ID   NU5M_ONCMY              Reviewed;         612 AA.
AC   P48176;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 5;
DE            EC=7.1.1.2;
DE   AltName: Full=NADH dehydrogenase subunit 5;
GN   Name=MT-ND5; Synonyms=MTND5, NADH5, ND5;
OS   Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Oncorhynchus.
OX   NCBI_TaxID=8022;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Liver;
RX   PubMed=8587139; DOI=10.1007/bf00173174;
RA   Zardoya R., Garrido-Pertierra A., Bautista J.M.;
RT   "The complete nucleotide sequence of the mitochondrial DNA genome of the
RT   rainbow trout, Oncorhynchus mykiss.";
RL   J. Mol. Evol. 41:942-951(1995).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) that is believed to belong to the
CC       minimal assembly required for catalysis. Complex I functions in the
CC       transfer of electrons from NADH to the respiratory chain. The immediate
CC       electron acceptor for the enzyme is believed to be ubiquinone (By
CC       similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 5 family. {ECO:0000305}.
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DR   EMBL; L29771; AAB03357.1; -; Genomic_DNA.
DR   PIR; T09867; T09867.
DR   RefSeq; NP_008300.1; NC_001717.1.
DR   AlphaFoldDB; P48176; -.
DR   SMR; P48176; -.
DR   GeneID; 807977; -.
DR   KEGG; omy:807977; -.
DR   CTD; 4540; -.
DR   OrthoDB; 526738at2759; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR   GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR   InterPro; IPR010934; NADH_DH_su5_C.
DR   InterPro; IPR018393; NADHpl_OxRdtase_5_subgr.
DR   InterPro; IPR001750; ND/Mrp_mem.
DR   InterPro; IPR003945; NU5C-like.
DR   InterPro; IPR001516; Proton_antipo_N.
DR   PANTHER; PTHR42829; PTHR42829; 1.
DR   Pfam; PF06455; NADH5_C; 1.
DR   Pfam; PF00361; Proton_antipo_M; 1.
DR   Pfam; PF00662; Proton_antipo_N; 1.
DR   TIGRFAMs; TIGR01974; NDH_I_L; 1.
PE   3: Inferred from homology;
KW   Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW   Transport; Ubiquinone.
FT   CHAIN           1..612
FT                   /note="NADH-ubiquinone oxidoreductase chain 5"
FT                   /id="PRO_0000118120"
FT   TRANSMEM        4..24
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        48..68
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        92..112
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        127..147
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        176..196
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        215..235
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        247..267
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        279..299
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        307..327
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        330..350
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        376..396
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        410..430
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        463..483
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        494..514
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        591..611
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   612 AA;  67723 MW;  68F885495BD6B5BC CRC64;
     MHPTTLILSS SLLMIFTLLI YPLITTLTPT PQHKNWALTH VKTAIKMAFL VSLLPLFVFL
     DQGTETIVTN WQWMNTTTFD INLSFKFDHY SIIFTPIALY VTWSILEFAS WYMHADPNMN
     RFFKYLLLFL IAMIILVTAN NMFQLFIGWE GVGIMSFLLI GWWHGRADAN TAAMQAVIYN
     RVGDIGLILS MAWFATNLNS WEIQQMFASS KGLDLTLPLM GLILAATGKS AQFGLHPWLP
     SAMEGPTPVS ALLHSSTMVV AGIFLLIRLH PLMEDNQTAL TVCLCLGALT TLFTATCALT
     QNDIKKIVAF STSSQLGLMM VTIGLNQPQL AFLHICTHAF FKAMLFLCSG SIIHSLNDEQ
     DIRKMGGMHN LTPSTSSCLT IGSLALTGTP FLAGFFSKDA IIEALNTSHL NAWALTLTLL
     ATSFTAIYSL RVIFFVSMGH PRFTATAPVN ENNPSVINPI KRLAWGSIIA GLLITSNFLP
     TNTPVMTMPT HLKLAALLVT ISGLLIALEL ASLTNKQFKL HPTLTLHNFS NMLGFFPAII
     HRLTPKLNLT LGQTIASQMV DHTWFEKVGP KELFQLTCLM VTTTSNIQQG MIKTYLTLFF
     LSTTLAVLLT LT