NU5M_LYCSM
ID NU5M_LYCSM Reviewed; 590 AA.
AC O79556;
DT 01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 25-MAY-2022, entry version 79.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 5;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 5;
GN Name=MT-ND5; Synonyms=MTND5, NADH5, ND5;
OS Lycodon semicarinatus (Ryukyu odd-tooth snake) (Eumesodon semicarinatus).
OG Mitochondrion.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Colubridae; Colubrinae; Lycodon.
OX NCBI_TaxID=56549;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC TISSUE=Liver;
RX PubMed=9725849; DOI=10.1093/genetics/150.1.313;
RA Kumazawa Y., Ota H., Nishida M., Ozawa T.;
RT "The complete nucleotide sequence of a snake (Dinodon semicarinatus)
RT mitochondrial genome with two identical control regions.";
RL Genetics 150:313-329(1998).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the complex I subunit 5 family. {ECO:0000305}.
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DR EMBL; AB008539; BAA33032.1; -; Genomic_DNA.
DR PIR; T11098; T11098.
DR RefSeq; NP_008429.1; NC_001945.1.
DR AlphaFoldDB; O79556; -.
DR SMR; O79556; -.
DR GeneID; 808266; -.
DR CTD; 4540; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR InterPro; IPR010934; NADH_DH_su5_C.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR003945; NU5C-like.
DR InterPro; IPR001516; Proton_antipo_N.
DR PANTHER; PTHR42829; PTHR42829; 1.
DR Pfam; PF06455; NADH5_C; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR Pfam; PF00662; Proton_antipo_N; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW Transport; Ubiquinone.
FT CHAIN 1..590
FT /note="NADH-ubiquinone oxidoreductase chain 5"
FT /id="PRO_0000118089"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 31..51
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 77..97
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 104..124
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 130..150
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 167..187
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 190..210
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 230..250
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 261..281
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 314..336
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 355..375
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 398..418
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 439..461
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 466..486
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 568..588
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 590 AA; 66179 MW; B24E0BD829B28DCE CRC64;
MNLITPTIIL TIMLSLMMSI MQPHNNTKNN LMVLFLISLI PINPLLNNNE LTLTLTPLII
SPTENINISI TLDTASLLFT PIALFITWSI TEFSLWYMAT DPNINKFIKY LLTFLITMLV
IITANNMYQL FIGWEGVGIM SFLLIGWWHG RQDANTAALQ AIIYNRIGDI GLIMTTAWMM
TTSSINMQEL MIQHEVVNII PLLGLVAAAT GKSAQFSLHP WLPSAMEGPT PVSALLHSST
MVVAGVFLLI RLHPILHNNK IMLTCCLILG ATTTMFAAAA ATTYFDIKKI IALSTTSQLG
LMMTMIGLNQ PTLAFLHMIT HSFFKAMLFL CSGSYIHNLN NEQDIRMMGG LLKTLPMTSS
FLTIANLSLM GMPFLSGFYS KDTIIETLAN SYTNSWAIMI TMIATILSAC YSTQIMLFTI
MEHPRTHHTT HKETKNITHP LARLMLTSIL MGTMTKMSTL QTTTMVTMPK TIKLMALIST
IIGVLLSKDL THMTHHMKPK KPNKQNMFFN QLAFFNIPHR TITINTLKIS QQTSTELMDL
WTLEVWGPKG LSNTITNTIH LLTQQKNMIK NYMAIFTMTT MTVLLFIMSK
