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NU5M_MAMPR
ID   NU5M_MAMPR              Reviewed;         603 AA.
AC   Q38PR2; Q2I3H7;
DT   18-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 2.
DT   25-MAY-2022, entry version 57.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 5;
DE            EC=7.1.1.2 {ECO:0000250|UniProtKB:P03915};
DE   AltName: Full=NADH dehydrogenase subunit 5;
GN   Name=MT-ND5; Synonyms=MTND5, NADH5, ND5;
OS   Mammuthus primigenius (Siberian woolly mammoth).
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Afrotheria; Proboscidea; Elephantidae; Mammuthus.
OX   NCBI_TaxID=37349;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=16362058; DOI=10.1038/nature04432;
RA   Krause J., Dear P.H., Pollack J.L., Slatkin M., Spriggs H., Barnes I.,
RA   Lister A.M., Ebersberger I., Paeaebo S., Hofreiter M.;
RT   "Multiplex amplification of the mammoth mitochondrial genome and the
RT   evolution of Elephantidae.";
RL   Nature 439:724-727(2006).
RN   [2]
RP   SEQUENCE REVISION TO N-TERMINUS.
RA   Krause J., Dear P.H., Pollack J.L., Slatkin M., Spriggs H., Barnes I.,
RA   Lister A.M., Paabo S., Hofreiter M.;
RL   Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Muscle;
RX   PubMed=16448217; DOI=10.1371/journal.pbio.0040073;
RA   Rogaev E.I., Moliaka Y.K., Malyarchuk B.A., Kondrashov F.A., Derenko M.V.,
RA   Chumakov I., Grigorenko A.P.;
RT   "Complete mitochondrial genome and phylogeny of Pleistocene mammoth
RT   Mammuthus primigenius.";
RL   PLoS Biol. 4:403-410(2006).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC       NADH through the respiratory chain, using ubiquinone as an electron
CC       acceptor. Essential for the catalytic activity and assembly of complex
CC       I. {ECO:0000250|UniProtKB:P03915}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC         Evidence={ECO:0000250|UniProtKB:P03915};
CC   -!- SUBUNIT: Core subunit of respiratory chain NADH dehydrogenase (Complex
CC       I) which is composed of 45 different subunits.
CC       {ECO:0000250|UniProtKB:P03920}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:P03920}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 5 family. {ECO:0000305}.
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DR   EMBL; DQ188829; ABA29794.2; -; Genomic_DNA.
DR   EMBL; DQ316067; ABC17888.1; -; Genomic_DNA.
DR   RefSeq; YP_398764.2; NC_007596.2.
DR   AlphaFoldDB; Q38PR2; -.
DR   SMR; Q38PR2; -.
DR   GeneID; 3773151; -.
DR   CTD; 4540; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR   GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; ISS:UniProtKB.
DR   GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; ISS:UniProtKB.
DR   GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR   InterPro; IPR010934; NADH_DH_su5_C.
DR   InterPro; IPR018393; NADHpl_OxRdtase_5_subgr.
DR   InterPro; IPR001750; ND/Mrp_mem.
DR   InterPro; IPR003945; NU5C-like.
DR   InterPro; IPR001516; Proton_antipo_N.
DR   PANTHER; PTHR42829; PTHR42829; 1.
DR   Pfam; PF06455; NADH5_C; 1.
DR   Pfam; PF00361; Proton_antipo_M; 1.
DR   Pfam; PF00662; Proton_antipo_N; 1.
DR   TIGRFAMs; TIGR01974; NDH_I_L; 1.
PE   3: Inferred from homology;
KW   Electron transport; Extinct organism protein; Membrane; Mitochondrion;
KW   Mitochondrion inner membrane; NAD; Respiratory chain; Translocase;
KW   Transmembrane; Transmembrane helix; Transport; Ubiquinone.
FT   CHAIN           1..603
FT                   /note="NADH-ubiquinone oxidoreductase chain 5"
FT                   /id="PRO_0000232855"
FT   TRANSMEM        4..24
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        35..55
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        84..104
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        121..141
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        177..197
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        213..233
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        241..261
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        273..293
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        301..320
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        325..347
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        366..386
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        413..433
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        457..477
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        480..500
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        583..603
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        273
FT                   /note="V -> I (in Ref. 3; ABC17888)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   603 AA;  67898 MW;  246D5BDDB483B686 CRC64;
     MNPISTLTLA SLIILTLPIT TTLLQNNKTN CFLYITKTAV TYAFVISLIP TLLFVQSNQE
     AYISNWHWMT IHTLKLSLSF KLDFFSLTFM PIALFITWSI MEFSLWYMHS DPHINRFFKY
     LLLFLITMLI LVSANNLLQL FMGWEGVGIM SFLLISWWHG RTDANTAALQ AMLYNRIGDM
     GFIMMMAWFI IHLNSWEFQQ IFLTNPKNTT LPLLGLLLAS TGKSAQFGLH PWLPSAMEGP
     TPVSALLHSS TMVMAGVFTL IRFYPLMENN LTVQTSTLCL GAITTLFTAI CALTQNDIKK
     IIALSTSSQL GLMMVTIGIN QPHLAFTHMC THAFFKAMLF LSSGSIIHNL DNEQDIRKMG
     GLYKTMPITS TAIIIGSLAL TGMPFLTGFY SKDPIIETAN MSYINTWALL VTLIAVSMTA
     SYSTRIIFFA LLGQPRYPTL TRINENNPHL VNPIKRLILG SIFMGFFISM NTIPHTTPQM
     TMPPHLKFMA LAVTLLGFTV ATELNNMTHN LMFKQPSRMY TFSTTLGYYP TTTHRILPYL
     SLTMSQNLAT TIMDSIWLEK MIPKNLTTMQ KTAASLVSNQ KGLMKLYFLS FLLSITLGLL
     IAL
 
 
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