NU5M_LOXAF
ID NU5M_LOXAF Reviewed; 606 AA.
AC Q9TA19; Q2I3F1;
DT 10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 25-MAY-2022, entry version 98.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 5;
DE EC=7.1.1.2 {ECO:0000250|UniProtKB:P03915};
DE AltName: Full=NADH dehydrogenase subunit 5;
GN Name=MT-ND5; Synonyms=MTND5, NADH5, ND5;
OS Loxodonta africana (African elephant).
OG Mitochondrion.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC TISSUE=Blood;
RA Hauf J., Waddell P.J., Chalwatzis N., Joger U., Zimmermann F.K.;
RT "The complete mitochondrial genome sequence of the African elephant
RT (Loxodonta africana), phylogenetic relationships of Proboscidea to other
RT mammals and D-loop heteroplasmy.";
RL Zoology 102:184-195(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC TISSUE=Blood;
RX PubMed=16448217; DOI=10.1371/journal.pbio.0040073;
RA Rogaev E.I., Moliaka Y.K., Malyarchuk B.A., Kondrashov F.A., Derenko M.V.,
RA Chumakov I., Grigorenko A.P.;
RT "Complete mitochondrial genome and phylogeny of Pleistocene mammoth
RT Mammuthus primigenius.";
RL PLoS Biol. 4:403-410(2006).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC NADH through the respiratory chain, using ubiquinone as an electron
CC acceptor. Essential for the catalytic activity and assembly of complex
CC I. {ECO:0000250|UniProtKB:P03915}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC Evidence={ECO:0000250|UniProtKB:P03915};
CC -!- SUBUNIT: Core subunit of respiratory chain NADH dehydrogenase (Complex
CC I) which is composed of 45 different subunits.
CC {ECO:0000250|UniProtKB:P03920}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:P03920}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the complex I subunit 5 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=ABC17914.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AJ224821; CAA12148.1; -; Genomic_DNA.
DR EMBL; DQ316069; ABC17914.1; ALT_INIT; Genomic_DNA.
DR PIR; T45560; T45560.
DR RefSeq; NP_009289.1; NC_000934.1.
DR AlphaFoldDB; Q9TA19; -.
DR SMR; Q9TA19; -.
DR STRING; 9785.ENSLAFP00000029501; -.
DR Ensembl; ENSLAFT00000038066; ENSLAFP00000029501; ENSLAFG00000033300.
DR GeneID; 808793; -.
DR KEGG; lav:808793; -.
DR CTD; 4540; -.
DR eggNOG; KOG4668; Eukaryota.
DR GeneTree; ENSGT00730000111303; -.
DR HOGENOM; CLU_007100_6_0_1; -.
DR InParanoid; Q9TA19; -.
DR OMA; GVGIMSF; -.
DR OrthoDB; 526738at2759; -.
DR TreeFam; TF342974; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; IEA:Ensembl.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; ISS:UniProtKB.
DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; ISS:UniProtKB.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR InterPro; IPR010934; NADH_DH_su5_C.
DR InterPro; IPR018393; NADHpl_OxRdtase_5_subgr.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR003945; NU5C-like.
DR InterPro; IPR001516; Proton_antipo_N.
DR PANTHER; PTHR42829; PTHR42829; 1.
DR Pfam; PF06455; NADH5_C; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR Pfam; PF00662; Proton_antipo_N; 1.
DR TIGRFAMs; TIGR01974; NDH_I_L; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Reference proteome; Respiratory chain; Translocase; Transmembrane;
KW Transmembrane helix; Transport; Ubiquinone.
FT CHAIN 1..606
FT /note="NADH-ubiquinone oxidoreductase chain 5"
FT /id="PRO_0000118107"
FT TRANSMEM 3..23
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 38..58
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..107
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 124..144
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 180..200
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 216..236
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 244..264
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 276..296
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 304..323
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 328..350
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 369..389
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 404..424
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 460..480
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 483..503
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 586..606
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 326
FT /note="Q -> H (in Ref. 2; ABC17914)"
FT /evidence="ECO:0000305"
FT CONFLICT 539
FT /note="V -> I (in Ref. 2; ABC17914)"
FT /evidence="ECO:0000305"
FT CONFLICT 543
FT /note="P -> L (in Ref. 2; ABC17914)"
FT /evidence="ECO:0000305"
FT CONFLICT 566
FT /note="P -> L (in Ref. 2; ABC17914)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 606 AA; 68248 MW; 4162299B92E299E0 CRC64;
MKVINLIPTL MLTSLIILTL PIITTLLQNN KTNCFLYITK TAVTYAFAIS LIPTLLFIQS
NQEAYISNWH WMTIHTLKLS MSFKLDFFSL TFMPIALFIT WSIMEFSLWY MHSDPHINRF
FKYLLLFLIT MLILVSANNL LQLFMGWEGV GIMSFLLISW WHGRTDANTA ALQAMLYNRI
GDMGFIMMMA WFTIHLNSWE FQQIFLTNPK NTTLPLLGLL LASAGKSAQF GLHPWLPSAM
EGPTPVSALL HSSTMVMAGV FTLIRFYPLM ENNLTIQTST LCLGAITTLF TAICALTQND
IKKIIALSTS SQLGLMMVTI GINQPQLAFI HMCTHAFFKA MLFLSSGSII HNLNNEQDIR
KMGGLYKTMP ITSTAIIIGS LALTGMPFLT GFYSKDPIIE TANMSYINTW ALLITLIAVS
MTASYSTRII FFALLGQPRY PPLTQVNENN PYLVNPIKRL ILGSIFMGFL ISMNTIPHTT
PQMTMPPHLK FMALAVTLLG FTVATELNNM THNLMFKQPS RMHTFSTMLG YYPTTTHRVL
PYPSLTMSQN LATTIMDSIW LEKMIPKNLT TMQKTAASLV SNQKGLMKLY FLSFLLSITL
GLLIAL
