ID   NU5M_LUMTE              Reviewed;         574 AA.
AC   Q34947;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 5;
DE            EC=7.1.1.2;
DE   AltName: Full=NADH dehydrogenase subunit 5;
GN   Name=ND5;
OS   Lumbricus terrestris (Common earthworm).
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC   Oligochaeta; Crassiclitellata; Lumbricina; Lumbricidae; Lumbricinae;
OC   Lumbricus.
OX   NCBI_TaxID=6398;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8536978; DOI=10.1093/genetics/141.1.305;
RA   Boore J.L., Brown W.M.;
RT   "Complete sequence of the mitochondrial DNA of the annelid worm Lumbricus
RT   terrestris.";
RL   Genetics 141:305-319(1995).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) that is believed to belong to the
CC       minimal assembly required for catalysis. Complex I functions in the
CC       transfer of electrons from NADH to the respiratory chain. The immediate
CC       electron acceptor for the enzyme is believed to be ubiquinone (By
CC       similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 5 family. {ECO:0000305}.
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DR   EMBL; U24570; AAC46871.1; -; Genomic_DNA.
DR   PIR; S58992; S58992.
DR   RefSeq; NP_008245.1; NC_001673.1.
DR   AlphaFoldDB; Q34947; -.
DR   SMR; Q34947; -.
DR   GeneID; 807915; -.
DR   CTD; 4540; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR   GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR   InterPro; IPR010934; NADH_DH_su5_C.
DR   InterPro; IPR001750; ND/Mrp_mem.
DR   InterPro; IPR003945; NU5C-like.
DR   InterPro; IPR001516; Proton_antipo_N.
DR   PANTHER; PTHR42829; PTHR42829; 1.
DR   Pfam; PF06455; NADH5_C; 1.
DR   Pfam; PF00361; Proton_antipo_M; 1.
DR   Pfam; PF00662; Proton_antipo_N; 1.
PE   3: Inferred from homology;
KW   Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW   Transport; Ubiquinone.
FT   CHAIN           1..574
FT                   /note="NADH-ubiquinone oxidoreductase chain 5"
FT                   /id="PRO_0000118108"
FT   TRANSMEM        10..30
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        50..70
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        87..107
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        111..131
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        141..161
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        181..203
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        211..231
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        240..260
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        280..300
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        301..321
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        340..360
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        381..401
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        423..443
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        458..478
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        489..509
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        554..574
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   574 AA;  64325 MW;  3EAF2B919A74162A CRC64;
     MLRMFNTSLV ASKLMWVIFT GMLAPTLYMV HCNSTLLLEW NLFSISSTPM MMTIILDPLG
     LMFSCTVVMI SANILKFSTI YMKEDKFINR FTVLVLLFVL SMNMLIFFPH LIILLLGWDG
     LGIVSFILVI YYQNPKSLAA GMITALTNRI GDVMLLLAIA WTLNQGHWNI LHMWAVDENM
     YQALVIIIAA MTKSAQMPFS SWLPAAMAAP TPVSALVHSS TLVTAGVFLL IRFYNFLSSV
     WWFTTFLLFV AVSTTLMAGL SASSECDMKK IIALSTLSQL GMMMAAMGLG MAHMAFFHMV
     THAMFKALLF VCAGSFIHSH MHSQDLRWMG NLTKQMPTTT SCLIMANLAL CGFPFMSGFY
     SKDMIVEASL YYPHNSLMIN LILFAVGLTA FYSTRFTMCV VLSPNNCGPY MHLEESNSLT
     SPMLLLASMS VISGSALTWI LPLKQEMMMI PLDQKLKTLM LVTLGALMSW FFLTTTNMTK
     TCLYIRHPII NYFSCTMWFL VPLSSQFMMK LPMYVSHNYL KLTDQSWLEL LGGQGINNVS
     SKASNIYLAS LKSTPMNYLM MSSMLLLVAT LVAI