NU5M_MYTED
ID NU5M_MYTED Reviewed; 568 AA.
AC Q00232; Q68SQ8;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2005, sequence version 2.
DT 03-AUG-2022, entry version 72.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 5;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 5;
GN Name=ND5;
OS Mytilus edulis (Blue mussel).
OG Mitochondrion.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC Autobranchia; Pteriomorphia; Mytilida; Mytiloidea; Mytilidae; Mytilinae;
OC Mytilus.
OX NCBI_TaxID=6550;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND SEQUENCE REVISION TO 442-457.
RX PubMed=15014161; DOI=10.1093/molbev/msh090;
RA Boore J.L., Medina M., Rosenberg L.A.;
RT "Complete sequences of the highly rearranged molluscan mitochondrial
RT genomes of the scaphopod Graptacme eborea and the bivalve Mytilus edulis.";
RL Mol. Biol. Evol. 21:1492-1503(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-457 AND 504-568.
RX PubMed=1386586; DOI=10.1093/genetics/131.2.397;
RA Hoffmann R.J., Boore J.L., Brown W.M.;
RT "A novel mitochondrial genome organization for the blue mussel, Mytilus
RT edulis.";
RL Genetics 131:397-412(1992).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the complex I subunit 5 family. {ECO:0000305}.
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DR EMBL; AY484747; AAT98412.1; -; Genomic_DNA.
DR PIR; S28760; S28743.
DR RefSeq; YP_073346.1; NC_006161.1.
DR AlphaFoldDB; Q00232; -.
DR SMR; Q00232; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR InterPro; IPR010934; NADH_DH_su5_C.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR003945; NU5C-like.
DR InterPro; IPR001516; Proton_antipo_N.
DR PANTHER; PTHR42829; PTHR42829; 1.
DR Pfam; PF06455; NADH5_C; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR Pfam; PF00662; Proton_antipo_N; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW Transport; Ubiquinone.
FT CHAIN 1..568
FT /note="NADH-ubiquinone oxidoreductase chain 5"
FT /id="PRO_0000118116"
FT TRANSMEM 7..27
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 44..64
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 90..110
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 144..164
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 165..185
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 210..232
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 240..260
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 274..294
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 297..317
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 334..354
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 378..398
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 426..446
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 452..472
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 547..567
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 568 AA; 62297 MW; 0883E365A9BE44E6 CRC64;
MQSKGNLGLL MLILTGYLFI FTGSSFGSAY LLEVPVWESN CLSFSFSFLL DNVSMIFVGT
VLVISGSVAT YCKWYMAEEL YYNRFMGLVW LFVLSMVFMI LVPNLLMLLI GWDGLGLTSF
LLVAYYQNNK SLSAAMLTAL TNRIGDVLVL ISISIFLSEG GWLIYSYHPV QMWLNLGFMV
VFAGMTKSAQ MPFCAWLPAA MAAPTPVSSL VHSSTLVTAG VYLVLRSFYI ISSNPYVTQV
LMILSLFTLV LAGSSAVFAF DLKKVIALST LSQLSLMMFS ISILLPSVAF FHLVTHAVFK
ALLFLGAGGV IHSNQSIQDI RGLSSLWQGL PVSMGAMSVA IVSLSGAPFM SGFFSKDLMI
ELSMMDSSVT YGCYLLELLG LIFTSFYSAR IVFSVMLGSN YVNNSTLRIN EHLNMQTPFL
SLYIGAIILG VVLGSKMESF GFVVVLENYE SLSVFFIPFA GLILWRGVIS KLGSSPWSSA
KSLSFFLSMW FMESLTSHPG KVIFFKGSST VAQSLDQGWL ELLGPQGVHA GLGQFSCLNE
IVQKNYFTYQ LVVWGLLVAG GVSLIIFM
