NU5M_MACFA
ID NU5M_MACFA Reviewed; 79 AA.
AC P50665;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 25-MAY-2022, entry version 61.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 5;
DE EC=7.1.1.2 {ECO:0000250|UniProtKB:P03915};
DE AltName: Full=NADH dehydrogenase subunit 5;
DE Flags: Fragment;
GN Name=MT-ND5; Synonyms=MTND5, NADH5, ND5;
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OG Mitochondrion.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=3146681; DOI=10.1093/oxfordjournals.molbev.a040524;
RA Hayasaka K., Gojobori T., Horai S.;
RT "Molecular phylogeny and evolution of primate mitochondrial DNA.";
RL Mol. Biol. Evol. 5:626-644(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8752012; DOI=10.1093/oxfordjournals.molbev.a025655;
RA Hayasaka K., Fujii K., Horai S.;
RT "Molecular phylogeny of macaques: implications of nucleotide sequences from
RT an 896-base pair region of mitochondrial DNA.";
RL Mol. Biol. Evol. 13:1044-1053(1996).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC NADH through the respiratory chain, using ubiquinone as an electron
CC acceptor. Essential for the catalytic activity and assembly of complex
CC I. {ECO:0000250|UniProtKB:P03915}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC Evidence={ECO:0000250|UniProtKB:P03915};
CC -!- SUBUNIT: Core subunit of respiratory chain NADH dehydrogenase (Complex
CC I) which is composed of 45 different subunits.
CC {ECO:0000250|UniProtKB:P03920}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:P03920}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the complex I subunit 5 family. {ECO:0000305}.
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DR EMBL; M22653; AAA69758.1; -; Genomic_DNA.
DR EMBL; D85275; BAA12762.1; -; Genomic_DNA.
DR PIR; I77326; I77326.
DR AlphaFoldDB; P50665; -.
DR SMR; P50665; -.
DR Proteomes; UP000233100; Mitochondrion.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; ISS:UniProtKB.
DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; ISS:UniProtKB.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Reference proteome; Respiratory chain; Translocase; Transmembrane;
KW Transmembrane helix; Transport; Ubiquinone.
FT CHAIN 1..>79
FT /note="NADH-ubiquinone oxidoreductase chain 5"
FT /id="PRO_0000118109"
FT TRANSMEM 5..27
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 40..57
FT /note="Helical"
FT /evidence="ECO:0000255"
FT NON_TER 79
SQ SEQUENCE 79 AA; 9195 MW; 910316F2FFD25E0D CRC64;
MIMHTPIMMT TLISLTLPIF ATLTNPYKKR SYPDYVKTTV MYAFITSLPS TTLFILSNQE
TTIWSWHWMT TQTLDLTLS
