NU5M_MARPO
ID NU5M_MARPO Reviewed; 669 AA.
AC P26849;
DT 01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1994, sequence version 2.
DT 03-AUG-2022, entry version 81.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 5;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 5;
GN Name=ND5; Synonyms=NAD5;
OS Marchantia polymorpha (Liverwort) (Marchantia aquatica).
OG Mitochondrion.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Marchantiophyta;
OC Marchantiopsida; Marchantiidae; Marchantiales; Marchantiaceae; Marchantia.
OX NCBI_TaxID=3197;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1731062; DOI=10.1016/0022-2836(92)90708-r;
RA Oda K., Yamato K., Ohta E., Nakamura Y., Takemura M., Nozato N., Akashi K.,
RA Kanegae T., Ogura Y., Kohchi T., Ohyama K.;
RT "Gene organization deduced from the complete sequence of liverwort
RT Marchantia polymorpha mitochondrial DNA. A primitive form of plant
RT mitochondrial genome.";
RL J. Mol. Biol. 223:1-7(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8483448; DOI=10.1007/bf00279437;
RA Nozato N., Oda K., Yamato K., Ohta E., Takemura M., Akashi K., Fukuzawa H.,
RA Ohyama K.;
RT "Cotranscriptional expression of mitochondrial genes for subunits of NADH
RT dehydrogenase, nad5, nad4, nad2, in Marchantia polymorpha.";
RL Mol. Gen. Genet. 237:343-350(1993).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the complex I subunit 5 family. {ECO:0000305}.
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DR EMBL; M68929; AAC09397.1; -; Genomic_DNA.
DR PIR; S25941; S25941.
DR RefSeq; NP_054400.1; NC_001660.1.
DR AlphaFoldDB; P26849; -.
DR SMR; P26849; -.
DR GeneID; 2702660; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0009536; C:plastid; IEA:UniProt.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR InterPro; IPR010934; NADH_DH_su5_C.
DR InterPro; IPR018393; NADHpl_OxRdtase_5_subgr.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR003945; NU5C-like.
DR InterPro; IPR001516; Proton_antipo_N.
DR PANTHER; PTHR42829; PTHR42829; 1.
DR Pfam; PF06455; NADH5_C; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR Pfam; PF00662; Proton_antipo_N; 1.
DR TIGRFAMs; TIGR01974; NDH_I_L; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW Transport; Ubiquinone.
FT CHAIN 1..669
FT /note="NADH-ubiquinone oxidoreductase chain 5"
FT /id="PRO_0000118112"
FT TRANSMEM 3..23
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 50..70
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 81..100
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 119..139
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 178..198
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 211..231
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 253..273
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 286..306
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 322..342
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 377..397
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 423..443
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 464..484
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 522..542
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 628..648
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 649..669
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 669 AA; 74679 MW; 20574CA7E2C75ECD CRC64;
MYLLIVILPL IGSFAAGFFG RFLGSRGVAV VTTTCVSLSS IFSCIAFYEV ALCASACYIK
IAPWIFSELF DAAWGFLFDS LTVILLLVVT IVSSLVHIYS ISYMSEDPHS PRFFCYLSIF
TFFMLMLVTG DNFIQLFLGW EGVGLASYLL INFWFTRIQA NKAAIKAMLI NRVGDFGLAL
GIMGCFTIFQ TVDFSTIFAC ASAFSEPHHY FLFCNMGFHA ITVICILVFI GAVGKSAQIG
LHTWLPDAME GPTPVSALIH AATMVTAGVF MIARCSPLFE YSPNALIVIT FVGAMTSFFA
ATTGILQNDL KRVIAYSTCS QLGYMIFACG ISNYSVSVFH LMNHACFKAL LFLSAGSVIH
AMSDEQDMRK MGGLASLLPF TYAMMLIGSL SLIGFPFLTG FYSKDVILEL AYTKYTISGN
FAFWLGSVSV FFTSYYSFRL LFLTFLAPTN SFKRDLSRCH DAPILMAIPL ILLAFGSIFV
GYLAKDMMIG LGTNFWANSL FILPKNEILA ESEFATPTII KLIPILFSTL GSFVAYSVNF
VVNPLIFALK TSTFGNRLYC FFNKRWFFDK VFNDFLARSF LRFGYEVSFK ALDKGAIEIL
GPYGISYTIR KMAQQISKIQ SGFVYHYAFV MLLGLTIFIS VIGLWDFISF WVDNRLYFIY
IVSFLFINI
