="PRO_0000118106"
FT   TRANSMEM        6..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        44..64
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        86..106
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        107..127
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        147..167
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        179..201
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        208..230
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        234..254
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        268..288
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        291..311
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        337..357
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        372..394
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        422..442
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        454..474
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        479..499
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        524..544
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        552..572
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   572 AA;  66045 MW;  D846818F0BE88651 CRC64;
     MCSLSFFFLF LFSTLFFILG IYYLMIDYSL FIEWELFSLN SSMVVMTFII DWMSLVFMSF
     VMYISSLVIY YSNDYMHNEK NINRFIMIVL MFILSMAFLI ISPNLISILL GWDGLGLVSY
     CLVIYYQNVK SYNAGMLTAL SNRIGDVAIL ISISWMLNFG SWNYIYYYYF ISDSFEMKII
     TLLIILAAMT KSAQIPFSSW LPAAMAAPTP VSALVHSSTL VTAGVYLLIR FNPMLMVYDF
     GWYILFIGCL TMFMSGLGAN FEFDLKKIIA LSTLSQLGLM MSILSMGYSD LAFFHLLTHA
     LFKALLFMCA GSMIHNLRDS QDIRFMGSII HFMPLTSICF NVSSLCLCGM PFLAGFYSKD
     LILEIVCLSW VNFFIFFLYF FSTGLTASYS FRLFYYSMSG DNNYYSSYSF NDSSYFISFG
     MIGLLIVAVF GGSLLSWLIF PVPYLVVLPW YLKFLTLLTI ILGSYFGYVI SDFVYSYELF
     SLNFLSFVMF TGSMWFMPFL STNYVSYLPL SFGYYSLKSF DSGWGELLGG QGLYSFFVYL
     INYIQSLYDS NFKVYLLTFV FWMFILFVLF FL