NU5M_MYXGL
ID NU5M_MYXGL Reviewed; 601 AA.
AC Q9G2W8; O63921;
DT 14-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 25-MAY-2022, entry version 75.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 5;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 5;
GN Name=MT-ND5; Synonyms=MTND5, NADH5, ND5;
OS Myxine glutinosa (Atlantic hagfish).
OG Mitochondrion.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Cyclostomata; Myxini;
OC Myxiniformes; Myxinidae; Myxininae; Myxine.
OX NCBI_TaxID=7769;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9541532; DOI=10.1007/pl00006317;
RA Rasmussen A.S., Janke A., Arnason U.;
RT "The mitochondrial DNA molecule of the hagfish (Myxine glutinosa) and
RT vertebrate phylogeny.";
RL J. Mol. Evol. 46:382-388(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11677623; DOI=10.1007/s002390010250;
RA Delarbre C., Rasmussen A.S., Arnason U., Gachelin G.;
RT "The complete mitochondrial genome of the hagfish Myxine glutinosa: unique
RT features of the control region.";
RL J. Mol. Evol. 53:634-641(2001).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the complex I subunit 5 family. {ECO:0000305}.
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DR EMBL; Y15190; CAA75489.1; -; Genomic_DNA.
DR EMBL; AJ404477; CAC20659.1; -; Genomic_DNA.
DR PIR; T13820; T13820.
DR RefSeq; NP_073283.1; NC_002639.1.
DR AlphaFoldDB; Q9G2W8; -.
DR SMR; Q9G2W8; -.
DR GeneID; 802348; -.
DR CTD; 4540; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR InterPro; IPR010934; NADH_DH_su5_C.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR003945; NU5C-like.
DR PANTHER; PTHR42829; PTHR42829; 1.
DR Pfam; PF06455; NADH5_C; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW Transport; Ubiquinone.
FT CHAIN 1..601
FT /note="NADH-ubiquinone oxidoreductase chain 5"
FT /id="PRO_0000118117"
FT TRANSMEM 5..25
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 37..54
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 83..105
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 112..129
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 134..156
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 169..189
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 209..231
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 240..260
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 271..291
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 300..320
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 323..343
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 363..383
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 400..420
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 451..471
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 478..498
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 508..528
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 581..601
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 47
FT /note="L -> F (in Ref. 1; CAA75489)"
FT /evidence="ECO:0000305"
FT CONFLICT 450
FT /note="S -> N (in Ref. 1; CAA75489)"
FT /evidence="ECO:0000305"
FT CONFLICT 578
FT /note="T -> P (in Ref. 1; CAA75489)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 601 AA; 68107 MW; D8FD94B75D7B6F75 CRC64;
MAYNITSLMT NFCLITTILS LTLSFKQNSD NNKITKYMRN AFIISLLPLI IYIDQQMDSS
SSFTSTFNMI SFNLLLGFEA DMYCLTFFSI ALYITWSIMQ FSLWYMHEHN NTLFFKYLTM
FLISMLFFLS ANNLLQLILG WEGMGIMSFL LINWWHNRLE ANSAAMQAII YNRIGDTGLI
IFMIWSALFT NSWNMKQIFI LQNNSMDLWL PLLGIVLAAT GKSAQFMLHP WLLSAMEGPT
PVSALLHSST MVVSGVFLLI RFYPMIKNSQ MIISIILCLG AMTTLFAALC ASSQTDIKKI
IAFSTTSQLG LMTVTIGINQ PQLAFLHMST HAFFKALLFL CSASIIHTIN NEQDIRKMGS
LHLILPFTSS CTLISSLALM GMPYLSGFYS KDIILETLNM SYVNAWALLS TMLATALTSI
YSTRLILLSM AMTPNINTLI FLKKDKNLFS PLIRLTLGSI IFGFIISTFF LPEKQPNFSI
PFNSKILPTI MLILVSSLTL YFMNNHKFSH MPPLFFPSMS GYFPAIFHRL FSYYFLLFPK
KVSSSLLDIL WYETLGPKSI SHNLSSSSSL FNKLSQGTIN NYITIFVITI LSSLLTSALY
F
